Q8BX07

PR
Gene name
Ctdsp2
Protein name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Names
Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:52468
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BX07

Entry ID Method Resolution Chain Position Source
AF-Q8BX07-F1 Predicted AlphaFoldDB

13 variants for Q8BX07

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389126410 52 Q>* No EVA
rs3389107472 64 E>K No EVA
rs3389131953 101 I>T No EVA
rs3389126441 153 G>R No EVA
rs3389122917 187 F>L No EVA
rs3389140828 190 A>D No EVA
rs48730329 202 L>F No EVA
rs3389071029 206 G>* No EVA
rs3389131924 214 I>T No EVA
rs3389095036 235 W>C No EVA
rs3389118589 238 D>N No EVA
rs3389131907 251 F>S No EVA
rs3389139882 254 L>V No EVA

No associated diseases with Q8BX07

2 regional properties for Q8BX07

Type Name Position InterPro Accession
domain NIF system FeS cluster assembly, NifU, C-terminal 173 - 239 IPR001075
domain Scaffold protein Nfu/NifU, N-terminal 59 - 146 IPR014824

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
RNA polymerase II CTD heptapeptide repeat phosphatase activity Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate.

3 GO annotations of biological process

Name Definition
negative regulation of G1/S transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9PTJ6 NFI1 CTD small phosphatase-like protein Gallus gallus (Chicken) PR
O14595 CTDSP2 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Homo sapiens (Human) PR
P58465 Ctdspl CTD small phosphatase-like protein Mus musculus (Mouse) PR
Q9D880 Timm50 Mitochondrial import inner membrane translocase subunit TIM50 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRSIFKA LLCCFHTQHV VQSSSSTELT
70 80 90 100 110 120
HKEEANTIAK SDLLQCLQYQ FYQIPGTCLL PEVTEQDQGR ICVVIDLDET LVHSSFKPIN
130 140 150 160 170 180
NADFIVPVEI EGTTHQVYVL KRPYVDEFLR RMGELFECVL FTASLAKYAD PVTDLLDRCG
190 200 210 220 230 240
VFRARLFREA CVFHQGCYVK DLSRLGRDLR KTVILDNSPA SYIFHPENAV PVQSWFDDMA
250 260
DTELLNLIPV FEELSGTDDV YTSLGQLRAP