Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9CZD3

Entry ID Method Resolution Chain Position Source
AF-Q9CZD3-F1 Predicted AlphaFoldDB

41 variants for Q9CZD3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs227148055 6 P>L No EVA
rs240322012 21 P>L No EVA
rs3388826359 65 G>V No EVA
rs3388831840 67 F>L No EVA
rs3411268624 92 K>* No EVA
rs3388826945 100 L>V No EVA
rs3388837794 171 T>I No EVA
rs231412889 197 K>R No EVA
rs3388837827 255 S>F No EVA
rs3388815668 271 M>T No EVA
278 P>YK found in Nmf249 mice, a Charcot-Marie-Tooth 2D model; involved in neuromuscular dysfunction; contrary to the wild-type protein, strongly interacts with NRP1 and competes with VEGFA for NRP1-binding; no effect on subcellular location [UniProt] No
rs3388809463 302 L>V No EVA
rs3388797702 313 A>V No EVA
rs3388831368 329 G>A No EVA
rs3396711348 349 E>G No EVA
rs3396533797 350 K>I No EVA
rs3396711332 351 D>V No EVA
rs3396801077 352 H>L No EVA
rs3396776032 352 H>Y No EVA
rs3396850054 353 P>L No EVA
rs3388826316 375 Q>H No EVA
rs3388815736 390 V>E No EVA
rs3388829306 441 T>M No EVA
rs3396754245 480 K>E No EVA
rs3412999737 481 T>I No EVA
rs3388797684 487 F>I No EVA
rs3388826941 491 K>N No EVA
rs30101013 493 A>T No EVA
rs3388809512 546 V>I No EVA
rs3388831835 601 V>A No EVA
rs3396534949 655 G>A No EVA
rs3388831411 686 R>G No EVA
rs13465512 694 N>S No EVA
rs263735400 697 R>L No EVA
rs3388832945 699 L>V No EVA
rs30100034 701 N>K No EVA
rs30100036 707 A>V No EVA
rs248840688 708 D>E No EVA
rs3388797663 710 E>D No EVA
rs3388820800 712 R>T No EVA
rs3388820859 716 F>S No EVA

1 associated diseases with Q9CZD3

Without disease ID

5 regional properties for Q9CZD3

Type Name Position InterPro Accession
domain WHEP-TRS domain 53 - 112 IPR000738
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 285 - 350 IPR002314
domain Anticodon-binding 605 - 698 IPR004154
domain Aminoacyl-tRNA synthetase, class II 252 - 598 IPR006195
domain Glycyl-tRNA synthetase-like core domain 114 - 460 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
  • Mitochondrion
  • Cell projection, axon
  • Secreted
  • Secreted, extracellular exosome
  • Associated with granules in cultured neuron cells (By similarity)
  • Secreted by motor neuron and differentiated myotube cell lines, but not by undifferentiated myoblasts, possibly through the exosome pathway (PubMed:26503042)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
identical protein binding Binding to an identical protein or proteins.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

4 GO annotations of biological process

Name Definition
diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.
mitochondrial glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.
tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06817 GRS2 Glycine--tRNA ligase 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P38088 GRS1 Glycine--tRNA ligase 1, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P41250 GARS1 Glycine--tRNA ligase Homo sapiens (Human) PR
Q10039 gars-1 Glycine--tRNA ligase Caenorhabditis elegans PR
Q04451 GlyRS Glycine--tRNA ligase Bombyx mori (Silk moth) PR
Q9FXG2 At1g29870 Putative glycine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPCLLPSLLR ATRAALPLLS PPRVVAASAS QRLLSAPAQP AASRSSMDSA EELLAPLRLA
70 80 90 100 110 120
VRQQGDFVRK LKEDKAPQVD VDRAVAELKA RKRVLEAKEL ALQPKDDIVD RAKMEDTLKR
130 140 150 160 170 180
RFFYDQAFAI YGGVSGLYDF GPVGCALKNN IIQAWRQHFI QEEQILEIDC TMLTPEPVLK
190 200 210 220 230 240
TSGHVDKFAD FMVKDVKNGE CFRADHLLKA HLQKLMSDKK CSAEKKSEME SVLAQLDNYG
250 260 270 280 290 300
QQELADLFVN YNVKSPTTGN DLSPPVPFNL MFQTFIGPGG NMPGYLRPET AQGIFLNFKR
310 320 330 340 350 360
LLEFNQGKLP FAAAQIGNSF RNEISPRSGL IRVREFTMAE IEHFVDPTEK DHPKFQSVAD
370 380 390 400 410 420
LCLYLYSAKA QVTGQSARKM RLGDAVEQGV INNSVLGYFI GRIYLYLTKV GISPDKLRFR
430 440 450 460 470 480
QHMENEMAHY ACDCWDAESK TSYGWIEIVG CADRSCYDLS CHARATKVPL VAEKPLKEPK
490 500 510 520 530 540
TVNVVQFEPN KGAVGKAYKK DAKLVLEYLS ACDECYISEM ELLLSEKGEF TIETEGKTFQ
550 560 570 580 590 600
LTKDMVSVKR FQKTLHVEEV VPSVIEPSFG LGRIMYTILE HTFHVREGDE QRTFFSFPAV
610 620 630 640 650 660
VAPFKCSVLP LSQNQEFMPF VKELSEALTR NGVSHKVDDS SGSIGRRYAR TDEIGVAFGI
670 680 690 700 710 720
TIDFDTVNKT PHTATLRDRD SMRQIRAEVS ELPNVVRDLA NGNITWADVE ARYPLFEGQE
TGKKETVEE