Q6NWD4

PR
Gene name
timm50 (tim50, zgc:66357)
Protein name
Mitochondrial import inner membrane translocase subunit TIM50
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393638
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NWD4

Entry ID Method Resolution Chain Position Source
AF-Q6NWD4-F1 Predicted AlphaFoldDB

No variants for Q6NWD4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NWD4

No associated diseases with Q6NWD4

No regional properties for Q6NWD4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6NWD4

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

2 GO annotations of molecular function

Name Definition
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

4 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZB3 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 Bos taurus (Bovine) PR
Q9D880 Timm50 Mitochondrial import inner membrane translocase subunit TIM50 Mus musculus (Mouse) PR
Q22647 scpl-4 Mitochondrial import inner membrane translocase subunit TIM50 Caenorhabditis elegans PR
10 20 30 40 50 60
MSAVSVYPMC VRASRGLLRL RQGARCSTAP PLLDVVRPLS ADTSSSSATG GLAQAILQER
70 80 90 100 110 120
LQQQQKSQEQ PPPEGEDSGH KQDEQGEDKK QKENTAYAKK MVLRLAGIMG LGGTVGIVYI
130 140 150 160 170 180
FGSNSVDEQG NKIPDEFDND VPVIQQLRRT FKYFKDYRQM IIEPTSPKLL PDPLREPYYQ
190 200 210 220 230 240
PPYTLVLELT DVLLHPEWSL ATGWRFKKRP GIDYLFQQLA PLYEIVIFTS ETGMTAYPLI
250 260 270 280 290 300
DSIDPQGFVM YRLFRDATRY MEGHHVKDVS CLNRDTSKVI VVDCKREAFG LQPFNGLALC
310 320 330 340 350 360
KWDGNSEDRT LYDLAAFLKT IATSGVEDVR SVLENYAHEE DPIEAFKRRQ AQLAREEEQR
370 380
ISEMAQQKKQ GFSLGTIAGR FWSRKQQ