Q9D880

PR
Gene name
Timm50 (Tim50)
Protein name
Mitochondrial import inner membrane translocase subunit TIM50
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66525
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D880

Entry ID Method Resolution Chain Position Source
AF-Q9D880-F1 Predicted AlphaFoldDB

10 variants for Q9D880

Variant ID(s) Position Change Description Diseaes Association Provenance
rs225273071 45 G>S No EVA
rs3388884030 75 G>V No EVA
rs3388852666 76 A>G No EVA
rs230008888 104 S>N No EVA
rs3388886361 246 V>A No EVA
rs3397672232 284 K>M No EVA
rs3388891489 332 S>P No EVA
rs3397302469 335 Q>P No EVA
rs3397672246 336 G>A No EVA
rs3388876669 350 S>P No EVA

No associated diseases with Q9D880

No regional properties for Q9D880

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9D880

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

5 GO annotations of molecular function

Name Definition
interleukin-2 receptor binding Binding to an interleukin-2 receptor.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

4 GO annotations of biological process

Name Definition
mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
release of cytochrome c from mitochondria The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZB3 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 Bos taurus (Bovine) PR
P58465 Ctdspl CTD small phosphatase-like protein Mus musculus (Mouse) PR
Q8BX07 Ctdsp2 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Mus musculus (Mouse) PR
Q22647 scpl-4 Mitochondrial import inner membrane translocase subunit TIM50 Caenorhabditis elegans PR
Q6NWD4 timm50 Mitochondrial import inner membrane translocase subunit TIM50 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAASAALFSR LRSGLRVGAR GLCTRLAPPP PRTPEQVTEI ANRGGSKAQG PQHQPGSEGP
70 80 90 100 110 120
SYAKKIALWI AGLLGAGGTV SIVYIFGNNP VDENGTKIPD EFDSDPILVQ QLRRTYKYFK
130 140 150 160 170 180
DYRQMIIEPT SPCLLPDPLR EPYYQPPYTL VLELTGVLLH PEWSLATGWR FKKRPGIETL
190 200 210 220 230 240
FQQLAPLYEI VIFTSETGMT AFPLIDSVDP HGFISYRLFR DATRYMEGHH VKDISCLNRD
250 260 270 280 290 300
PARVVVVDCK KEAFRLQPFN GVALRPWDGN SDDRVLLDLS AFLKTIALNQ VEDVRTVLEH
310 320 330 340 350
YALEDDPLEA FKQRQSRLEQ EEQQRLAELS KSNRQGLSFG SLASRLWPRS KQP