AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3ZBM5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs483225145	7	V>A	No	EVA
rs462374598	57	T>M	No	EVA
rs443893090	59	Q>E	No	EVA
rs476974829	61	P>R	No	EVA
rs452038036	66	T>R	No	EVA
rs439196187	67	R>S	No	EVA
rs472188985	68	Q>E	No	EVA
rs453784315	69	H>Y	No	EVA
rs468392845	72	F>C	No	EVA
rs468392845	72	F>S	No	EVA
rs435319225	72	F>V	No	EVA
rs456303823	74	W>R	No	EVA
rs464265458	77	D>E	No	EVA
rs437808742	77	D>V	No	EVA
rs445909801	78	T>P	No	EVA
rs433108369	80	I>L	No	EVA
rs466044402	81	E>*	No	EVA
rs447754233	83	T>P	No	EVA
rs480807717	84	D>V	No	EVA
rs473232146	95	T>P	No	EVA
rs454701528	97	P>T	No	EVA
rs475004952	108	K>N	No	EVA
rs456556959	111	E>A	No	EVA
rs438089490	116	M>V	No	EVA
rs464631238	120	E>*	No	EVA
rs464631238	120	E>K	No	EVA
rs452632044	124	M>R	No	EVA
rs434127309	126	Q>K	No	EVA
rs441323144	127	E>Q	No	EVA
rs448680947	127	E>V	No	EVA
rs481799088	130	A>E	No	EVA
rs481799088	130	A>V	No	EVA
rs463759901	137	K>R	No	EVA
rs209706136	149	R>W	No	EVA
rs132824422	150	L>F	No	EVA
rs109888536	152	S>P	No	EVA
rs207965191	182	M>V	No	EVA
rs437287196	215	F>L	No	EVA
rs208117943	216	L>P	No	EVA
rs467256538	237	H>D	No	EVA
rs448035008	238	K>Q	No	EVA
rs480823001	238	K>T	No	EVA
rs441997330	246	H>P	No	EVA
rs456618374	247	T>N	No	EVA
rs475011667	247	T>P	No	EVA
rs475011667	247	T>S	No	EVA
rs471156824	253	S>R	No	EVA
rs467241979	261	V>D	No	EVA
rs208080490	292	T>A	No	EVA
rs133326433	310	Y>S	No	EVA
rs439311059	334	R>K	No	EVA
rs437182336	362	I>M	No	EVA
rs470229315	365	K>N	No	EVA
rs445366695	372	F>L	No	EVA
rs478445967	374	K>N	No	EVA
rs466412208	376	L>V	No	EVA
rs447967266	378	E>D	No	EVA
rs480878954	381	E>*	No	EVA
rs462466039	381	E>A	No	EVA
rs443195730	384	I>M	No	EVA
rs482682389	385	K>*	No	EVA
rs482682389	385	K>E	No	EVA
rs457757511	388	R>S	No	EVA

Type	Name	Position	InterPro Accession
domain	Phox homology	25 - 172	IPR001683
domain	Sorting nexin/Vps5-like, C-terminal	180 - 391	IPR015404
domain	Sorting nexin-5, BAR domain	185 - 402	IPR028654
domain	SNX5, PX domain	29 - 169	IPR042135

		Description
EC Number
Subcellular Localization	Endosome Early endosome Early endosome membrane ; Peripheral membrane protein; Cytoplasmic side Cell membrane ; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm Cell projection, phagocytic cup Cell projection, ruffle	Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) Detected on macropinosomes Targeted to membrane ruffles in response to EGFR stimulation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane	The lipid bilayer surrounding an early endosome.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
extrinsic component of cytoplasmic side of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
extrinsic component of endosome membrane	The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
macropinocytic cup	A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.
phagocytic cup	An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

Name	Definition
dynactin binding	Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity.
phosphatidylinositol binding	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

Name	Definition
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
pinocytosis	An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y5X3	SNX5	Sorting nexin-5	Homo sapiens (Human)	PR
O60749	SNX2	Sorting nexin-2	Homo sapiens (Human)	PR
Q13596	SNX1	Sorting nexin-1	Homo sapiens (Human)	PR
Q9CWK8	Snx2	Sorting nexin-2	Mus musculus (Mouse)	PR
Q99N27	Snx1	Sorting nexin-1	Rattus norvegicus (Rat)	PR