P58465

PR
Gene name
Ctdspl (Nif1, Nifl)
Protein name
CTD small phosphatase-like protein
Names
CTDSP-like, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3, NIF-like protein, Nuclear LIM interactor-interacting factor 1, NLI-interacting factor 1, Small C-terminal domain phosphatase 3, SCP3, Small CTD phosphatase 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69274
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58465

Entry ID Method Resolution Chain Position Source
AF-P58465-F1 Predicted AlphaFoldDB

11 variants for P58465

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389074724 54 N>I No EVA
rs3400532630 60 A>S No EVA
rs3389080983 87 V>A No EVA
rs3400821513 143 V>E No EVA
rs3389087345 218 V>E No EVA
rs3389068843 245 M>K No EVA
rs3389068843 245 M>T No EVA
rs3389068860 248 T>M No EVA
rs3389068875 249 E>K No EVA
rs3389056053 268 S>N No EVA
rs3389083666 276 R>K No EVA

No associated diseases with P58465

2 regional properties for P58465

Type Name Position InterPro Accession
domain NIF system FeS cluster assembly, NifU, C-terminal 173 - 239 IPR001075
domain Scaffold protein Nfu/NifU, N-terminal 61 - 148 IPR014824

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
RNA polymerase II CTD heptapeptide repeat phosphatase activity Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of G1/S transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9PTJ6 NFI1 CTD small phosphatase-like protein Gallus gallus (Chicken) PR
O14595 CTDSP2 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Homo sapiens (Human) PR
Q8BX07 Ctdsp2 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Mus musculus (Mouse) PR
Q9D880 Timm50 Mitochondrial import inner membrane translocase subunit TIM50 Mus musculus (Mouse) PR
10 20 30 40 50 60
MDGPAIITQV TNPKEDEARS PVAGEKASQR NISLKKQRGR SILSSFFCCF RDYNVEAPPA
70 80 90 100 110 120
NSPSVLPPLV EENGGLQKGD QRQVIPVPSP PAKYLLPEVT VLDYGKKCVV IDLDETLVHS
130 140 150 160 170 180
SFKPISNADF IVPVEIDGTI HQVYVLKRPH VDEFLQRMGQ LFECVLFTAS LAKYADPVAD
190 200 210 220 230 240
LLDRWGVFRA RLFRESCVFH RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS
250 260 270
WFDDMTDTEL LDLIPFFEGL SREDDVYSML HRLCSR