Q9CWK8
PR
Gene name |
Snx2 |
Protein name |
Sorting nexin-2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67804 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CWK8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CWK8-F1 | Predicted | AlphaFoldDB |
13 variants for Q9CWK8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389506209 | 50 | E>K | No | EVA | |
| rs3389412811 | 148 | D>E | No | EVA | |
| rs3407506867 | 177 | E>SSFD* | No | EVA | |
| rs3389450883 | 200 | H>L | No | EVA | |
| rs3412695529 | 262 | L>W | No | EVA | |
| rs3389511354 | 377 | L>S | No | EVA | |
| rs3389515087 | 380 | E>D | No | EVA | |
| rs3389511361 | 386 | F>L | No | EVA | |
| rs13464275 | 434 | M>L | No | EVA | |
| rs3389517353 | 482 | R>* | No | EVA | |
| rs3389515152 | 490 | I>F | No | EVA | |
| rs3389511376 | 493 | Y>* | No | EVA | |
| rs3408195542 | 504 | L>* | No | EVA |
No associated diseases with Q9CWK8
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| retromer complex | A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. |
| retromer, tubulation complex | The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| epidermal growth factor receptor binding | Binding to an epidermal growth factor receptor. |
| identical protein binding | Binding to an identical protein or proteins. |
| insulin receptor binding | Binding to an insulin receptor. |
| leptin receptor binding | Binding to a leptin receptor. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| transferrin receptor binding | Binding to a transferrin receptor. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| early endosome to Golgi transport | The directed movement of substances from early endosomes to the Golgi. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lamellipodium morphogenesis | A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05B62 | SNX1 | Sorting nexin-1 | Bos taurus (Bovine) | PR |
| Q3ZBM5 | SNX5 | Sorting nexin-5 | Bos taurus (Bovine) | PR |
| O95219 | SNX4 | Sorting nexin-4 | Homo sapiens (Human) | PR |
| Q13596 | SNX1 | Sorting nexin-1 | Homo sapiens (Human) | PR |
| O60749 | SNX2 | Sorting nexin-2 | Homo sapiens (Human) | PR |
| Q9Y5X3 | SNX5 | Sorting nexin-5 | Homo sapiens (Human) | PR |
| Q9WV80 | Snx1 | Sorting nexin-1 | Mus musculus (Mouse) | PR |
| Q99N27 | Snx1 | Sorting nexin-1 | Rattus norvegicus (Rat) | PR |
| Q9FG38 | SNX1 | Sorting nexin 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAEREPPPL | GDVKPTDFEE | LEDGEDLFTS | TVSTLESSPS | SPEPASLPAE | DISANSNGSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PVEVVLDDDR | EDLFAEATEE | VSLDSPEREL | ILSSEPSPAV | TPVTPTTLIA | PRIESKSISA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVIFDRSRDE | IEEEANGDIF | DIEIGVSDPE | KVGDGMNAYM | AYRVTTKTSL | SMFSKSEFSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRRFSDFLGL | HSKLASKYLH | VGYIVPPAPE | KSIVGMTKVK | VGKEDSSSTE | FVEKRRAALE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RYLQRTVKHP | TLLQDPDLRQ | FLESSELPRA | VNTQALSGAG | ILRMVNKAAD | AVNKMTIKMN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESDAWFEEKQ | QQFENLDQQL | RKLHASVEAL | VCHRKELSAN | TAAFAKSAAM | LGNSEDHTAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SRALSQLAEV | EEKIDQLHQE | QAFADFYMFS | ELLSDYIRLI | AAVKGVFDHR | MKCWQKWEDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QITLLKKRET | EAKMMVANKP | DKIQQAKNEI | REWEAKVQQG | ERDFEQISKT | IRKEVGRFEK |
| 490 | 500 | 510 | |||
| ERVKDFKAVI | IKYLESLVQT | QQQLIKYWEA | FLPEAKAIA |