Q06817
Gene name |
GRS2 (YPR081C) |
Protein name |
Glycine--tRNA ligase 2 |
Names |
Diadenosine tetraphosphate synthetase, Ap4A synthetase, Glycyl-tRNA synthetase 2, GlyRS 2, GlyRS2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR081C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06817
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06817-F1 | Predicted | AlphaFoldDB |
13 variants for Q06817
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-703863 | 36 | F>L | No | SGRP | |
| s16-703372 | 199 | L>F | No | SGRP | |
| s16-703280 | 230 | R>K | No | SGRP | |
| s16-703257 | 238 | E>K | No | SGRP | |
| s16-703204 | 255 | E>D | No | SGRP | |
| s16-703155 | 272 | G>S | No | SGRP | |
| s16-703028 | 314 | K>R | No | SGRP | |
| s16-702996 | 325 | N>D | No | SGRP | |
| s16-702660 | 437 | Q>E | No | SGRP | |
| s16-702576 | 465 | I>V | No | SGRP | |
| s16-702423 | 516 | G>S | No | SGRP | |
| s16-702401 | 523 | R>K | No | SGRP | |
| s16-702122 | 616 | V>A | No | SGRP |
No associated diseases with Q06817
1 regional properties for Q06817
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Domain unknown function DUF295 | 349 - 395 | IPR005174 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glycine-tRNA ligase activity | Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
| transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| diadenosine tetraphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. |
| glycyl-tRNA aminoacylation | The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. |
| mitochondrial glycyl-tRNA aminoacylation | The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38088 | GRS1 | Glycine--tRNA ligase 1, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P41250 | GARS1 | Glycine--tRNA ligase | Homo sapiens (Human) | PR |
| Q9CZD3 | Gars1 | Glycine--tRNA ligase | Mus musculus (Mouse) | PR |
| Q10039 | gars-1 | Glycine--tRNA ligase | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLMSNSERD | KLESTLRRRF | FYTPSFEIYG | GVSGLFDLGP | PGCQLQNNLI | RLWREHFIME |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENMLQVDGPM | LTPYDVLKTS | GHVDKFTDWM | CRNPKTGEYY | RADHLIEQTL | KKRLLDKDVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PQDMKNMEKI | LTTIDGFSGP | ELNLVMQEYN | INDPVTNDVL | DALTSFNLMF | ETKIGASGQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KAFLRPETAQ | GQFLNFNKLL | EINQGKIPFA | SASIGKSFRN | EISPRSGLLR | VREFLMAEIE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HFVDPLNKSH | AKFNEVLNEE | IPLLSRRLQE | SGEVQLPVKM | TIGEAVNSGM | VENETLGYFM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARVHQFLLNI | GINKDKFRFR | QHLKNEMAHY | ATDCWDGEIL | TSYGWIECVG | CADRAAFDLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VHSKKTGRSL | TVKQKLDTPK | ERTEWVVEVN | KKFFGSKFKQ | KAKLIESVLS | KFSQDELIRR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HEELEKNGEF | TCQVNGQIVK | LDSSLVTIKM | KTTLQHIREY | IPNVIEPSFG | LGRIIYCIFD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HCFQVRVDSE | SRGFFSFPLQ | IAPIKVFVTT | ISNNDGFPAI | LKRISQALRK | REIYFKIDDS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NTSIGKKYAR | NDELGTPFGI | TIDFETIKDQ | TVTLRERNSM | RQVRGTITDV | ISTIDKMLHN |
| 610 | |||||
| PDESDWDKST | FGLSPVKI |