Q93ZR1
PR
Gene name |
HAG3 |
Protein name |
Elongator complex protein 3 |
Names |
AtELP3, Elongator component 3, Protein ELONGATA 3, Protein ENHANCER-OF-ASYMMETRIC-LEAVES-TWO1, tRNA uridine(34) acetyltransferase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G50320 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q93ZR1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q93ZR1-F1 | Predicted | AlphaFoldDB |
17 variants for Q93ZR1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_20484789_T_C | 8 | N>S | No | 1000Genomes | |
| ENSVATH14621953 | 28 | T>S | No | 1000Genomes | |
| ENSVATH07389019 | 121 | A>G | No | 1000Genomes | |
| ENSVATH12683056 | 168 | S>N | No | 1000Genomes | |
| ENSVATH14621951 | 231 | T>A | No | 1000Genomes | |
| tmp_5_20483098_T_G | 252 | Q>H | No | 1000Genomes | |
| ENSVATH07389002 | 255 | I>S | No | 1000Genomes | |
| ENSVATH03404429 | 316 | M>L | No | 1000Genomes | |
| ENSVATH03404428 | 335 | I>L | No | 1000Genomes | |
| ENSVATH12683030 | 389 | M>L | No | 1000Genomes | |
| tmp_5_20482191_T_C | 436 | E>G | No | 1000Genomes | |
| ENSVATH00724659 | 461 | R>C | No | 1000Genomes | |
| ENSVATH12682989 | 476 | K>E | No | 1000Genomes | |
| ENSVATH07388992 | 478 | V>L | No | 1000Genomes | |
| tmp_5_20481476_C_G | 504 | G>A | No | 1000Genomes | |
| ENSVATH07388987 | 551 | L>F | No | 1000Genomes | |
| ENSVATH07388988 | 551 | L>W | No | 1000Genomes |
No associated diseases with Q93ZR1
8 regional properties for Q93ZR1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FERM domain | 43 - 327 | IPR000299 |
| domain | FERM adjacent | 336 - 380 | IPR014847 |
| domain | FERM, N-terminal | 47 - 109 | IPR018979 |
| domain | FERM, C-terminal PH-like domain | 239 - 331 | IPR018980 |
| conserved_site | FERM conserved site | 97 - 126 | IPR019747-1 |
| conserved_site | FERM conserved site | 205 - 234 | IPR019747-2 |
| domain | FERM central domain | 127 - 235 | IPR019748 |
| domain | Band 4.1 domain | 39 - 235 | IPR019749 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| elongator holoenzyme complex | A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. |
| euchromatin | A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| metal ion binding | Binding to a metal ion. |
| tRNA binding | Binding to a transfer RNA. |
| tRNA uridine(34) acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| DNA-mediated transformation | The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope. |
| organ growth | The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. |
| regulation of auxin mediated signaling pathway | Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin. |
| regulation of leaf formation | Any process that modulates the frequency, rate or extent of leaf formation. |
| specification of plant organ axis polarity | The process in which the polarity of a plant organ axis is specified. |
| tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation | The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine. |
| tRNA wobble uridine modification | The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02908 | ELP3 | Elongator complex protein 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2KJ61 | ELP3 | Elongator complex protein 3 | Bos taurus (Bovine) | PR |
| Q5ZHS1 | ELP3 | Elongator complex protein 3 | Gallus gallus (Chicken) | PR |
| Q9H9T3 | ELP3 | Elongator complex protein 3 | Homo sapiens (Human) | PR |
| Q9CZX0 | Elp3 | Elongator complex protein 3 | Mus musculus (Mouse) | PR |
| Q7X7L3 | ELP3 | Elongator complex protein 3 | Oryza sativa subsp japonica (Rice) | PR |
| Q6NVL5 | elp3 | Elongator complex protein 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q5RIC0 | elp3 | Elongator complex protein 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATAVVMNGE | LKKQPRPGKG | GYQGRGLTEE | EARVRAISEI | VSTMIERSHR | NENVDLNAIK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAACRKYGLA | RAPKLVEMIA | ALPDSERETL | LPKLRAKPVR | TASGIAVVAV | MSKPHRCPHI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATTGNICVYC | PGGPDSDFEY | STQSYTGYEP | TSMRAIRARY | NPYVQARSRI | DQLKRLGHSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DKVEFILMGG | TFMSLPAEYR | DFFIRNLHDA | LSGHTSANVE | EAVAYSEHSA | TKCIGMTIET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RPDYCLGPHL | RQMLIYGCTR | LEIGVQSTYE | DVARDTNRGH | TVAAVADCFC | LAKDAGFKVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AHMMPDLPNV | GVERDMESFK | EFFESPSFRA | DGLKIYPTLV | IRGTGLYELW | KTGRYRNYPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EQLVDIVARI | LSMVPPWTRV | YRVQRDIPMP | LVTSGVEKGN | LRELALARMD | DLGLKCRDVR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TREAGIQDIH | HKIKPEQVEL | VRRDYTANEG | WETFLSYEDT | RQDILVGLLR | LRKCGKNVTC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PELMGKCSVV | RELHVYGTAV | PVHGRDADKL | QHQGYGTLLM | EEAERIARRE | HRSNKIGVIS |
| 550 | 560 | ||||
| GVGTRHYYRK | LGYELEGPYM | VKHLL |