Q2KJ61
PR
Gene name |
ELP3 |
Protein name |
Elongator complex protein 3 |
Names |
tRNA uridine(34) acetyltransferase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:784720 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KJ61
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KJ61-F1 | Predicted | AlphaFoldDB |
71 variants for Q2KJ61
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs436701526 | 4 | K>E | No | EVA | |
| rs436701526 | 4 | K>Q | No | EVA | |
| rs457299383 | 4 | K>R | No | EVA | |
| rs465282108 | 5 | R>G | No | EVA | |
| rs434870088 | 5 | R>H | No | EVA | |
| rs449082169 | 7 | G>C | No | EVA | |
| rs476461985 | 8 | D>A | No | EVA | |
| rs453855105 | 9 | L>P | No | EVA | |
| rs433085502 | 9 | L>V | No | EVA | |
| rs437680203 | 17 | L>V | No | EVA | |
| rs479053578 | 21 | D>H | No | EVA | |
| rs442131582 | 25 | Q>K | No | EVA | |
| rs462614474 | 26 | L>R | No | EVA | |
| rs470570765 | 28 | E>D | No | EVA | |
| rs454493366 | 31 | E>A | No | EVA | |
| rs440283800 | 31 | E>K | No | EVA | |
| rs469091904 | 33 | G>A | No | EVA | |
| rs441325913 | 58 | V>G | No | EVA | |
| rs462191971 | 62 | A>P | No | EVA | |
| rs439463071 | 68 | Y>C | No | EVA | |
| rs453672485 | 70 | K>E | No | EVA | |
| rs468308839 | 71 | V>G | No | EVA | |
| rs466842001 | 96 | P>H | No | EVA | |
| rs480975029 | 102 | I>S | No | EVA | |
| rs442562731 | 117 | D>G | No | EVA | |
| rs436826991 | 126 | S>F | No | EVA | |
| rs466947878 | 130 | Y>* | No | EVA | |
| rs481185021 | 133 | T>A | No | EVA | |
| rs448678102 | 133 | T>N | No | EVA | |
| rs481185021 | 133 | T>S | No | EVA | |
| rs477239844 | 138 | I>F | No | EVA | |
| rs3423265578 | 139 | R>H | No | EVA | |
| rs440366367 | 143 | D>A | No | EVA | |
| rs454902351 | 143 | D>E | No | EVA | |
| rs440366367 | 143 | D>G | No | EVA | |
| rs475579811 | 146 | L>M | No | EVA | |
| rs432263751 | 149 | R>S | No | EVA | |
| rs452878949 | 150 | H>P | No | EVA | |
| rs469792693 | 159 | G>C | No | EVA | |
| rs477912198 | 161 | S>R | No | EVA | |
| rs435675367 | 166 | E>K | No | EVA | |
| rs449802756 | 176 | A>D | No | EVA | |
| rs447527570 | 185 | F>Y | No | EVA | |
| rs448235362 | 224 | P>L | No | EVA | |
| rs481009305 | 236 | L>S | No | EVA | |
| rs449711249 | 247 | V>G | No | EVA | |
| rs464291190 | 250 | V>G | No | EVA | |
| rs469139909 | 257 | D>E | No | EVA | |
| rs452568701 | 283 | A>D | No | EVA | |
| rs467095927 | 285 | M>L | No | EVA | |
| rs436456180 | 291 | N>D | No | EVA | |
| rs450557019 | 292 | V>L | No | EVA | |
| rs461565695 | 297 | D>E | No | EVA | |
| rs442534727 | 297 | D>G | No | EVA | |
| rs438859201 | 300 | Q>* | No | EVA | |
| rs876380967 | 378 | V>G | No | EVA | |
| rs474436359 | 380 | H>L | No | EVA | |
| rs876605526 | 393 | D>A | No | EVA | |
| rs522488150 | 406 | V>L | No | EVA | |
| rs385647504 | 416 | R>W | No | EVA | |
| rs476732380 | 427 | Y>C | No | EVA | |
| rs209352961 | 484 | V>I | No | EVA | |
| rs446709025 | 524 | V>G | No | EVA | |
| rs460939117 | 528 | N>H | No | EVA | |
| rs481920833 | 532 | K>* | No | EVA | |
| rs439849936 | 533 | I>M | No | EVA | |
| rs454374246 | 534 | G>V | No | EVA | |
| rs437928266 | 543 | V>L | No | EVA | |
| rs452470803 | 545 | T>R | No | EVA | |
| rs481372391 | 547 | E>K | No | EVA | |
| rs515755547 | 548 | E>Y | No | EVA |
No associated diseases with Q2KJ61
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| elongator holoenzyme complex | A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| metal ion binding | Binding to a metal ion. |
| phosphorylase kinase regulator activity | Modulation of the activity of the enzyme phosphorylase kinase. |
| tRNA binding | Binding to a transfer RNA. |
| tRNA uridine(34) acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| central nervous system development | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. |
| neuron migration | The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation | The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine. |
| tRNA wobble uridine modification | The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02908 | ELP3 | Elongator complex protein 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZHS1 | ELP3 | Elongator complex protein 3 | Gallus gallus (Chicken) | PR |
| Q9H9T3 | ELP3 | Elongator complex protein 3 | Homo sapiens (Human) | PR |
| Q9CZX0 | Elp3 | Elongator complex protein 3 | Mus musculus (Mouse) | PR |
| Q7X7L3 | ELP3 | Elongator complex protein 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q93ZR1 | HAG3 | Elongator complex protein 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NVL5 | elp3 | Elongator complex protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q5RIC0 | elp3 | Elongator complex protein 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRQKRKGDLS | PAQLMMLTIG | DVIKQLIEAH | EQGKDIDLNK | VKTRTAAKYG | LSAQPRLVDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IAAVPPQYRK | VLVPKLKAKP | IRTASGIAVV | AVMCKPHRCP | HISFTGNICV | YCPGGPDSDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EYSTQSYTGY | EPTSMRAIRA | RYDPYLQTRH | RIEQLKQLGH | SVDKVEFIVM | GGTFMALPEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YRDYFIRNLH | DALSGHTSNN | IYEAVKYSER | SLTKCIGITI | ETRPDYCMKR | HLSDMLTYGC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TRLEIGVQSV | YEDVARDTNR | GHTVKAVCES | FHLAKDSGFK | VVAHMMPDLP | NVGLERDIEQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FTEFFENPAF | RPDGLKLYPT | LVIRGTGLYE | LWKSGRYKSY | SPSDLIELVA | RILALVPPWT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RVYRVQRDIP | MPLVSSGVEH | GNLRELAFAR | MKDLGIQCRD | VRTREVGIQE | IHHKVRPYQV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELVRRDYVAN | GGWETFLSYE | DPDQDILIGL | LRLRKCSEET | FRFELVGGVS | IVRELHVYGS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VVPVSSRDPT | KFQHQGFGML | LMEEAERIAR | EEHGSGKIAV | ISGVGTRNYY | RKIGYRLQGP |
| YMVKTLE |