Q05B62

PR
Gene name
SNX1
Protein name
Sorting nexin-1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:512029
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05B62

Entry ID Method Resolution Chain Position Source
AF-Q05B62-F1 Predicted AlphaFoldDB

No variants for Q05B62

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05B62

No associated diseases with Q05B62

5 regional properties for Q05B62

Type Name Position InterPro Accession
domain Phox homology 141 - 272 IPR001683
domain Sorting nexin, N-terminal 10 - 90 IPR005329
domain Sorting nexin/Vps5-like, C-terminal 286 - 516 IPR015404
domain Sorting nexin-1, BAR domain 286 - 519 IPR028660
domain Sorting Nexin 1, PX domain 145 - 268 IPR034901

Functions

Description
EC Number
Subcellular Localization
  • Endosome membrane ; Peripheral membrane protein; Cytoplasmic side
  • Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
  • Cell projection, lamellipodium
  • Enriched on tubular elements of the early endosome membrane
  • Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)
  • Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles
  • Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane The lipid bilayer surrounding an early endosome.
endosome membrane The lipid bilayer surrounding an endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
retromer complex A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

4 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
lamellipodium morphogenesis A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized.
receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95219 SNX4 Sorting nexin-4 Homo sapiens (Human) PR
O60749 SNX2 Sorting nexin-2 Homo sapiens (Human) PR
Q13596 SNX1 Sorting nexin-1 Homo sapiens (Human) PR
Q9CWK8 Snx2 Sorting nexin-2 Mus musculus (Mouse) PR
Q9WV80 Snx1 Sorting nexin-1 Mus musculus (Mouse) PR
Q99N27 Snx1 Sorting nexin-1 Rattus norvegicus (Rat) PR
Q9FG38 SNX1 Sorting nexin 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASGGGGCSA SERLPPPFPG LEPESEGAVG GSEPEAGDSD TEGEDIFTGA AAVSKPQSPK
70 80 90 100 110 120
RIASLLPINS GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVPA KTLISLPPQE
130 140 150 160 170 180
ATNSSKPQPS YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPMFRSKH
190 200 210 220 230 240
FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA
250 260 270 280 290 300
ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI
310 320 330 340 350 360
NMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN
370 380 390 400 410 420
TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW
430 440 450 460 470 480
QDAQTTLQKK REAEARLLWA NKPDKLQQAK DEIVEWESRV TQYERDFERI STVVRKEVIR
490 500 510 520
FEKEKSRDFR NHVIQYLETL LHSQQQLAKY WEAFLPEAKA IS