AiPD: Autoinhibited Protein Database

O14595

Gene name	CTDSP2 (NIF2, OS4, SCP2)
Protein name	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Names	Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10106
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-80 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O14595

Entry ID	Method	Resolution	Chain	Position	Source
2Q5E	X-ray	251 A	A/B/C/D/E/F/G/H	87-271	PDB
AF-O14595-F1	Predicted				AlphaFoldDB

234 variants for O14595

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1592246047 CA385514340	2	E>A		No	ClinGen Ensembl
rs1592246043 CA385514320	3	H>P		No	ClinGen Ensembl
CA237829732 rs74554628	3	H>Q		No	ClinGen gnomAD
CA385514296 rs1399403046	4	G>D		No	ClinGen TOPMed
CA6660685 rs760623765	4	G>S		No	ClinGen ExAC gnomAD
rs778207480 CA385514239	7	I>F		No	ClinGen ExAC TOPMed gnomAD
CA237829715 rs112054763	7	I>T		No	ClinGen TOPMed gnomAD
rs778207480 CA6660683	7	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1439051985 CA385514222	8	T>A		No	ClinGen gnomAD
rs1365203165 CA385514212	8	T>I		No	ClinGen TOPMed gnomAD
rs1232162568 CA385514188	10	A>V		No	ClinGen TOPMed
rs745667327 CA385514183	11	R>P		No	ClinGen ExAC gnomAD
rs745667327 CA6660682 COSM1363457	11	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs796887934 CA237829711	11	R>W		No	ClinGen Ensembl
rs778748540 CA6660681	12	R>K		No	ClinGen ExAC gnomAD
rs778748540 CA237829696	12	R>M		No	ClinGen ExAC gnomAD
CA385514163 rs1420994238	13	E>K		No	ClinGen gnomAD
rs1380452451 CA385514150	13	E>V		No	ClinGen gnomAD
rs1452227615 CA385514113	15	A>S		No	ClinGen gnomAD
rs1269862643 CA385514094	16	L>P		No	ClinGen gnomAD
CA385514083 rs1264306882	17	V>L		No	ClinGen TOPMed
CA385514045 rs1485793872	19	T>P		No	ClinGen TOPMed gnomAD
CA385514039 rs1485793872	19	T>S		No	ClinGen TOPMed gnomAD
rs1240867431 CA385514026	20	K>E		No	ClinGen gnomAD
CA6660654 rs758948371	22	G>D		No	ClinGen ExAC
CA6660653 rs746413808	23	L>V		No	ClinGen ExAC gnomAD
CA385508827 rs1161415481	26	K>E		No	ClinGen TOPMed
TCGA novel	26	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385508824 rs1421892768	26	K>R		No	ClinGen gnomAD
CA385508818 rs1389694042	27	S>A		No	ClinGen TOPMed
rs779294412 CA6660652	27	S>F		No	ClinGen ExAC gnomAD
rs556842470 CA6660650	29	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs141458856 CA6660651	29	P>S		No	ClinGen 1000Genomes ExAC
rs902879976 CA237822309	32	P>S		No	ClinGen TOPMed
rs764230836 COSM3417044 CA6660649	33	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
TCGA novel	34	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6660648 rs756395154	35	R>C		No	ClinGen ExAC gnomAD
CA6660647 rs752762135	35	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs752762135 CA385508771	35	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1425629986 CA385508760	37	I>V		No	ClinGen gnomAD
TCGA novel	43	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385508705 rs1195422665	44	C>R		No	ClinGen gnomAD
CA385508688 rs1479804428	46	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs767635273 CA6660646	46	R>H		No	ClinGen ExAC TOPMed gnomAD
rs767635273 CA385508687	46	R>L		No	ClinGen ExAC TOPMed gnomAD
CA385508685 rs1200318721	47	A>T		No	ClinGen TOPMed gnomAD
rs759439752 CA6660645	47	A>V		No	ClinGen ExAC TOPMed gnomAD
CA385508673 rs1242585123	48	Q>R		No	ClinGen gnomAD
CA385508664 rs1376235665	49	H>L		No	ClinGen TOPMed
CA385508665 rs1376235665	49	H>P		No	ClinGen TOPMed
CA385508666 rs1376235665	49	H>R		No	ClinGen TOPMed
CA6660644 rs368927568	51	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs112213098 CA237822299	52	Q>K		No	ClinGen Ensembl
CA6660642 rs373703024	52	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA6660643 rs373703024	52	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA237822295 rs920674389	54	S>C		No	ClinGen TOPMed gnomAD
rs920674389 CA385508638	54	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA385508637 rs1397705018	54	S>N		No	ClinGen gnomAD
CA6660640 rs375513599	55	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs769313778 CA6660639	57	T>P		No	ClinGen ExAC gnomAD
CA6660638 rs538213727	57	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1161964288 CA385508612	58	E>A		No	ClinGen gnomAD
rs567679377 CA6660636	60	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1181206830 CA385508598	61	A>T		No	ClinGen gnomAD
CA385508593 rs1437999525	61	A>V		No	ClinGen gnomAD
CA385508560 rs1179567892	66	A>T		No	ClinGen gnomAD
rs779305456 CA6660634	68	T>N		No	ClinGen ExAC gnomAD
CA385508538 rs1595189641	69	I>T		No	ClinGen Ensembl
CA6660633 rs771264162	69	I>V		No	ClinGen ExAC gnomAD
rs1358414978 CA385508517	71	K>T		No	ClinGen gnomAD
rs1595188561 CA385508382	72	S>L		No	ClinGen Ensembl
CA385508386 rs1203719482	72	S>P		No	ClinGen TOPMed
CA385508369 rs1595188553	74	L>Q		No	ClinGen Ensembl
CA385508351 rs1595188546	76	Q>K		No	ClinGen Ensembl
CA385508336 rs1378053190	77	C>G		No	ClinGen gnomAD
CA385508337 rs1378053190	77	C>R		No	ClinGen gnomAD
CA6660608 rs371679234	77	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA6660607 rs780227197	78	L>V		No	ClinGen ExAC gnomAD
COSM3936082 CA385508313 rs1264660085	79	Q>*	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs886186516 CA237821650	80	Y>H		No	ClinGen gnomAD
CA385507390 rs1346122762	82	F>S		No	ClinGen gnomAD
CA385507399 rs1220654481	82	F>V		No	ClinGen gnomAD
CA6660604 rs200585191	83	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs367623826 CA6660605	83	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs765716568 CA6660578	85	I>V		No	ClinGen ExAC gnomAD
rs776949485 COSM468731 CA6660576	94	V>M	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA237821357 rs200210037	95	T>A		No	ClinGen 1000Genomes gnomAD
rs201788317 CA237821355	95	T>I		No	ClinGen 1000Genomes
rs75591888 COSM4147354 CA6660575	97	E>K	thyroid [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs74343811 COSM4147353 CA237821344	98	D>N	thyroid [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1025948959 CA237821339	99	Q>E		No	ClinGen gnomAD
rs1025948959 CA237821341	99	Q>K		No	ClinGen gnomAD
rs747149135 CA6660574	101	R>K		No	ClinGen ExAC TOPMed gnomAD
CA237821334 rs747149135	101	R>M		No	ClinGen ExAC TOPMed gnomAD
CA237821332 rs747149135	101	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1595188173 CA385506745	102	I>M		No	ClinGen Ensembl
rs111346934 CA237821320	104	V>M		No	ClinGen Ensembl
CA237821317 rs1056200123	105	V>A		No	ClinGen Ensembl
CA385506683 rs1405443663	105	V>F		No	ClinGen gnomAD
CA6660572 rs76940645	106	I>T		No	ClinGen ExAC TOPMed gnomAD
CA385506607 rs1441212674	107	D>E		No	ClinGen gnomAD
TCGA novel	107	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA237821306 rs796375970	108	L>I		No	ClinGen Ensembl
CA385506556 rs1191005064	109	D>E		No	ClinGen gnomAD
rs779193643 CA6660569	109	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs1595188149 CA385506561	109	D>V		No	ClinGen Ensembl
CA6660568 rs757239164	111	T>I		No	ClinGen ExAC gnomAD
rs757239164 CA237821284	111	T>N		No	ClinGen ExAC gnomAD
rs749282099 CA6660567	114	H>L		No	ClinGen ExAC gnomAD
rs1223017872 CA385506414	115	S>T		No	ClinGen gnomAD
CA237821277 rs113533986	117	F>I		No	ClinGen Ensembl
TCGA novel	118	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs568891111 CA385506143	120	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs568891111 COSM1177735 CA6660545	120	I>V	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA385506106 rs1595187741	121	N>S		No	ClinGen Ensembl
CA385505984 rs1595187734	125	F>C		No	ClinGen Ensembl
rs1595187731 CA385505970	126	I>L		No	ClinGen Ensembl
CA385505968 TCGA novel rs1595187731	126	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA6660544 rs769684225	128	P>S		No	ClinGen ExAC gnomAD
rs769684225 CA385505914	128	P>T		No	ClinGen ExAC gnomAD
rs1565844419 CA385505898	129	I>L		No	ClinGen Ensembl
rs1565844419 CA385505894	129	I>V		No	ClinGen Ensembl
CA385505866 rs1595187716	130	E>K		No	ClinGen Ensembl
rs1595187707 CA385505836	131	I>F		No	ClinGen Ensembl
rs1595187707 CA385505845	131	I>L		No	ClinGen Ensembl
rs747959366 CA385505819	131	I>M		No	ClinGen ExAC TOPMed gnomAD
CA6660542 rs780894928	132	E>D		No	ClinGen ExAC gnomAD
rs930251925 CA237821061	132	E>K		No	ClinGen gnomAD
rs376623825 CA6660541	133	G>E		No	ClinGen ESP ExAC
CA385505743 rs1177629887	134	T>I		No	ClinGen gnomAD
rs1477745119 CA385505706	136	H>Q		No	ClinGen gnomAD
CA6660469 rs764200649	138	V>G		No	ClinGen ExAC gnomAD
rs1441506759 CA385504674	139	Y>C		No	ClinGen gnomAD
rs113443562 CA237820206	142	K>M		No	ClinGen Ensembl
rs767288967 CA6660466	145	Y>*		No	ClinGen ExAC gnomAD
rs113598599 CA237820191	146	V>M		No	ClinGen Ensembl
CA6660464 rs774272222	148	E>D		No	ClinGen ExAC TOPMed gnomAD
CA385504462 rs1322349412	152	R>C		No	ClinGen TOPMed
CA385504457 COSM1202573 rs1270875191	152	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1270875191 CA385504449	152	R>L		No	ClinGen TOPMed gnomAD
CA385504446 rs1338941692	153	M>L		No	ClinGen TOPMed gnomAD
CA385504444 rs1338941692	153	M>V		No	ClinGen TOPMed gnomAD
CA6660461 rs772806247	155	E>D		No	ClinGen ExAC TOPMed gnomAD
rs762703799 CA6660462	155	E>Q		No	ClinGen ExAC gnomAD
rs769447012 CA6660460	158	E>K		No	ClinGen ExAC gnomAD
rs375402815 CA237820164	159	C>Y		No	ClinGen Ensembl
CA385504019 rs1595185768	171	D>A		No	ClinGen Ensembl
rs761403823 CA385504026	171	D>H		No	ClinGen ExAC TOPMed gnomAD
rs761403823 CA6660440	171	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1595185756 CA385503989	173	V>M		No	ClinGen Ensembl
CA385503964 rs1354850326	175	D>H		No	ClinGen TOPMed
CA6660437 rs376232288	179	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1363453 rs772434435 CA6660438	179	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1298658118 CA385503865	180	C>F		No	ClinGen gnomAD
rs1595185710 CA385503812	182	V>G		No	ClinGen Ensembl
CA6660435 rs373350059	184	R>Q		No	ClinGen ESP ExAC
CA6660436 rs779108955	184	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	185	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1424840470 CA385503769	185	A>T		No	ClinGen gnomAD
rs762714721 CA237820079	186	R>C		No	ClinGen Ensembl
rs1161842983 CA385503681	189	R>C		No	ClinGen TOPMed gnomAD
rs1029081352 CA237820078	192	C>R		No	ClinGen Ensembl
CA6660432 rs563483951	192	C>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA237820063 rs904567774	193	V>L		No	ClinGen gnomAD
CA385503562 COSM1238616 rs904567774	193	V>M	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1049782028 CA237820056	195	H>Y		No	ClinGen TOPMed
CA6660429 rs754828681	196	Q>H		No	ClinGen ExAC gnomAD
rs781385318 CA6660430	196	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA237820042 rs369938855	200	V>I		No	ClinGen ESP TOPMed gnomAD
rs113792624 CA237820038	201	K>N		No	ClinGen Ensembl
TCGA novel	201	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385503331 rs1595185625	202	D>N		No	ClinGen Ensembl
rs796106620 CA237820021	203	L>I		No	ClinGen Ensembl
CA237820022 rs796106620	203	L>V		No	ClinGen Ensembl
rs758269345 CA6660426	205	R>C		No	ClinGen ExAC gnomAD
CA237820011 rs796989809	205	R>H		No	ClinGen gnomAD
CA385503152 rs1218267542	209	D>N		No	ClinGen gnomAD
CA385502946 rs1218523648	215	I>V		No	ClinGen gnomAD
rs868709875 CA385502819	219	S>*		No	ClinGen gnomAD
rs868709875 CA237819981	219	S>L		No	ClinGen gnomAD
TCGA novel	219	S>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6660421 rs763692586	221	A>T		No	ClinGen ExAC TOPMed gnomAD
CA385502766 rs1401716612	222	S>A		No	ClinGen TOPMed
rs12822897 CA385502717	223	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	223	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs77410204 CA385502697	224	I>L		No	ClinGen Ensembl
rs77410204 CA237819975	224	I>V		No	ClinGen Ensembl
rs774936151 CA6660419	225	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1477521980 CA385502611	226	H>Y		No	ClinGen gnomAD
CA237819962 rs796175724	227	P>T		No	ClinGen Ensembl
CA237819959 rs932834632	228	E>K		No	ClinGen TOPMed gnomAD
CA6660390 rs780330143	231	V>M		No	ClinGen ExAC gnomAD
TCGA novel	235	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745830190 CA6660388	235	S>P		No	ClinGen ExAC gnomAD
CA385502102 rs1446623816	237	F>L		No	ClinGen gnomAD
CA385502099 rs1430900253	238	D>N		No	ClinGen TOPMed
TCGA novel	239	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6660386 rs757131070	239	D>N		No	ClinGen ExAC gnomAD
TCGA novel	240	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595185266 CA385502051	240	M>I		No	ClinGen Ensembl
rs753366533 CA6660385	240	M>L		No	ClinGen ExAC TOPMed gnomAD
CA385502040 rs1595185264	241	A>P		No	ClinGen Ensembl
rs755782534 CA6660383	246	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA385501959 rs1595185247	247	N>H		No	ClinGen Ensembl
rs370807961 CA385501908	250	P>S		No	ClinGen ESP TOPMed gnomAD
rs370807961 CA237819783	250	P>T		No	ClinGen ESP TOPMed gnomAD
CA237819775 rs375864907	251	I>T		No	ClinGen ESP TOPMed
CA6660381 rs199880488	251	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs200753070 CA385501866	254	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763413608 CA6660380	254	E>G		No	ClinGen ExAC gnomAD
CA237819770 rs796243823	255	L>M		No	ClinGen Ensembl
CA6660378 rs765514458	256	S>C		No	ClinGen ExAC TOPMed gnomAD
CA385501853 CA6660376 rs181892334	257	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385501843 rs1316086382	258	A>V		No	ClinGen gnomAD
TCGA novel	259	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1277304878 CA385501841	259	E>Q		No	ClinGen TOPMed
rs797007497 CA237819765	260	D>G		No	ClinGen Ensembl
rs797007497 CA237819761	260	D>V		No	ClinGen Ensembl
CA385501818 rs1050127790	261	V>F		No	ClinGen TOPMed gnomAD
CA237819752 rs1050127790	261	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1050127790 CA385501820	261	V>L		No	ClinGen TOPMed gnomAD
rs1595185156 CA385501798	262	Y>C		No	ClinGen Ensembl
CA385501787 rs1595185145	263	T>P		No	ClinGen Ensembl
CA6660373 rs775671388	263	T>S		No	ClinGen ExAC TOPMed gnomAD
CA6660372 rs772302721	264	S>T		No	ClinGen ExAC gnomAD
CA385501750 rs1270679448	265	L>V		No	ClinGen TOPMed
CA385501733 rs1301400288	266	G>E		No	ClinGen gnomAD
rs1490408042 CA385501735	266	G>W		No	ClinGen TOPMed
rs796238448 CA237819738	268	L>Q		No	ClinGen Ensembl
rs1184178569 CA385501676	269	R>P		No	ClinGen TOPMed gnomAD
rs1184178569 CA385501679	269	R>Q		No	ClinGen TOPMed gnomAD
rs745742336 CA6660371	269	R>W		No	ClinGen ExAC gnomAD
rs1595185102 CA385501656	270	A>G		No	ClinGen Ensembl
rs779001515 CA6660370	272	P>Y		No	ClinGen ExAC gnomAD

No associated diseases with O14595

2 regional properties for O14595

Type	Name	Position	InterPro Accession
domain	FCP1 homology domain	97 - 261	IPR004274
domain	Dullard phosphatase domain, eukaryotic	102 - 263	IPR011948

Functions

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
myosin phosphatase activity	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
RNA polymerase II CTD heptapeptide repeat phosphatase activity	Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate.

3 GO annotations of biological process

Name	Definition
negative regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
negative regulation of protein phosphorylation	Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9PTJ6	NFI1	CTD small phosphatase-like protein	Gallus gallus (Chicken)	PR
P58465	Ctdspl	CTD small phosphatase-like protein	Mus musculus (Mouse)	PR
Q8BX07	Ctdsp2	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEHGSIITQA	RREDALVLTK	QGLVSKSSPK	KPRGRNIFKA	LFCCFRAQHV	GQSSSSTELA
70	80	90	100	110	120
AYKEEANTIA	KSDLLQCLQY	QFYQIPGTCL	LPEVTEEDQG	RICVVIDLDE	TLVHSSFKPI
130	140	150	160	170	180
NNADFIVPIE	IEGTTHQVYV	LKRPYVDEFL	RRMGELFECV	LFTASLAKYA	DPVTDLLDRC
190	200	210	220	230	240
GVFRARLFRE	SCVFHQGCYV	KDLSRLGRDL	RKTLILDNSP	ASYIFHPENA	VPVQSWFDDM
250	260	270
ADTELLNLIP	IFEELSGAED	VYTSLGQLRA	P