P38088

PR
Gene name
GRS1 (YBR121C, YBR0917)
Protein name
Glycine--tRNA ligase 1, mitochondrial
Names
Diadenosine tetraphosphate synthetase, Ap4A synthetase, Glycyl-tRNA synthetase 1, GlyRS 1, GlyRS1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR121C
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38088

Entry ID Method Resolution Chain Position Source
AF-P38088-F1 Predicted AlphaFoldDB

No variants for P38088

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P38088

No associated diseases with P38088

1 regional properties for P38088

Type Name Position InterPro Accession
domain Methyltransferase domain 25 92 - 189 IPR041698

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • [Isoform Cytoplasmic]: Cytoplasm
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

4 GO annotations of biological process

Name Definition
diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached.
DNA-templated transcription termination The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.
mitochondrial glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06817 GRS2 Glycine--tRNA ligase 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P41250 GARS1 Glycine--tRNA ligase Homo sapiens (Human) PR
Q9CZD3 Gars1 Glycine--tRNA ligase Mus musculus (Mouse) PR
Q10039 gars-1 Glycine--tRNA ligase Caenorhabditis elegans PR
10 20 30 40 50 60
MSFFNISRRF YSQIVKKSVK IKRMSVEDIK KARAAVPFNR EQLESVLRGR FFYAPAFDLY
70 80 90 100 110 120
GGVSGLYDYG PPGCAFQNNI IDAWRKHFIL EEDMLEVDCT MLTPYEVLKT SGHVDKFSDW
130 140 150 160 170 180
MCRDLKTGEI FRADHLVEEV LEARLKGDQE ARGLVEDANA AAKDDAEKKK RKKKVKQIKA
190 200 210 220 230 240
VKLDDDVVKE YEEILAKIDG YSGPELGELM EKYDIGNPVT GETLESPRAF NLMFETAIGP
250 260 270 280 290 300
SGQLKGYLRP ETAQGQFLNF NKLLEFNNSK TPFASASIGK SFRNEISPRA GLLRVREFLM
310 320 330 340 350 360
AEIEHFVDPL DKSHPKFNEI KDIKLSFLPR DVQEAGSTEP IVKTVGEAVA SRMVDNETLG
370 380 390 400 410 420
YFIARIYQFL MKIGVDESKL RFRQHMANEM AHYAADCWDG ELKTSYGWIE CVGCADRSAY
430 440 450 460 470 480
DLTVHSKKTK EKLVVRQKLD NPIEVTKWEI DLTKKLFGPK FRKDAPKVES HLLNMSQDDL
490 500 510 520 530 540
ASKAELLKAN GKFTIKVDGV DGEVELDDKL VKIEQRTKVE HVREYVPSVI EPSFGIGRII
550 560 570 580 590 600
YSVFEHSFWN RPEDNARSVL SFPPLVAPTK VLLVPLSNHK DLVPVTTEVA KILRKSQIPF
610 620 630 640 650 660
KIDDSGVSIG KRYARNDELG TPFGVTIDFE SAKDHSVTLR ERDSTKQVRG SVENVIKAIR
670 680
DITYNGASWE EGTKDLTPFI AQAEAEAETD