AiPD: Autoinhibited Protein Database

Q13596

Gene name	SNX1
Protein name	Sorting nexin-1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6642
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-166 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-166 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for Q13596

Entry ID	Method	Resolution	Chain	Position	Source
2I4K	NMR	-	A	142-269	PDB
4FZS	X-ray	280 A	A/B	301-522	PDB
8A1G	X-ray	250 A	A/B	301-522	PDB
8ABQ	X-ray	281 A	A/B	301-522	PDB
8AFZ	EM	1000 A	A	1-522	PDB
AF-Q13596-F1	Predicted				AlphaFoldDB

411 variants for Q13596

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1466115965 CA392814310	2	A>T		No	ClinGen TOPMed gnomAD
CA392814320 rs1302801480	2	A>V		No	ClinGen gnomAD
rs779691030 CA7607556	3	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1315517456 CA392814340	4	G>S		No	ClinGen gnomAD
rs754960914 CA7607559	5	G>D		No	ClinGen ExAC gnomAD
rs367760878 CA7607558	5	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1486113842 CA392814372	6	G>D		No	ClinGen gnomAD
rs1236864650 CA392814366	6	G>S		No	ClinGen gnomAD
CA392814379 rs1390021579	7	G>C		No	ClinGen TOPMed
rs1046442862 CA272161450	8	C>R		No	ClinGen TOPMed
CA272161452 rs935644420	8	C>Y		No	ClinGen TOPMed
rs1477521315 CA392814414	9	S>G		No	ClinGen gnomAD
rs769590422 CA7607562	9	S>I		No	ClinGen ExAC gnomAD
CA392814420 rs769590422	9	S>N		No	ClinGen ExAC gnomAD
CA7607563 rs777522910	9	S>R		No	ClinGen ExAC TOPMed gnomAD
CA7607564 rs748857822	10	A>D		No	ClinGen ExAC TOPMed gnomAD
CA392814440 rs1413154900	10	A>P		No	ClinGen gnomAD
CA392814436 rs1413154900	10	A>T		No	ClinGen gnomAD
rs748857822 CA272161475	10	A>V		No	ClinGen ExAC TOPMed gnomAD
rs775717942 CA7607566	11	S>L		No	ClinGen ExAC TOPMed gnomAD
CA7607569 rs140656810	12	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	12	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7607568 rs140656810	12	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs761251263 CA7607567	12	E>K		No	ClinGen ExAC TOPMed gnomAD
CA272161485 rs761251263	12	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs140656810 CA7607570	12	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs370223175 CA392814511	14	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs144432300 CA7607573	15	P>L		No	ClinGen ESP ExAC gnomAD
rs777617638 CA7607572	15	P>S		No	ClinGen ExAC TOPMed gnomAD
CA392814562 rs1370505535	16	P>R		No	ClinGen TOPMed
CA7607574 rs201234536	16	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392814582 rs1217920055	17	P>L		No	ClinGen gnomAD
rs1217920055 CA392814579	17	P>R		No	ClinGen gnomAD
CA272161511 rs151109030	17	P>S		No	ClinGen ESP gnomAD
rs754975675 COSM3981603 CA392814626	19	P>L	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs754975675 CA7607576	19	P>R		No	ClinGen ExAC gnomAD
CA392814618 rs1200188674	19	P>S		No	ClinGen gnomAD
rs1200188674 CA392814614	19	P>T		No	ClinGen gnomAD
CA392814632 rs1477131412	20	G>R		No	ClinGen gnomAD
CA392814655 rs1402771287	22	E>K		No	ClinGen gnomAD
rs1360390894 CA392814694	23	P>Q		No	ClinGen gnomAD
CA7607579 rs201468224	24	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	25	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392814764 rs1332473886	26	E>*		No	ClinGen gnomAD
TCGA novel	26	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1332473886 CA392814759	26	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7607580 rs777138062	27	G>A		No	ClinGen ExAC gnomAD
rs1433917082 CA392814784	27	G>R		No	ClinGen TOPMed gnomAD
rs200363020 CA7607581	28	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA272161566 rs575758638	28	A>V		No	ClinGen Ensembl
TCGA novel	29	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392814831 rs1352814254	29	A>V		No	ClinGen gnomAD
CA7607583 rs780484362	30	G>R		No	ClinGen ExAC gnomAD
CA272161589 rs780484362	30	G>W		No	ClinGen ExAC gnomAD
CA7607584 rs747288155	31	G>E		No	ClinGen ExAC TOPMed gnomAD
CA392814853 rs1449934975	31	G>R		No	ClinGen TOPMed gnomAD
CA392814895 rs1439395754	32	S>L		No	ClinGen TOPMed
CA272161598 rs769183939	34	P>H		No	ClinGen ExAC TOPMed gnomAD
CA7607585 rs769183939	34	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1177115717 CA392814973	36	A>G		No	ClinGen gnomAD
rs773160874 CA7607589	37	G>A		No	ClinGen ExAC gnomAD
CA7607588 rs769918313	37	G>R		No	ClinGen ExAC gnomAD
CA392814995 rs1294536431	38	D>N		No	ClinGen TOPMed
TCGA novel	38	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs967106242 CA272161607	43	G>R		No	ClinGen Ensembl
CA392815109 rs759362417	44	E>D		No	ClinGen ExAC TOPMed gnomAD
rs774215652 CA7607592	44	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	44	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392815151 rs1323133961	47	F>S		No	ClinGen TOPMed
rs372800532 CA7607594	48	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA392815188 rs1306736193	50	A>V		No	ClinGen gnomAD
rs1165698776 CA392815198	51	A>G		No	ClinGen TOPMed
CA392815207 rs1456816283	52	V>E		No	ClinGen TOPMed
TCGA novel	54	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392818416 rs1488757916	55	K>E		No	ClinGen TOPMed
rs759807032 CA7607610	56	H>P		No	ClinGen ExAC gnomAD
rs1320072430 CA392818438	56	H>Y		No	ClinGen gnomAD
rs141106971 CA272175267 CA392818495	57	Q>H		No	ClinGen ESP TOPMed gnomAD
CA7607611 rs767490689	57	Q>R		No	ClinGen ExAC gnomAD
CA392818506 rs1202507870	59	P>A		No	ClinGen gnomAD
rs775360838 CA7607612	60	K>T		No	ClinGen ExAC gnomAD
rs753420175 CA7607615	61	I>K		No	ClinGen ExAC gnomAD
rs763892941 CA7607614	61	I>V		No	ClinGen ExAC TOPMed gnomAD
CA392818553 rs1314087998	62	T>A		No	ClinGen TOPMed
CA272175288 rs374702600	63	T>A		No	ClinGen ESP TOPMed
rs1478499392 CA392818580	64	S>A		No	ClinGen gnomAD
rs1219795209 CA392818596	65	L>F		No	ClinGen TOPMed
rs761270016 CA7607617 COSM193597	67	P>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs750135323 CA7607618	67	P>H		No	ClinGen ExAC gnomAD
rs761270016 CA392818621	67	P>S		No	ClinGen ExAC TOPMed gnomAD
rs761270016 CA7607616	67	P>T		No	ClinGen ExAC TOPMed gnomAD
CA392818629 rs1399995922	68	I>F		No	ClinGen gnomAD
CA7607621 rs753001540	69	N>K		No	ClinGen ExAC TOPMed gnomAD
rs781539376 CA7607620	69	N>S		No	ClinGen ExAC gnomAD
CA272175309 rs150183282	72	S>C		No	ClinGen ESP TOPMed gnomAD
rs765271417 CA7607622	73	K>E		No	ClinGen ExAC gnomAD
CA272175315 rs907807186	75	N>D		No	ClinGen TOPMed
rs138725192 CA7607623	76	G>A		No	ClinGen ESP ExAC TOPMed
CA7607625 rs770962999	77	I>F		No	ClinGen ExAC TOPMed gnomAD
rs1235910793 CA392818769	77	I>N		No	ClinGen gnomAD
rs1254689405 CA392818778	78	H>N		No	ClinGen gnomAD
CA392818784 rs1344748296	78	H>P		No	ClinGen TOPMed gnomAD
CA392818786 rs1344748296	78	H>R		No	ClinGen TOPMed gnomAD
CA392818813 rs1422058548	80	E>K		No	ClinGen TOPMed
rs377404172 CA272175329	81	Q>E		No	ClinGen ESP
CA392818911 rs1173278342	85	P>S		No	ClinGen TOPMed
CA392818924 rs1478386739	86	Q>*		No	ClinGen TOPMed
TCGA novel	86	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392818920 rs1478386739	86	Q>K		No	ClinGen TOPMed
CA7607655 rs747232429	91	D>E		No	ClinGen ExAC gnomAD
TCGA novel	92	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7607656 rs768395868	94	V>M		No	ClinGen ExAC gnomAD
rs761660161 CA7607658	95	E>G		No	ClinGen ExAC TOPMed gnomAD
rs776483256 CA7607657	95	E>Q		No	ClinGen ExAC gnomAD
rs1482440668 CA392820074	99	D>N		No	ClinGen TOPMed
rs1466389480 CA392820088	100	S>R		No	ClinGen TOPMed gnomAD
CA392820091 rs1567323913	101	T>A		No	ClinGen Ensembl
rs186954122 CA7607659	103	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1206654268 CA392820116	104	N>I		No	ClinGen gnomAD
rs1303952606 CA392820122	105	Q>P		No	ClinGen gnomAD
rs1381918495 CA392820139	107	K>R		No	ClinGen gnomAD
CA392820144 rs762409802	108	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7607661 rs762409802	108	V>M		No	ClinGen ExAC TOPMed gnomAD
CA392820164 rs1294099573	111	K>R		No	ClinGen TOPMed
rs1049501 CA392820190	115	S>F		No	ClinGen TOPMed gnomAD
CA272177231 rs1049501 VAR_052477	115	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen UniProt NCI-TCGA TOPMed dbSNP gnomAD
CA272177233 rs1021544217	117	P>S		No	ClinGen Ensembl
CA7607664 rs759211566	118	P>L		No	ClinGen ExAC gnomAD
CA392820215 rs1197738473	120	E>K		No	ClinGen gnomAD
rs764430840 CA7607665	120	E>V		No	ClinGen ExAC gnomAD
CA392820235 rs1306118042	123	N>D		No	ClinGen TOPMed
rs147060442 CA272177236	124	S>C		No	ClinGen ESP
rs138423671 CA7607666	125	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs1199521055 CA392820275	129	P>A		No	ClinGen gnomAD
rs200079069 CA392820277	129	P>L		No	ClinGen ExAC TOPMed gnomAD
rs200079069 CA7607669	129	P>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7607670 rs765803225	130	T>A		No	ClinGen ExAC gnomAD
CA392820288 rs1361249309	131	Y>C		No	ClinGen gnomAD
CA392820285 rs1177151327	131	Y>H		No	ClinGen gnomAD
rs780268818 CA7607673	133	E>D		No	ClinGen ExAC gnomAD
CA7607701 rs770784911	140	E>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7607703 rs745345629	141	D>E		No	ClinGen ExAC gnomAD
rs1334953756 CA392820374	141	D>V		No	ClinGen TOPMed
CA7607704 rs368778345	143	F>C		No	ClinGen ESP ExAC gnomAD
rs904337775 CA272177375	146	T>A		No	ClinGen Ensembl
CA392820480 rs1236227669	146	T>I		No	ClinGen TOPMed
rs770349136 CA7607708	148	G>R		No	ClinGen ExAC TOPMed gnomAD
rs770349136 CA7607707	148	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs968498504 CA272177380	149	I>L		No	ClinGen TOPMed
rs763569564 CA7607709	152	P>A		No	ClinGen ExAC TOPMed gnomAD
CA7607710 rs766859700	153	E>Q		No	ClinGen ExAC gnomAD
CA7607711 rs751620305	155	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1232939902 CA392821612	157	D>N		No	ClinGen gnomAD
CA392821616 rs1232939902	157	D>Y		No	ClinGen gnomAD
rs1035097807 CA272178508	159	M>I		No	ClinGen Ensembl
CA7607730 rs774971028	162	Y>*		No	ClinGen ExAC gnomAD
rs574871557 CA7607731	163	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1443434687 CA392821720	170	Q>*		No	ClinGen TOPMed gnomAD
rs1443434687 CA392821719	170	Q>E		No	ClinGen TOPMed gnomAD
TCGA novel	170	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1399928802 CA392822048	172	S>N		No	ClinGen TOPMed gnomAD
rs142792307 CA7607755	172	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7607757 rs750128841	173	L>S		No	ClinGen ExAC gnomAD
TCGA novel	176	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	177	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7607758 rs566105118	180	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766377028 CA7607759 CA7607760	181	F>L		No	ClinGen ExAC gnomAD
TCGA novel	181	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1333150637 CA392822249	183	V>I		No	ClinGen TOPMed
rs1432464483 CA392822266	184	K>R		No	ClinGen TOPMed
rs1347722595 CA392822292	187	F>Y		No	ClinGen TOPMed gnomAD
rs754583956 CA7607761	188	S>N		No	ClinGen ExAC gnomAD
CA392822321 rs149753651	191	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs747897527 CA7607763	191	L>P		No	ClinGen ExAC gnomAD
CA7607762 rs149753651	191	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs908015912 CA272179114	192	G>D		No	ClinGen TOPMed
rs755651604 CA7607764	194	Y>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	197	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7607765 rs779345580	199	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1237253649 CA392822380	200	K>T		No	ClinGen TOPMed
CA392822402 rs1362579634	203	Q>P		No	ClinGen TOPMed gnomAD
rs200154930 CA7607768	204	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1204465320 CA392822423	206	F>Y		No	ClinGen TOPMed
rs1288543769 CA392822445	209	P>L		No	ClinGen gnomAD
CA392822452 rs1306881491	210	P>L		No	ClinGen TOPMed
rs1388900478 CA392822463	212	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1312066405 CA392822484	215	S>N		No	ClinGen gnomAD
rs765330212 CA7607773	216	L>F		No	ClinGen ExAC TOPMed gnomAD
rs967373708 CA272179130	217	I>T		No	ClinGen Ensembl
rs774219147 CA7607795	219	M>T		No	ClinGen ExAC gnomAD
CA7607794 rs770916921	219	M>V		No	ClinGen ExAC gnomAD
rs759556508 CA7607796	224	V>I		No	ClinGen ExAC TOPMed gnomAD
rs977537377 CA272179383	225	G>R		No	ClinGen TOPMed gnomAD
rs977537377 CA392822559	225	G>W		No	ClinGen TOPMed gnomAD
rs1461982396 CA392822566	226	K>M		No	ClinGen TOPMed gnomAD
CA7607797 rs767509497	227	E>K		No	ClinGen ExAC gnomAD
CA7607798 rs1555492288	228	D>V		No	ClinGen Ensembl
CA7607801 rs535080872	229	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374560896 CA7607800	229	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs535080872 CA392822587	229	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392822592 rs1291064201	230	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA392822598 rs1354368914	231	S>Y		No	ClinGen gnomAD
rs1312836943 CA392822604	232	A>E		No	ClinGen TOPMed
rs985002276 CA272179390	236	E>G		No	ClinGen TOPMed
rs763649714 CA7607802	236	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs985002276 CA392822632	236	E>V		No	ClinGen TOPMed
CA7607803 rs753505220	237	K>R		No	ClinGen ExAC gnomAD
rs756840245 CA7607804	238	R>Q		No	ClinGen ExAC gnomAD
rs1305522790 CA392822643	238	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	239	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1370512858 CA392822655	240	A>T		No	ClinGen TOPMed
CA7607806 rs751872912	240	A>V		No	ClinGen ExAC TOPMed gnomAD
CA392822659 rs781592699	241	A>S		No	ClinGen ExAC TOPMed gnomAD
CA7607808 rs781592699	241	A>T		No	ClinGen ExAC TOPMed gnomAD
rs765320488 CA392822669	242	L>F		No	ClinGen ExAC gnomAD
rs867201745 CA272179400	243	E>G		No	ClinGen Ensembl
CA392822704 rs761479506	246	L>F		No	ClinGen ExAC TOPMed gnomAD
CA7607822 rs761479506	246	L>I		No	ClinGen ExAC TOPMed gnomAD
CA7607824 rs750049013	247	Q>H		No	ClinGen ExAC gnomAD
CA7607823 rs764832367	247	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1419724753 CA392822725	249	I>T		No	ClinGen gnomAD
rs755383058 CA7607825	250	V>I		No	ClinGen ExAC TOPMed gnomAD
CA392822738 rs1245670187	251	N>S		No	ClinGen TOPMed
rs909296208 CA272179632	252	H>R		No	ClinGen Ensembl
rs1319918419 CA392822961	255	M>V		No	ClinGen gnomAD
rs368141275 CA7607826	259	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs567291724 CA7607828	260	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777728260 CA7607829	261	V>I		No	ClinGen ExAC TOPMed gnomAD
CA7607831 rs757582732	263	E>D		No	ClinGen ExAC gnomAD
rs749331073 CA392823073	263	E>G		No	ClinGen ExAC gnomAD
TCGA novel	263	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7607830 rs749331073	263	E>V		No	ClinGen ExAC gnomAD
rs139810506 CA7607849	271	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1374020 rs111801077 CA7607850	272	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs779132736 CA7607851	272	R>H		No	ClinGen ExAC TOPMed gnomAD
rs758590042 CA392823412	274	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7607853 rs758590042	274	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1469160972 CA392823458	278	T>A		No	ClinGen gnomAD
rs376805248 CA7607855	278	T>I		No	ClinGen ESP ExAC gnomAD
rs1412121843 CA392823503	281	G>A		No	ClinGen TOPMed
rs748062141 CA392823521	283	G>C		No	ClinGen ExAC TOPMed gnomAD
rs748062141 CA7607858	283	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1276193567 CA392823537	284	L>P		No	ClinGen Ensembl
rs368998210 CA7607859	285	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs368998210 CA7607860	285	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1254948603 CA392823551	286	K>*		No	ClinGen TOPMed gnomAD
rs775748393 CA7607864	294	A>G		No	ClinGen ExAC gnomAD
CA7607866 rs764341196	295	V>I		No	ClinGen ExAC TOPMed gnomAD
CA272180161 rs1043746738	298	M>I		No	ClinGen Ensembl
TCGA novel	299	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1388017759 CA392823748	301	K>R		No	ClinGen TOPMed
CA392823770 rs1232882418	304	E>Q		No	ClinGen gnomAD
CA7607869 rs765420997	305	S>L		No	ClinGen ExAC gnomAD
rs201402325 CA7607868	305	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7607870 rs750481322	307	I>F		No	ClinGen ExAC gnomAD
CA392823908 rs1318159029	310	E>G		No	ClinGen gnomAD
CA7607896 rs201043143	313	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392823961 rs1301816547	314	Q>*		No	ClinGen gnomAD
rs1232845300 CA392824020	318	C>R		No	ClinGen gnomAD
CA392824027 rs1260962035	318	C>S		No	ClinGen gnomAD
rs1435505027 CA392824059	320	E>G		No	ClinGen gnomAD
CA7607900 COSM1227032 rs778221788	322	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA392824088 rs1364656212	322	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs771802227 CA7607902	324	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7607901 rs146206725	324	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs777167206 CA392824146	326	L>V		No	ClinGen ExAC gnomAD
CA7607905 rs770264981	327	H>P		No	ClinGen ExAC gnomAD
CA272180238 rs372898013	329	V>L		No	ClinGen ESP TOPMed gnomAD
CA392824219 rs1567330682	330	V>L		No	ClinGen Ensembl
CA7607907 rs763368039	331	E>A		No	ClinGen ExAC gnomAD
CA7607908 rs766481861	332	T>A		No	ClinGen ExAC gnomAD
CA392824319 rs1285186868	335	N>S		No	ClinGen TOPMed
CA392824359 rs1370836089	337	R>K		No	ClinGen gnomAD
CA392824604 rs1355633113	341	A>V		No	ClinGen TOPMed gnomAD
rs775668590 CA7607927	342	L>R		No	ClinGen ExAC TOPMed gnomAD
rs771290090 CA7607928	344	T>I		No	ClinGen ExAC gnomAD
CA392824703 rs1252962466	349	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA392824702 rs1160811213	349	K>R		No	ClinGen TOPMed
TCGA novel	353	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392824789 rs1596004505	356	S>T		No	ClinGen Ensembl
CA392824807 rs1258301861	359	D>N		No	ClinGen gnomAD
CA7607930 rs759652092	360	N>S		No	ClinGen ExAC gnomAD
rs767562073 CA7607931	361	T>M		No	ClinGen ExAC TOPMed gnomAD
CA272180595 rs767680862	362	A>T		No	ClinGen Ensembl
rs377571348 CA7607932	365	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1417654266 CA392824846	365	R>W		No	ClinGen gnomAD
rs1173198534 CA392824865	368	S>C		No	ClinGen gnomAD
CA392824884 rs949502394	371	A>G		No	ClinGen TOPMed gnomAD
CA392824882 rs1261712905	371	A>T		No	ClinGen TOPMed gnomAD
CA272180599 rs949502394	371	A>V		No	ClinGen TOPMed gnomAD
CA7607935 rs145358886	372	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA7607934 rs763965302	372	E>K		No	ClinGen ExAC gnomAD
rs145312138 CA392824920	376	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750366999 CA7607938	377	I>M		No	ClinGen ExAC gnomAD
rs1310645644 CA392824925	377	I>T		No	ClinGen gnomAD
rs142457516 CA7607939	381	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779708500 CA7607940	382	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA7607941 rs746667073	384	Q>E		No	ClinGen ExAC gnomAD
rs778220146 CA7607943	385	A>V		No	ClinGen ExAC gnomAD
rs1275265731 CA392824983	386	N>D		No	ClinGen TOPMed
rs749570361 CA7607944	386	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1209019485 CA392824992	387	N>H		No	ClinGen gnomAD
CA7607945 rs771292620	387	N>T		No	ClinGen ExAC TOPMed gnomAD
CA392825001 rs1188593213	388	D>G		No	ClinGen gnomAD
CA392825013 TCGA novel rs1596004702	390	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs1428511888 CA392825023	391	L>F		No	ClinGen gnomAD
rs1322131976 CA392825025	391	L>P		No	ClinGen TOPMed
CA7607948 rs772205158	392	L>F		No	ClinGen ExAC gnomAD
rs775479947 CA7607949	392	L>P		No	ClinGen ExAC gnomAD
TCGA novel	395	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760911076 CA7607951	400	I>N		No	ClinGen ExAC TOPMed gnomAD
rs1404648659 CA392825299	400	I>V		No	ClinGen TOPMed
rs768722767 CA7607952	401	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA392825308 rs1426456011	401	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1456278452 CA392825311	402	L>F		No	ClinGen gnomAD
rs1456278452 CA392825310	402	L>I		No	ClinGen gnomAD
rs1434351450 CA392825317	403	L>Q		No	ClinGen gnomAD
CA7607953 rs776881596	406	V>L		No	ClinGen ExAC gnomAD
CA7607954 rs761562391	407	R>C		No	ClinGen ExAC gnomAD
rs370174132 CA7607955	407	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	407	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	407	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567332905 CA392807517	408	A>T		No	ClinGen Ensembl
rs987793234 CA271396024	411	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA392807538 rs987793234	411	D>Y		No	ClinGen gnomAD
CA392807548 rs1469342280	412	Q>R		No	ClinGen gnomAD
CA392807554 rs1187830736	413	R>C		No	ClinGen TOPMed
CA7607974 rs141526583	413	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs762863820 CA271396025	417	W>C		No	ClinGen Ensembl
CA392807630 rs1472148389	417	W>G		No	ClinGen gnomAD
rs1472148389 CA392807628	417	W>R		No	ClinGen gnomAD
CA7607976 rs769483271	419	R>C		No	ClinGen ExAC TOPMed gnomAD
rs769483271 CA392807660	419	R>G		No	ClinGen ExAC TOPMed gnomAD
rs773086930 CA7607977	419	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1596007453 CA392807665	420	W>G		No	ClinGen Ensembl
rs766376885 CA7607979	421	Q>H		No	ClinGen ExAC gnomAD
CA7607978 rs763003400	421	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA392807694 rs1596007481	422	D>G		No	ClinGen Ensembl
CA7607980 rs751507693	422	D>Y		No	ClinGen ExAC
rs759013539 CA7607981	426	T>I		No	ClinGen ExAC
CA392807796 rs1271147187	429	K>R		No	ClinGen TOPMed
rs1197690499 CA392807817	431	R>G		No	ClinGen TOPMed
TCGA novel	431	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs561096025 CA7607982	431	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392807818 rs1197690499	431	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA392807898 rs1350167240	434	E>D		No	ClinGen gnomAD
rs754631936 CA7607984	434	E>K	Variant assessed as Somatic; 4.627e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7607985 rs779262096	435	A>S		No	ClinGen ExAC gnomAD
CA7607986 rs750747617	436	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7607987 rs758734208	440	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7607989 rs200417063	441	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA7607988 rs540354481	441	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7607990 rs768688399	442	K>R		No	ClinGen ExAC gnomAD
CA392808003 rs1472097787	444	D>N		No	ClinGen gnomAD
CA7607991 rs781270180	451	D>N		No	ClinGen ExAC gnomAD
rs781522804 CA7607993	452	E>G		No	ClinGen ExAC gnomAD
rs1017306411 CA271396028	452	E>K		No	ClinGen TOPMed gnomAD
rs781522804 CA271396029	452	E>V		No	ClinGen ExAC gnomAD
rs1411579502 CA392808125	453	I>L		No	ClinGen TOPMed gnomAD
CA7607995 rs749131116	454	L>F		No	ClinGen ExAC gnomAD
CA7607996 rs770823253	454	L>R		No	ClinGen ExAC gnomAD
rs199766690 CA7607997	455	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA7608023 rs549703675	457	E>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7608025 rs768105237	458	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1215454016 COSM1323894 CA392808633	459	R>Q	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs367795170 CA7608026	459	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA392808656 rs1596009583	460	V>G		No	ClinGen Ensembl
rs188673935 CA7608028	462	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7608027 rs371935810	462	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	463	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271396204 rs1021340351	463	Y>H		No	ClinGen gnomAD
CA392808759 rs1596009625	466	D>G		No	ClinGen Ensembl
CA7608030 VAR_034507 rs1802376	466	D>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs76908230 CA392808781	467	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392808786 rs960643308	468	E>K		No	ClinGen TOPMed gnomAD
rs960643308 CA271396205	468	E>Q		No	ClinGen TOPMed gnomAD
CA392808822 rs1418794109	469	R>T		No	ClinGen gnomAD
CA7608034 rs780100137 COSM434136	475	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	477	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746946196 CA7608035	478	V>M		No	ClinGen ExAC gnomAD
rs776064437 CA7608037	480	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs150339032 CA7608036	480	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7608038 rs761479629	482	E>K		No	ClinGen ExAC gnomAD
rs865854439 CA271396247	486	S>F		No	ClinGen Ensembl
rs772488105 CA7608060	488	D>E		No	ClinGen ExAC TOPMed gnomAD
rs762506335 CA7608059	488	D>N		No	ClinGen ExAC TOPMed gnomAD
rs552760571 CA7608062 CA7608061	491	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764654956 CA7608063	492	H>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	493	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1167577685 CA392809305	493	V>L		No	ClinGen TOPMed gnomAD
CA392809301 rs1167577685	493	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7608064 rs376050549	495	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs769222827 CA7608065	496	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs750664045 CA7608067	499	T>I		No	ClinGen ExAC gnomAD
rs1001133436 CA271396249	499	T>S		No	ClinGen Ensembl
CA392809412 rs1297583321	500	L>V		No	ClinGen gnomAD
TCGA novel	501	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1596010338 CA392809507	505	Q>*		No	ClinGen Ensembl
rs779923533 CA7608069	505	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA392809536 rs1191304658	506	Q>R		No	ClinGen TOPMed gnomAD
rs762163011 CA7608083	507	L>P		No	ClinGen ExAC TOPMed gnomAD
rs762163011 CA7608084	507	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA7608085 rs773120118	508	A>S		No	ClinGen ExAC gnomAD
CA392809642 rs1419285805	509	K>*		No	ClinGen gnomAD
CA392809648 rs1161183142	509	K>M		No	ClinGen gnomAD
rs763270451 CA7608086 CA392809650	509	K>N		No	ClinGen ExAC gnomAD
rs766632076 CA7608087	512	E>D		No	ClinGen ExAC gnomAD
CA392809691 rs1567334745	513	A>S		No	ClinGen Ensembl
CA7608089 rs754822161	520	A>T		No	ClinGen ExAC gnomAD
rs1293403254 CA392809771	521	I>T		No	ClinGen TOPMed
CA7608090 rs764229911	522	S>F		No	ClinGen ExAC gnomAD

No associated diseases with Q13596

3 regional properties for Q13596

Type	Name	Position	InterPro Accession
domain	Manganese/iron superoxide dismutase, N-terminal	29 - 115	IPR019831
domain	Manganese/iron superoxide dismutase, C-terminal	125 - 227	IPR019832
binding_site	Manganese/iron superoxide dismutase, binding site	194 - 201	IPR019833

Functions

		Description
EC Number
Subcellular Localization	Endosome membrane ; Peripheral membrane protein; Cytoplasmic side Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side Early endosome membrane; Peripheral membrane protein; Cytoplasmic side Cell projection, lamellipodium	Enriched on tubular elements of the early endosome membrane Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486) Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323) Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558) Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner (PubMed:20604901)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

14 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane	The lipid bilayer surrounding an early endosome.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane	The lipid bilayer surrounding an endosome.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
retromer complex	A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.
retromer, tubulation complex	The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

9 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
epidermal growth factor receptor binding	Binding to an epidermal growth factor receptor.
identical protein binding	Binding to an identical protein or proteins.
insulin receptor binding	Binding to an insulin receptor.
leptin receptor binding	Binding to a leptin receptor.
phosphatidylinositol binding	Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
transferrin receptor binding	Binding to a transferrin receptor.

6 GO annotations of biological process

Name	Definition
early endosome to Golgi transport	The directed movement of substances from early endosomes to the Golgi.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
lamellipodium morphogenesis	A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized.
positive regulation of protein catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
receptor internalization	A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
retrograde transport, endosome to Golgi	The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q05B62	SNX1	Sorting nexin-1	Bos taurus (Bovine)	PR
Q3ZBM5	SNX5	Sorting nexin-5	Bos taurus (Bovine)	PR
O95219	SNX4	Sorting nexin-4	Homo sapiens (Human)	PR
O60749	SNX2	Sorting nexin-2	Homo sapiens (Human)	PR
Q9Y5X3	SNX5	Sorting nexin-5	Homo sapiens (Human)	PR
Q9CWK8	Snx2	Sorting nexin-2	Mus musculus (Mouse)	PR
Q9WV80	Snx1	Sorting nexin-1	Mus musculus (Mouse)	PR
Q99N27	Snx1	Sorting nexin-1	Rattus norvegicus (Rat)	PR
Q9FG38	SNX1	Sorting nexin 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MASGGGGCSA	SERLPPPFPG	LEPESEGAAG	GSEPEAGDSD	TEGEDIFTGA	AVVSKHQSPK
70	80	90	100	110	120
ITTSLLPINN	GSKENGIHEE	QDQEPQDLFA	DATVELSLDS	TQNNQKKVLA	KTLISLPPQE
130	140	150	160	170	180
ATNSSKPQPT	YEELEEEEQE	DQFDLTVGIT	DPEKIGDGMN	AYVAYKVTTQ	TSLPLFRSKQ
190	200	210	220	230	240
FAVKRRFSDF	LGLYEKLSEK	HSQNGFIVPP	PPEKSLIGMT	KVKVGKEDSS	SAEFLEKRRA
250	260	270	280	290	300
ALERYLQRIV	NHPTMLQDPD	VREFLEKEEL	PRAVGTQTLS	GAGLLKMFNK	ATDAVSKMTI
310	320	330	340	350	360
KMNESDIWFE	EKLQEVECEE	QRLRKLHAVV	ETLVNHRKEL	ALNTAQFAKS	LAMLGSSEDN
370	380	390	400	410	420
TALSRALSQL	AEVEEKIEQL	HQEQANNDFF	LLAELLSDYI	RLLAIVRAAF	DQRMKTWQRW
430	440	450	460	470	480
QDAQATLQKK	REAEARLLWA	NKPDKLQQAK	DEILEWESRV	TQYERDFERI	STVVRKEVIR
490	500	510	520
FEKEKSKDFK	NHVIKYLETL	LYSQQQLAKY	WEAFLPEAKA	IS