Q9FXG2
PR
Gene name |
At1g29870 (F1N18.9) |
Protein name |
Putative glycine--tRNA ligase, cytoplasmic |
Names |
Diadenosine tetraphosphate synthetase, AP-4-A synthetase, Glycyl-tRNA synthetase, GlyRS |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G29870 |
EC number |
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FXG2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FXG2-F1 | Predicted | AlphaFoldDB |
85 variants for Q9FXG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00050711 | 6 | Q>* | No | 1000Genomes | |
| ENSVATH04669020 | 10 | R>W | No | 1000Genomes | |
| ENSVATH00050710 | 24 | G>E | No | 1000Genomes | |
| ENSVATH04669019 | 32 | A>G | No | 1000Genomes | |
| ENSVATH04669019 | 32 | A>V | No | 1000Genomes | |
| ENSVATH00050709 | 37 | N>D | No | 1000Genomes | |
| ENSVATH00050708 | 41 | E>Q | No | 1000Genomes | |
| ENSVATH01125832 | 43 | P>S | No | 1000Genomes | |
| ENSVATH00050707 | 49 | E>D | No | 1000Genomes | |
| ENSVATH12323326 | 52 | A>P | No | 1000Genomes | |
| ENSVATH01125831 | 54 | E>V | No | 1000Genomes | |
| ENSVATH04669017 | 57 | R>S | No | 1000Genomes | |
| tmp_1_10458578_C_A | 69 | D>Y | No | 1000Genomes | |
| tmp_1_10458574_C_G | 70 | R>P | No | 1000Genomes | |
| tmp_1_10458571_A_G | 71 | L>P | No | 1000Genomes | |
| ENSVATH00050705 | 82 | H>R | No | 1000Genomes | |
| ENSVATH04669015 | 87 | L>H | No | 1000Genomes | |
| ENSVATH00050703 | 92 | P>L | No | 1000Genomes | |
| tmp_1_10458500_G_A | 95 | R>C | No | 1000Genomes | |
| tmp_1_10458485_T_A | 100 | N>Y | No | 1000Genomes | |
| ENSVATH00050700 | 101 | I>V | No | 1000Genomes | |
| tmp_1_10458479_G_T | 102 | L>I | No | 1000Genomes | |
| ENSVATH12323254 | 103 | S>G | No | 1000Genomes | |
| ENSVATH04669014 | 103 | S>I | No | 1000Genomes | |
| ENSVATH04669011 | 116 | M>I | No | 1000Genomes | |
| ENSVATH12323251 | 120 | C>R | No | 1000Genomes | |
| tmp_1_10458334_G_A | 122 | A>V | No | 1000Genomes | |
| ENSVATH04669010 | 126 | E>V | No | 1000Genomes | |
| tmp_1_10458319_G_A | 127 | A>V | No | 1000Genomes | |
| ENSVATH01125827 | 129 | F>V | No | 1000Genomes | |
| ENSVATH00050698 | 133 | G>E | No | 1000Genomes | |
| ENSVATH12323250 | 137 | K>M | No | 1000Genomes | |
| tmp_1_10458288_C_A,CT | 137 | K>N | No | 1000Genomes | |
| ENSVATH04669009 | 141 | L>I | No | 1000Genomes | |
| tmp_1_10458261_C_G | 146 | E>D | No | 1000Genomes | |
| tmp_1_10458250_G_A | 150 | A>V | No | 1000Genomes | |
| tmp_1_10458206_G_A | 165 | R>* | No | 1000Genomes | |
| tmp_1_10458172_G_A | 176 | A>V | No | 1000Genomes | |
| tmp_1_10458156_T_G | 181 | K>N | No | 1000Genomes | |
| ENSVATH12323249 | 182 | V>F | No | 1000Genomes | |
| ENSVATH00050695 | 197 | V>A | No | 1000Genomes | |
| ENSVATH12323248 | 198 | W>R | No | 1000Genomes | |
| ENSVATH14001363 | 200 | H>L | No | 1000Genomes | |
| ENSVATH04669004 | 210 | P>L | No | 1000Genomes | |
| ENSVATH04669004 | 210 | P>R | No | 1000Genomes | |
| tmp_1_10458068_G_A | 211 | L>F | No | 1000Genomes | |
| ENSVATH04669003 | 221 | M>I | No | 1000Genomes | |
| ENSVATH14001362 | 230 | G>A | No | 1000Genomes | |
| tmp_1_10457916_G_A | 238 | P>L | No | 1000Genomes | |
| tmp_1_10457910_G_C | 240 | T>S | No | 1000Genomes | |
| ENSVATH04669000 | 241 | A>V | No | 1000Genomes | |
| tmp_1_10457850_G_A | 260 | P>L | No | 1000Genomes | |
| ENSVATH00050694 | 282 | R>G | No | 1000Genomes | |
| ENSVATH14001359 | 296 | H>R | No | 1000Genomes | |
| tmp_1_10457650_C_G | 298 | E>D | No | 1000Genomes | |
| tmp_1_10457648_T_C | 299 | H>R | No | 1000Genomes | |
| ENSVATH12323004 | 307 | D>N | No | 1000Genomes | |
| ENSVATH04668996 | 311 | L>I | No | 1000Genomes | |
| tmp_1_10457610_C_T | 312 | E>K | No | 1000Genomes | |
| ENSVATH00050693 | 313 | L>F | No | 1000Genomes | |
| tmp_1_10457582_T_A | 321 | Q>L | No | 1000Genomes | |
| ENSVATH00050692 | 325 | G>S | No | 1000Genomes | |
| tmp_1_10457549_C_G | 332 | C>S | No | 1000Genomes | |
| tmp_1_10457544_C_G | 334 | G>R | No | 1000Genomes | |
| tmp_1_10457436_G_A | 341 | H>Y | No | 1000Genomes | |
| ENSVATH12323000 | 345 | E>D | No | 1000Genomes | |
| ENSVATH01125823 | 349 | F>Y | No | 1000Genomes | |
| ENSVATH12322999 | 351 | I>F | No | 1000Genomes | |
| ENSVATH04668991 | 360 | R>H | No | 1000Genomes | |
| ENSVATH04668990 | 369 | R>H | No | 1000Genomes | |
| ENSVATH00050691 | 376 | N>T | No | 1000Genomes | |
| ENSVATH12322998 | 394 | Y>D | No | 1000Genomes | |
| tmp_1_10457249_G_A | 403 | A>V | No | 1000Genomes | |
| tmp_1_10457225_C_A | 411 | R>L | No | 1000Genomes | |
| tmp_1_10457226_G_T | 411 | R>S | No | 1000Genomes | |
| ENSVATH12322861 | 416 | K>I | No | 1000Genomes | |
| ENSVATH04668987 | 417 | S>I | No | 1000Genomes | |
| ENSVATH04668986 | 428 | A>T | No | 1000Genomes | |
| tmp_1_10457078_G_A | 430 | P>L | No | 1000Genomes | |
| ENSVATH14001356 | 437 | A>G | No | 1000Genomes | |
| ENSVATH12322859 | 445 | L>F | No | 1000Genomes | |
| tmp_1_10456957_C_T | 446 | G>D | No | 1000Genomes | |
| tmp_1_10456951_G_T | 448 | A>E | No | 1000Genomes | |
| ENSVATH04668985 | 448 | A>S | No | 1000Genomes | |
| ENSVATH04668984 | 456 | V>M | No | 1000Genomes |
No associated diseases with Q9FXG2
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.14 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glycine-tRNA ligase activity | Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| diadenosine tetraphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. |
| glycyl-tRNA aminoacylation | The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. |
| mitochondrial glycyl-tRNA aminoacylation | The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
4 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDAPEQSFLR | EKSLAVEDQE | LAVGTLEDSH | AAKPETNAAI | ELPNKSKPEK | SAVEKDREDF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REAVVKTLDR | LLFVHKSFDI | YHGVAGLYDF | GPHGRTVELN | ILSLWRKCFV | DEEDMMEVAC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TALTPEAVFN | ASGHVKKFTD | LMVKDEVDGA | FHRADHLVKS | YCENRKKDPT | ISAENAAELD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVIAHVEDLS | AEELGGVWNH | CSTAPVTKNP | LSHPPRPFNL | MFQTSFGASG | SLIGYLRPET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AQGSFCNFKD | YYNLNGRKLP | FAVAQVGRVF | RNEISPRQGL | LRTREFTLAE | IEHFVHPEHK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SHSKFSDVAK | LELLMFPREE | QEKPGQFAKR | LCLGEAVAKG | HVNSETLGFF | IGRVYLFLIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGIDKERLRF | RHHLANEMAH | YATDCWDAEI | ECSYGWIECV | GIADRSDYDL | RAHSEKSGHA |
| 430 | 440 | 450 | 460 | ||
| LVAQEKLAEP | IEVEKLAITP | EMKELGPAFK | GNQKNVVEAL | EVD |