AiPD: Autoinhibited Protein Database

Gene name	Elp3
Protein name	Elongator complex protein 3
Names	tRNA uridine(34) acetyltransferase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74195
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-78 (Predicted disordered autoinhibitory region) PR

1-78 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8AVG	EM	401 A	C	1-547	PDB
AF-Q9CZX0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389340446	112	C>S	No	EVA
rs3389309811	115	G>*	No	EVA
rs3389320178	124	T>I	No	EVA
rs3389339217	127	Y>C	No	EVA
rs3389261369	143	D>G	No	EVA
rs3389261441	160	H>D	No	EVA
rs3389338010	160	H>Q	No	EVA
rs3389261437	161	S>*	No	EVA
rs3389333819	163	D>E	No	EVA
rs3389292129	164	K>M	No	EVA
rs3389332597	165	V>L	No	EVA
rs3389332597	165	V>M	No	EVA
rs3389340481	220	I>F	No	EVA
rs3389344470	224	P>H	No	EVA
rs3389336267	260	R>W	No	EVA
rs3405296991	345	L>R	No	EVA
rs3405207944	365	V>G	No	EVA
rs3389339246	398	C>S	No	EVA
rs31111258	408	I>S	No	EVA
rs3389338064	421	E>V	No	EVA
rs3389292124	439	Y>*	No	EVA
rs46209830	466	G>V	No	EVA
rs3389348828	476	H>Y	No	EVA
rs3389292169	490	T>S	No	EVA
rs3389339193	506	E>D	No	EVA
rs3389333779	522	S>T	No	EVA
rs3389344509	544	K>M	No	EVA
rs3389353440	547	K>*	No	EVA

Type	Name	Position	InterPro Accession
domain	GNAT domain	396 - 547	IPR000182
domain	Elp3/MiaA/NifB-like, radical SAM core domain	89 - 351	IPR006638
domain	Radical SAM	82 - 372	IPR007197
domain	Radical SAM, C-terminal extension	312 - 392	IPR032432

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
elongator holoenzyme complex	A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
4 iron, 4 sulfur cluster binding	Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
acetyltransferase activity	Catalysis of the transfer of an acetyl group to an acceptor molecule.
metal ion binding	Binding to a metal ion.
phosphorylase kinase regulator activity	Modulation of the activity of the enzyme phosphorylase kinase.
tRNA binding	Binding to a transfer RNA.
tRNA uridine(34) acetyltransferase activity	Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine.

Name	Definition
central nervous system development	The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
neuron migration	The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
tRNA wobble uridine modification	The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02908	ELP3	Elongator complex protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2KJ61	ELP3	Elongator complex protein 3	Bos taurus (Bovine)	PR
Q5ZHS1	ELP3	Elongator complex protein 3	Gallus gallus (Chicken)	PR
Q9H9T3	ELP3	Elongator complex protein 3	Homo sapiens (Human)	PR
Q7X7L3	ELP3	Elongator complex protein 3	Oryza sativa subsp japonica (Rice)	PR
Q93ZR1	HAG3	Elongator complex protein 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NVL5	elp3	Elongator complex protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q5RIC0	elp3	Elongator complex protein 3	Danio rerio (Zebrafish) (Brachydanio rerio)	PR