Q9C6Z1

PR
Gene name
NCED5 (At1g30100, T2H7.10)
Protein name
Probable 9-cis-epoxycarotenoid dioxygenase NCED5, chloroplastic
Names
AtNCED5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G30100
EC number
1.13.11.51: With incorporation of two atoms of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C6Z1

Entry ID Method Resolution Chain Position Source
AF-Q9C6Z1-F1 Predicted AlphaFoldDB

57 variants for Q9C6Z1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_10571417_C_T 12 T>I No 1000Genomes
tmp_1_10571422_C_G 14 L>V No 1000Genomes
ENSVATH01127379 20 P>S No 1000Genomes
tmp_1_10571446_G_C 22 D>H No 1000Genomes
ENSVATH01127380 29 S>* No 1000Genomes
tmp_1_10571479_A_T 33 S>C No 1000Genomes
ENSVATH00051172 45 S>C No 1000Genomes
ENSVATH00051172 45 S>F No 1000Genomes
tmp_1_10571536_A_T 52 T>S No 1000Genomes
ENSVATH04671365 55 L>I No 1000Genomes
tmp_1_10571560_A_C 60 N>H No 1000Genomes
ENSVATH14004442 85 A>T No 1000Genomes
ENSVATH00051173 99 R>H No 1000Genomes
tmp_1_10571699_C_T 106 T>I No 1000Genomes
ENSVATH00051174 107 V>L No 1000Genomes
ENSVATH12345866 110 R>C No 1000Genomes
tmp_1_10571711_G_A 110 R>H No 1000Genomes
tmp_1_10571735_C_T 118 A>V No 1000Genomes
ENSVATH00051175 123 Q>K No 1000Genomes
ENSVATH14004443 134 K>R No 1000Genomes
tmp_1_10571795_G_A 138 C>Y No 1000Genomes
ENSVATH01127381 144 L>F No 1000Genomes
tmp_1_10571931_T_A 183 F>L No 1000Genomes
tmp_1_10571992_A_G 204 I>V No 1000Genomes
tmp_1_10572068_A_G 229 N>S No 1000Genomes
ENSVATH12345868 269 E>K No 1000Genomes
tmp_1_10572213_C_G 277 D>E No 1000Genomes
ENSVATH12345869 279 Q>K No 1000Genomes
ENSVATH14004456 296 E>K No 1000Genomes
tmp_1_10572304_C_T 308 P>S No 1000Genomes
ENSVATH04671372 314 K>Q No 1000Genomes
tmp_1_10572331_C_T 317 P>S No 1000Genomes
ENSVATH04671373 335 M>I No 1000Genomes
tmp_1_10572422_T_C 347 I>T No 1000Genomes
tmp_1_10572473_C_T 364 S>F No 1000Genomes
ENSVATH01127383 367 K>N No 1000Genomes
tmp_1_10572616_G_A 412 D>N No 1000Genomes
ENSVATH12345870 424 A>V No 1000Genomes
tmp_1_10572717_T_A 445 N>K No 1000Genomes
ENSVATH00051179 448 T>A No 1000Genomes
ENSVATH00051180 452 T>K No 1000Genomes
tmp_1_10572743_G_A 454 R>K No 1000Genomes
ENSVATH04671375 457 I>V No 1000Genomes
tmp_1_10572817_A_C 479 T>P No 1000Genomes
ENSVATH12345872 516 Y>C No 1000Genomes
ENSVATH14004457 517 G>D No 1000Genomes
ENSVATH04671376 524 P>S No 1000Genomes
tmp_1_10573016_A_G 545 E>G No 1000Genomes
ENSVATH04671377 553 I>F No 1000Genomes
ENSVATH04671377 553 I>L No 1000Genomes
ENSVATH00051182 562 E>K No 1000Genomes
tmp_1_10573067_A_T 562 E>V No 1000Genomes
tmp_1_10573078_A_C 566 K>Q No 1000Genomes
ENSVATH12345874 568 P>L No 1000Genomes
tmp_1_10573093_G_A 571 V>I No 1000Genomes
tmp_1_10573127_C_T 582 S>L No 1000Genomes
tmp_1_10573148_C_A 589 A>D No 1000Genomes

No associated diseases with Q9C6Z1

2 regional properties for Q9C6Z1

Type Name Position InterPro Accession
conserved_site Thymidylate kinase, conserved site 95 - 107 IPR018095
domain Thymidylate kinase-like domain 9 - 200 IPR039430

Functions

Description
EC Number 1.13.11.51 With incorporation of two atoms of oxygen
Subcellular Localization
  • Plastid, chloroplast thylakoid membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.

3 GO annotations of molecular function

Name Definition
9-cis-epoxycarotenoid dioxygenase activity Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al.
carotenoid dioxygenase activity Catalysis of the oxidative cleavage of carotenoids.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid.
carotene catabolic process The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
seed dormancy process A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q28175 RPE65 Retinoid isomerohydrolase Bos taurus (Bovine) PR
Q9YGX2 RPE65 Retinoid isomerohydrolase Gallus gallus (Chicken) PR
Q16518 RPE65 Retinoid isomerohydrolase Homo sapiens (Human) PR
O24592 VP14 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic Zea mays (Maize) PR
Q91ZQ5 Rpe65 Retinoid isomerohydrolase Mus musculus (Mouse) PR
O70276 Rpe65 Retinoid isomerohydrolase Rattus norvegicus (Rat) PR
Q8LIY8 CCD8B Carotenoid cleavage dioxygenase 8 homolog B, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9LRM7 NCED6 9-cis-epoxycarotenoid dioxygenase NCED6, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR7 NCED3 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MACSYILTPN PTKLNLSFAP SDLDAPSPSS SVSFTNTKPR RRKLSANSVS DTPNLLNFPN
70 80 90 100 110 120
YPSPNPIIPE KDTSRWNPLQ RAASAALDFA ETALLRRERS KPLPKTVDPR HQISGNYAPV
130 140 150 160 170 180
PEQSVKSSLS VDGKIPDCID GVYLRNGANP LFEPVSGHHL FDGDGMVHAV KITNGDASYS
190 200 210 220 230 240
CRFTETERLV QEKQLGSPIF PKAIGELHGH SGIARLMLFY ARGLFGLLNH KNGTGVANAG
250 260 270 280 290 300
LVYFHDRLLA MSEDDLPYQV RVTDNGDLET IGRFDFDGQL SSAMIAHPKI DPVTKELFAL
310 320 330 340 350 360
SYDVVKKPYL KYFKFSPEGE KSPDVEIPLA SPTMMHDFAI TENFVVIPDQ QVVFKLSDMF
370 380 390 400 410 420
LGKSPVKYDG EKISRFGILP RNAKDASEMV WVESPETFCF HLWNAWESPE TDEVVVIGSC
430 440 450 460 470 480
MTPADSIFNE CDEQLNSVLS EIRLNLKTGK STRRTIIPGS VQMNLEAGMV NRNLLGRKTR
490 500 510 520 530 540
YAYLAIAEPW PKVSGFAKVD LSTGEVKNHF YGGKKYGGEP FFLPRGLESD GEDDGYIMSF
550 560 570 580
VHDEESWESE LHIVNAVTLE LEATVKLPSR VPYGFHGTFV NSADMLNQA