Q22647

PR
Gene name
scpl-4 (tim-50, T21C9.12)
Protein name
Mitochondrial import inner membrane translocase subunit TIM50
Names
Small C-terminal domain Phosphatase protein 4
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T21C9.12
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q22647

Entry ID Method Resolution Chain Position Source
AF-Q22647-F1 Predicted AlphaFoldDB

No variants for Q22647

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q22647

No associated diseases with Q22647

No regional properties for Q22647

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q22647

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZB3 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 Bos taurus (Bovine) PR
Q9D880 Timm50 Mitochondrial import inner membrane translocase subunit TIM50 Mus musculus (Mouse) PR
Q6NWD4 timm50 Mitochondrial import inner membrane translocase subunit TIM50 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSLSKLTQTC FSRHQAKTFI RLYSSDFKSL LGPPAVANPY ADNGRTRFAP IVPINHGNVF
70 80 90 100 110 120
ASIKLPINET QEAIAFKSEV EEAPKVEKLE VESPKIEAEK VLSSPPPAPA PTSSAIDELN
130 140 150 160 170 180
SLKDSLEKLE SAASKSSSSS GGSSDNSDPG NAEEIEARRK RMERNTRIGA YVLFGGSIIG
190 200 210 220 230 240
FISFCFYYGR AQRDEFGNVI SDEFSGSFLA PFYRIANSFK LWRDYVVEPA REQLLPDPLP
250 260 270 280 290 300
APYLQPKYTI VIELKNILVH PEWTYKTGYR FLKRPALDYF LDVIGYPNFE VVIYSSESMM
310 320 330 340 350 360
TAAPVVDSFD PKQRIMYKLF RDCTKYMNGH HVKDLSKLNR DLSKVIYIDF DAKSGQLNPE
370 380 390 400 410 420
NMLRVPEWKG NMDDTSLVDL AELLKTIHLS DAEDVRPMLQ YYSQYDDPAK EFRRRAVYLS
430 440 450
QQEEQKKQQP DDSSMLKRYS GRLFGSRRHV NA