Q10039

PR
Gene name
gars-1
Protein name
Glycine--tRNA ligase
Names
Diadenosine tetraphosphate synthetase, Ap4A synthetase, Glycyl-tRNA synthetase, GlyRS
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T10F2.1
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10039

Entry ID Method Resolution Chain Position Source
AF-Q10039-F1 Predicted AlphaFoldDB

No variants for Q10039

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10039

No associated diseases with Q10039

5 regional properties for Q10039

Type Name Position InterPro Accession
domain WHEP-TRS domain 73 - 132 IPR000738
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 305 - 600 IPR002314
domain Anticodon-binding 625 - 717 IPR004154
domain Aminoacyl-tRNA synthetase, class II 130 - 619 IPR006195
domain Glycyl-tRNA synthetase-like core domain 134 - 480 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
  • Cell projection, axon
  • Secreted
  • Secreted, extracellular exosome
  • Secreted by motor neuron, possibly through the exosome pathway
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

3 GO annotations of biological process

Name Definition
diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.
mitochondrial glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06817 GRS2 Glycine--tRNA ligase 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P38088 GRS1 Glycine--tRNA ligase 1, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P41250 GARS1 Glycine--tRNA ligase Homo sapiens (Human) PR
Q9CZD3 Gars1 Glycine--tRNA ligase Mus musculus (Mouse) PR
Q04451 GlyRS Glycine--tRNA ligase Bombyx mori (Silk moth) PR
Q9FXG2 At1g29870 Putative glycine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MFSSCWLKSS VRYSRLIRQF SSENSFFKVE LVPSDRKTPL QPRKVVAPRF EKKTRQKISD
70 80 90 100 110 120
YLKQMATPEI EAKLAPLRAA VKEYGDLIRD LKAKGAPKID IDKAVVELKA RKRLLEDTEI
130 140 150 160 170 180
ALAPKEASFD RLKLEDLLKR RFFYDQSFAI YGGVTGLYDF GPMGCSLKAN MLQEWRKHFI
190 200 210 220 230 240
LEEGMLEVDC TSLTPEPVLK ASGHVDRFAD WMVKDMKNGE CFRADHLIKN SIEKLLNDKK
250 260 270 280 290 300
TSAAVKQDGQ DVLARLEGFD NKDMHEVITR FNFKSPITGN DLTEPIAFNL MFPTQIGPTG
310 320 330 340 350 360
DFKAFLRPET AQGIFVNFKR LLEFNQGKLP FAAAQIGLGF RNEISPRQGL IRVREFTMCE
370 380 390 400 410 420
IEHFVDPEDK SLAKFAKVAD QKLVLFSACN QLDGAPAQEV AIGEAVAKKT VANETLGYYM
430 440 450 460 470 480
ARCHQFLMKV GIDGRRLRFR QHLSNEMAHY AQDCWDAEIL TSYGWIECVG NADRACYDLQ
490 500 510 520 530 540
QHYKATNVKL VAEKKLPEPV DVNFVEAQAN MALLGKSFKK DAKKIQTSLQ QLTSEQVSAL
550 560 570 580 590 600
EEELLAKKLY NLSVDGQNYA LTPEHLNIKK YTKKIHVQEI TPSVIEPSYG IGRIMYALLE
610 620 630 640 650 660
HSFRQREGDE QRTFLAFKPL VAPIKCSVLP ISANDTLIPV MDAVKEELSR FEMSYKVDDS
670 680 690 700 710 720
SGTIGRRYAR TDEIGIPFGI TVDFDSLKTT PFTVTIRHAE TMSQIRLEVS ELGRLISDLV
730 740
AGRQQWSDAQ AKYPKFEASA TE