Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

2 structures for O24592

Entry ID Method Resolution Chain Position Source
3NPE X-ray 320 A A 76-604 PDB
AF-O24592-F1 Predicted AlphaFoldDB

No variants for O24592

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O24592

No associated diseases with O24592

No regional properties for O24592

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O24592

Functions

Description
EC Number 1.13.11.51 With incorporation of two atoms of oxygen
Subcellular Localization
  • Plastid, chloroplast stroma
  • Partially bound to the thylakoid membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.

3 GO annotations of molecular function

Name Definition
9-cis-epoxycarotenoid dioxygenase activity Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al.
carotenoid dioxygenase activity Catalysis of the oxidative cleavage of carotenoids.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid.
carotene catabolic process The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q28175 RPE65 Retinoid isomerohydrolase Bos taurus (Bovine) PR
Q9YGX2 RPE65 Retinoid isomerohydrolase Gallus gallus (Chicken) PR
Q16518 RPE65 Retinoid isomerohydrolase Homo sapiens (Human) PR
Q91ZQ5 Rpe65 Retinoid isomerohydrolase Mus musculus (Mouse) PR
O70276 Rpe65 Retinoid isomerohydrolase Rattus norvegicus (Rat) PR
Q8LIY8 CCD8B Carotenoid cleavage dioxygenase 8 homolog B, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9LRM7 NCED6 9-cis-epoxycarotenoid dioxygenase NCED6, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9C6Z1 NCED5 Probable 9-cis-epoxycarotenoid dioxygenase NCED5, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR7 NCED3 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MQGLAPPTSV SIHRHLPARS RARASNSVRF SPRAVSSVPP AECLQAPFHK PVADLPAPSR
70 80 90 100 110 120
KPAAIAVPGH AAAPRKAEGG KKQLNLFQRA AAAALDAFEE GFVANVLERP HGLPSTADPA
130 140 150 160 170 180
VQIAGNFAPV GERPPVHELP VSGRIPPFID GVYARNGANP CFDPVAGHHL FDGDGMVHAL
190 200 210 220 230 240
RIRNGAAESY ACRFTETARL RQERAIGRPV FPKAIGELHG HSGIARLALF YARAACGLVD
250 260 270 280 290 300
PSAGTGVANA GLVYFNGRLL AMSEDDLPYH VRVADDGDLE TVGRYDFDGQ LGCAMIAHPK
310 320 330 340 350 360
LDPATGELHA LSYDVIKRPY LKYFYFRPDG TKSDDVEIPL EQPTMIHDFA ITENLVVVPD
370 380 390 400 410 420
HQVVFKLQEM LRGGSPVVLD KEKTSRFGVL PKHAADASEM AWVDVPDCFC FHLWNAWEDE
430 440 450 460 470 480
ATGEVVVIGS CMTPADSIFN ESDERLESVL TEIRLDARTG RSTRRAVLPP SQQVNLEVGM
490 500 510 520 530 540
VNRNLLGRET RYAYLAVAEP WPKVSGFAKV DLSTGELTKF EYGEGRFGGE PCFVPMDPAA
550 560 570 580 590 600
AHPRGEDDGY VLTFVHDERA GTSELLVVNA ADMRLEATVQ LPSRVPFGFH GTFITGQELE
AQAA