Q960N3

PR
Gene name
cort
Protein name
Protein cortex
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG11330
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q960N3

Entry ID Method Resolution Chain Position Source
AF-Q960N3-F1 Predicted AlphaFoldDB

No variants for Q960N3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q960N3

No associated diseases with Q960N3

No regional properties for Q960N3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q960N3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
anaphase-promoting complex binding Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
ubiquitin ligase activator activity Binds to and increases the activity of a ubiquitin ligase.

11 GO annotations of biological process

Name Definition
anaphase-promoting complex-dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
cellularization The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
egg activation The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.
female meiosis I The cell cycle process in which the first meiotic division occurs in the female germline.
female meiosis II The cell cycle process in which the second meiotic division occurs in the female germline.
female meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
homologous chromosome segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
pole cell formation Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
positive regulation of anaphase-promoting complex-dependent catabolic process Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.
positive regulation of ubiquitin protein ligase activity Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50082 AMA1 Meiosis-specific APC/C activator protein AMA1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P26309 CDC20 APC/C activator protein CDC20 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9UM11 FZR1 Fizzy-related protein homolog Homo sapiens (Human) PR
Q12834 CDC20 Cell division cycle protein 20 homolog Homo sapiens (Human) PR
Q9R1K5 Fzr1 Fizzy-related protein homolog Mus musculus (Mouse) PR
Q9JJ66 Cdc20 Cell division cycle protein 20 homolog Mus musculus (Mouse) PR
Q62623 Cdc20 Cell division cycle protein 20 homolog Rattus norvegicus (Rat) PR
Q8LPL5 FZR3 Protein FIZZY-RELATED 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MFVEMSVCDS PNKNSKLDKK SLTPFKKVRR KNWKQEAAYK SDTSKGQEVS YVGERFIPNR
70 80 90 100 110 120
FERENIEFNL KYIGKRKERD ILETGVTLTA SYWRQSGFIS NINRTFGIGE RRLFQFSSQQ
130 140 150 160 170 180
GTRSRVVDND SADSDWPCNP RARPYAIQNA THEMPGICSP VDYNMMDWSS GGMVAMSSGQ
190 200 210 220 230 240
DVMLWRNLDE STMVFSVESP TSLKYSPDGK HLAIGCMDRN YPVLDLWEVR SPTEFLVSYR
250 260 270 280 290 300
KLFFKSMGYI SCIEWSHDGK EVICGTQCGV IIVLAMPTLN TLMQLREHRH TVKKMKFAPT
310 320 330 340 350 360
HKYFASSDTD GKIFIFDAVL KVRLLKLDGR SIVFDWHPWT GEDLAVAERS PASIFIFNIP
370 380 390 400 410 420
RRQFVASYRR RDDRIVIKTL TYSKITGELL VNVIRRDDAD LAVCEILVLA SLNRVVDLMS
430 440 450 460 470 480
HQDRGTLFLM WNPDGTKIAT GGLDDTFSLW NFFPTYKREA ILRKQEQKAK DKCSSLSLYK
GIR