Q04451

PR
Gene name
GlyRS
Protein name
Glycine--tRNA ligase
Names
Diadenosine tetraphosphate synthetase, Ap4A synthetase, Glycyl-tRNA synthetase
Species
Bombyx mori (Silk moth)
KEGG Pathway
bmor:692991
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04451

Entry ID Method Resolution Chain Position Source
AF-Q04451-F1 Predicted AlphaFoldDB

No variants for Q04451

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q04451

No associated diseases with Q04451

5 regional properties for Q04451

Type Name Position InterPro Accession
domain WHEP-TRS domain 61 - 120 IPR000738
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 294 - 588 IPR002314
domain Anticodon-binding 611 - 703 IPR004154
domain Aminoacyl-tRNA synthetase, class II 293 - 609 IPR006195
domain Glycyl-tRNA synthetase-like core domain 122 - 466 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • [Isoform 1]: Mitochondrion
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

2 GO annotations of biological process

Name Definition
diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41250 GARS1 Glycine--tRNA ligase Homo sapiens (Human) PR
Q9CZD3 Gars1 Glycine--tRNA ligase Mus musculus (Mouse) PR
Q10039 gars-1 Glycine--tRNA ligase Caenorhabditis elegans PR
Q9FXG2 At1g29870 Putative glycine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRHVLSLVYK CSVFSKQVTV FSNHLRLSHS QQWGSNKLHR KIKIPNPFRE IIMADPKIEE
70 80 90 100 110 120
ILAPLRANVK EQGDLVRKLK EEKAPEIDIK KAVAELKTRK KILEDKELSL APAEDLFDRA
130 140 150 160 170 180
KMEDLIKRRF FYDQSFAIYG GITGQFDFGP MGCALKSNMI HLWKKFFILQ EQMLEVECSI
190 200 210 220 230 240
LTPEPVLKAS GHVERFADLM TKDIKTGECF RLDHLIKGHL EKIKSDKNTK IELKAEIEDI
250 260 270 280 290 300
LIKLDGMNAD EMSALMKRFE MKSPISGNDL TPPIEFNLMF NTQIGPSGLV KGFLRPETAQ
310 320 330 340 350 360
GIFVNFKRLL EFNQGRLPFA AAQIGNSFRN EISPRSGLLR VREFTMCEIE HFCDVKEHPK
370 380 390 400 410 420
FESVKNTQSL LYSADNQEQG KPADLTTIGD AVCKGIVNNE TLGYFMARIH MYMLAVGIDP
430 440 450 460 470 480
KRLRFRQHMG NEMAHYACDC WDAECLSSYG WIECVGCADR SAYDLTQHTK ATGIRLAAEK
490 500 510 520 530 540
KLPAPKQIEV VEAIANNGRI GKAFKKDSQA INDTLATLDN AALEEMQKEL DSNGEYTLIT
550 560 570 580 590 600
ARGEFKLTPS LVNVKKTQKT IHVEEIIPSV IEPSFGVGRI LYCILEHNFR MREGDEQRTY
610 620 630 640 650 660
FSLPPTVAPM KCVVLPLSGN AEFQPFVRDL SQELITVDVS HKVDDSSGSI GRRYARTDEL
670 680 690 700 710 720
GVPYAVTVDF DTIKEPHTVT LRERDSMRQV RLPMADVPTV VRDLSNSKIL WSDVEQKYPK
730
FEQQETVKGT SV