Q9FG38
Gene name |
SNX1 (VPS5, At5g06140, K16F4.11, MBL20) |
Protein name |
Sorting nexin 1 |
Names |
AtSNX1, Vacuolar protein sorting-associated protein 5 homolog |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G06140 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FG38
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FG38-F1 | Predicted | AlphaFoldDB |
9 variants for Q9FG38
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_1858682_G_A | 24 | P>L | No | 1000Genomes | |
| ENSVATH06929720 | 191 | K>M | No | 1000Genomes | |
| tmp_5_1857095_C_T | 245 | A>T | No | 1000Genomes | |
| tmp_5_1857085_T_A | 248 | D>V | No | 1000Genomes | |
| ENSVATH10603517 | 273 | E>K | No | 1000Genomes | |
| tmp_5_1856672_G_C | 306 | T>R | No | 1000Genomes | |
| ENSVATH06929714 | 322 | D>A | No | 1000Genomes | |
| tmp_5_1856405_T_A | 339 | E>V | No | 1000Genomes | |
| ENSVATH10603482 | 396 | L>F | No | 1000Genomes |
No associated diseases with Q9FG38
5 regional properties for Q9FG38
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phox homology | 141 - 272 | IPR001683 |
| domain | Sorting nexin, N-terminal | 10 - 90 | IPR005329 |
| domain | Sorting nexin/Vps5-like, C-terminal | 286 - 516 | IPR015404 |
| domain | Sorting nexin-1, BAR domain | 286 - 519 | IPR028660 |
| domain | Sorting Nexin 1, PX domain | 145 - 268 | IPR034901 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| multivesicular body | A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| retromer complex | A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin homeostasis | A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. |
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| Golgi to vacuole transport | The directed movement of substances from the Golgi to the vacuole. |
| positive gravitropism | The orientation of plant parts towards gravity. |
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05B62 | SNX1 | Sorting nexin-1 | Bos taurus (Bovine) | PR |
| O95219 | SNX4 | Sorting nexin-4 | Homo sapiens (Human) | PR |
| Q13596 | SNX1 | Sorting nexin-1 | Homo sapiens (Human) | PR |
| O60749 | SNX2 | Sorting nexin-2 | Homo sapiens (Human) | PR |
| Q9CWK8 | Snx2 | Sorting nexin-2 | Mus musculus (Mouse) | PR |
| Q9WV80 | Snx1 | Sorting nexin-1 | Mus musculus (Mouse) | PR |
| Q99N27 | Snx1 | Sorting nexin-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESTEQPRNI | SGSMQSPRSP | SSHPYLSVSV | TDPVKLGNGV | QAYISYRVIT | KTNLPEYQGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKIVIRRYSD | FVWLRDRLFE | KYKGIFIPPL | PEKSAVEKFR | FSAEFIEMRR | AALDIFVNRI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALHPELQQSE | DLRTFLQADE | ETMDRFRFQE | TSIFKKPADL | MQMFRDVQSK | VSDAVLGKEK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVEETTADYE | KLKHYIFELE | NHLTEAQKHA | YRLVKRHREL | GQSLLDFGKA | VKLLGACEGE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PTGKAFSDLG | TKSELLSIKL | QKEAQQVLMN | FEEPLKDYVR | YVQSIKATIA | ERGTAFKQHC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELSETTKLKE | INLDKLMLTR | SDKVGEAEIE | YREIKAESEE | ATRRFERIVK | RMEDEIVRFQ |
| 370 | 380 | 390 | 400 | ||
| EQKTEEMGVA | FHQFAKGQAR | LANSVADAWR | SLLPKLEASY | SV |