Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q3MQ24

Entry ID Method Resolution Chain Position Source
AF-Q3MQ24-F1 Predicted AlphaFoldDB

27 variants for Q3MQ24

Variant ID(s) Position Change Description Diseaes Association Provenance
rs475181782 26 E>G No EVA
rs456789687 26 E>Q No EVA
rs439468878 27 I>K No EVA
rs451460037 27 I>M No EVA
rs436047263 46 T>M No EVA
rs472623585 51 K>R No EVA
rs442810337 76 P>A No EVA
rs477273205 84 G>A No EVA
rs465269581 84 G>C No EVA
rs481427812 104 F>S No EVA
rs442254030 105 K>N No EVA
rs457065053 106 S>R No EVA
rs475698588 108 P>L No EVA
rs439365361 115 C>* No EVA
rs458279568 116 P>R No EVA
rs479983601 118 K>E No EVA
rs440509065 118 K>M No EVA
rs462147120 127 S>F No EVA
rs451261930 148 K>T No EVA
rs463226686 154 W>R No EVA
rs478483677 157 L>F No EVA
rs445402998 160 D>Y No EVA
rs472274079 174 E>D No EVA
rs467035112 193 T>K No EVA
rs475156036 234 K>N No EVA
rs442108476 234 K>R No EVA
rs434592367 263 N>H No EVA

No associated diseases with Q3MQ24

No regional properties for Q3MQ24

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3MQ24

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Preautophagosomal structure membrane ; Peripheral membrane protein
  • The conjugate detaches from the membrane immediately before or after autophagosome formation is completed
  • Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
Atg12-Atg5-Atg16 complex A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
mitochondria-associated endoplasmic reticulum membrane A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

37 GO annotations of biological process

Name Definition
aggrephagy Selective degradation of protein aggregates by macroautophagy.
antigen processing and presentation of endogenous antigen The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.
autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
autophagy of mitochondrion The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
autophagy of nucleus A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded.
blood vessel remodeling The reorganization or renovation of existing blood vessels.
C-terminal protein lipidation The covalent attachment of a lipid group to the carboxy-terminus of a protein.
cardiac muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cellular response to nitrogen starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
cellular response to nitrosative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
heart contraction The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
mucus secretion The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.
negative regulation of cardiac muscle cell apoptotic process Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
negative regulation of defense response to virus Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
negative regulation of histone H4-K16 acetylation Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation.
negative regulation of innate immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
negative regulation of phagocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
negative regulation of protein ubiquitination Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
negative regulation of reactive oxygen species metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
negative regulation of type I interferon production Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
negative thymic T cell selection The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
otolith development The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure.
positive regulation of mucus secretion Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
positive regulation of viral translation Any process that activates or increases the frequency, rate or extent of viral translation.
protein lipidation involved in autophagosome assembly The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of autophagosome maturation Any process that modulates the frequency, rate or extent of autophagosome maturation.
regulation of cilium assembly Any process that modulates the frequency, rate or extent of cilium assembly.
regulation of cytokine production involved in immune response Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.
regulation of release of sequestered calcium ion into cytosol Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
response to fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
vasodilation An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.
ventricular cardiac muscle cell development The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12380 ATG5 Autophagy protein 5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9H1Y0 ATG5 Autophagy protein 5 Homo sapiens (Human) PR
Q99J83 Atg5 Autophagy protein 5 Mus musculus (Mouse) PR
Q3MQ04 ATG5 Autophagy protein 5 Sus scrofa (Pig) PR
Q3MQ06 Atg5 Autophagy protein 5 Rattus norvegicus (Rat) PR
Q9FFI2 ATG5 Autophagy protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD KVKKHFQKVM
70 80 90 100 110 120
RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI TVHFKSFPEK DLLHCPSKDV
130 140 150 160 170 180
IEAHFMSCVK EADALKHKSQ VINEMQKKDH KQLWMGLQND RFDQFWAINR KLMEYPAEEN
190 200 210 220 230 240
GFRYIPFRIY QTTTERPFIQ KLFRPVSTDG QLHTLGDLLK EVCPSAVAPE DGEKKNQVMI
250 260 270
HGIEPMLETP LQWLSEHLSY PDNFLHISII PQPTD