Q02908
Gene name |
ELP3 |
Protein name |
Elongator complex protein 3 |
Names |
Gamma-toxin target 3, tRNA uridine(34) acetyltransferase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL086C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q02908
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6QK7 | EM | 330 A | C | 1-557 | PDB |
| 8ASV | EM | 435 A | C | 1-557 | PDB |
| 8ASW | EM | 396 A | C | 1-557 | PDB |
| AF-Q02908-F1 | Predicted | AlphaFoldDB |
3 variants for Q02908
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-385827 | 206 | N>S | No | SGRP | |
| s16-385537 | 303 | M>V | No | SGRP | |
| s16-385053 | 464 | K>M | No | SGRP |
No associated diseases with Q02908
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| elongator holoenzyme complex | A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
| metal ion binding | Binding to a metal ion. |
| tRNA binding | Binding to a transfer RNA. |
| tRNA uridine(34) acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation | The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine. |
| tRNA wobble uridine modification | The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJ61 | ELP3 | Elongator complex protein 3 | Bos taurus (Bovine) | PR |
| Q5ZHS1 | ELP3 | Elongator complex protein 3 | Gallus gallus (Chicken) | PR |
| Q9H9T3 | ELP3 | Elongator complex protein 3 | Homo sapiens (Human) | PR |
| Q9CZX0 | Elp3 | Elongator complex protein 3 | Mus musculus (Mouse) | PR |
| Q7X7L3 | ELP3 | Elongator complex protein 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q93ZR1 | HAG3 | Elongator complex protein 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NVL5 | elp3 | Elongator complex protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q5RIC0 | elp3 | Elongator complex protein 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARHGKGPKT | NKKKLAPEKE | RFIQCCADIT | LELTDSLTSG | TTREINLNGL | ITKYSKKYKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KQQPRLTDII | NSIPDQYKKY | LLPKLKAKPV | RTASGIAVVA | VMCKPHRCPH | IAYTGNICVY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CPGGPDSDFE | YSTQSYTGYE | PTSMRAIRAR | YDPYEQARGR | VEQLKQLGHS | IDKVEYVLMG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTFMSLPKEY | REDFIVKLHN | ALSGFNGNDI | DEAILYSQQS | LTKCVGITIE | TRPDYCTQTH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDDMLKYGCT | RLEIGVQSLY | EDVARDTNRG | HTVRSVCETF | AVSKDAGYKV | VSHMMPDLPN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VGMERDIEQF | KEYFENPDFR | TDGLKIYPTL | VIRGTGLYEL | WKTGRYKSYS | ANALVDLVAR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ILALVPPWTR | IYRVQRDIPM | PLVTSGVDNG | NLRELALARM | KDLGTTCRDV | RTREVGIQEV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HHKVQPDQVE | LIRRDYYANG | GWETFLSYED | PKKDILIGLL | RLRKASKKYT | YRKEFTSQRT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SIVRELHVYG | SVVPLHSRDP | RKFQHQGFGT | LLMEEAERIA | KEEHGSEKIS | VISGVGVRNY |
| 550 | |||||
| YGKLGYELDG | PYMSKRI |