Q12834
PR
Gene name |
CDC20 |
Protein name |
Cell division cycle protein 20 homolog |
Names |
p55CDC |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:991 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
12 structures for Q12834
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4GGA | X-ray | 204 A | A | 81-499 | PDB |
| 4GGC | X-ray | 135 A | A | 161-477 | PDB |
| 4GGD | X-ray | 244 A | A/B | 71-499 | PDB |
| 4N14 | X-ray | 210 A | A | 165-477 | PDB |
| 5G04 | EM | 400 A | R | 1-499 | PDB |
| 5KHR | EM | 610 A | R | 1-499 | PDB |
| 5KHU | EM | 480 A | R/S | 1-499 | PDB |
| 5LCW | EM | 400 A | PDB | ||
| 6F0X | EM | 460 A | Q | 1-499 | PDB |
| 6Q6G | EM | 320 A | R | 1-499 | PDB |
| 6Q6H | EM | 320 A | R | 1-499 | PDB |
| AF-Q12834-F1 | Predicted | AlphaFoldDB |
347 variants for Q12834
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs781228317 CA807072 |
2 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA807073 rs747643635 |
4 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA807074 rs769317252 |
6 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs772787630 CA807075 |
7 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA807077 rs772384007 |
10 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1368731242 CA339998583 |
11 | H>Y | No |
ClinGen gnomAD |
|
|
rs1467610586 CA339998651 |
15 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA339998743 rs1175552718 |
17 | D>H | No |
ClinGen TOPMed |
|
|
rs764603179 CA807080 |
20 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA21619356 rs1035759944 |
22 | N>D | No |
ClinGen TOPMed |
|
| TCGA novel | 22 | N>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA807081 rs777078487 |
22 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 24 | P>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA807082 rs761850704 |
25 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs750680898 CA807084 |
25 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs761850704 CA807083 |
25 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1265645939 CA339999020 |
27 | R>H | No |
ClinGen gnomAD |
|
|
CA339999030 rs1257652401 |
28 | W>* | No |
ClinGen TOPMed |
|
|
CA807086 rs758653830 |
29 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA21619366 rs866946379 |
30 | R>C | No |
ClinGen Ensembl |
|
|
rs750044222 CA21619368 |
30 | R>L | No |
ClinGen gnomAD |
|
|
rs1006394021 CA21619370 |
34 | E>K | No |
ClinGen Ensembl |
|
|
CA807087 rs766651928 |
36 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA21619373 rs766651928 |
36 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1188441660 CA339999204 |
37 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA339999280 rs1309255993 |
39 | A>V | No |
ClinGen gnomAD |
|
|
rs754780326 CA807090 |
40 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1457263542 CA339999392 |
43 | M>T | No |
ClinGen gnomAD |
|
|
rs962562704 CA21619384 |
43 | M>V | No |
ClinGen gnomAD |
|
|
CA339999435 rs1286202948 |
45 | A>T | No |
ClinGen TOPMed |
|
|
rs1291596274 CA339999461 |
46 | A>P | No |
ClinGen gnomAD |
|
|
CA339999534 rs1390520006 |
48 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA807092 rs748095701 |
48 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755637225 CA807093 |
50 | H>P | No |
ClinGen ExAC gnomAD |
|
|
CA339999671 rs1336035472 |
51 | S>I | No |
ClinGen TOPMed |
|
|
rs1288187516 CA339999675 |
51 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA339999713 rs1229530921 |
54 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs755753874 CA21619394 |
54 | R>S | No |
ClinGen Ensembl |
|
|
rs1023271328 CA21619397 |
55 | T>A | No |
ClinGen TOPMed |
|
|
CA339999745 rs1221886479 |
55 | T>S | No |
ClinGen gnomAD |
|
|
rs1313035497 CA339999757 |
56 | P>S | No |
ClinGen gnomAD |
|
|
rs148504469 CA807095 |
57 | G>R | No |
ClinGen ESP TOPMed |
|
|
rs766099037 CA807098 |
58 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339999846 rs1484301576 |
60 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA339999979 rs1472817485 |
63 | S>C | No |
ClinGen gnomAD |
|
|
CA339999978 rs1472817485 |
63 | S>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 72 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340000269 rs1338838649 |
76 | G>S | No |
ClinGen TOPMed |
|
|
rs911685120 CA21619460 |
78 | R>P | No |
ClinGen TOPMed |
|
|
CA340000385 rs1391149796 |
84 | S>T | No |
ClinGen TOPMed |
|
|
CA21619463 rs572168835 |
88 | M>I | No |
ClinGen 1000Genomes TOPMed |
|
|
CA340000459 rs1318730890 |
88 | M>V | No |
ClinGen TOPMed |
|
|
rs1165813119 CA340000507 |
89 | E>D | No |
ClinGen gnomAD |
|
|
rs766847817 CA21619466 |
89 | E>K | No |
ClinGen Ensembl |
|
|
CA340000579 rs1432324258 |
92 | S>G | No |
ClinGen gnomAD |
|
|
CA807126 rs773552061 |
92 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA340000593 rs773552061 |
92 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA340000695 rs1286882456 |
95 | L>V | No |
ClinGen gnomAD |
|
|
rs945897493 CA21619472 |
96 | S>N | No |
ClinGen TOPMed |
|
|
rs1370102856 CA340000785 |
97 | K>R | No |
ClinGen gnomAD |
|
|
rs1444745607 CA340000837 |
99 | N>S | No |
ClinGen gnomAD |
|
|
CA340000884 rs1310581648 |
101 | P>A | No |
ClinGen gnomAD |
|
|
rs373153778 CA807128 |
102 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs754596301 CA21619482 |
103 | N>K | No |
ClinGen Ensembl |
|
|
CA340000957 rs1472081242 |
104 | S>G | No |
ClinGen TOPMed |
|
|
rs1275678866 CA340000973 |
104 | S>N | No |
ClinGen gnomAD |
|
|
CA340001013 rs1482863798 |
106 | T>M | No |
ClinGen gnomAD |
|
|
CA807131 rs774771408 |
107 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA340001060 rs1191757473 |
108 | T>I | No |
ClinGen gnomAD |
|
|
rs759825563 CA807132 |
108 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs761745431 CA807156 |
111 | E>* | No |
ClinGen ExAC gnomAD |
|
|
COSM681309 CA807157 rs761745431 |
111 | E>K | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1225329364 CA340001232 |
112 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs749961221 CA807158 |
115 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA807159 rs757864342 |
115 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1272320385 CA340001275 |
116 | W>C | No |
ClinGen gnomAD |
|
|
CA21619568 rs17849349 |
117 | A>V | No |
ClinGen Ensembl |
|
|
CA21619574 rs113848060 |
119 | N>D | No |
ClinGen Ensembl |
|
|
rs757852476 CA340001330 |
124 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA340001332 rs1472941737 |
125 | V>L | No |
ClinGen gnomAD |
|
|
CA21619587 rs955308856 |
126 | E>D | No |
ClinGen Ensembl |
|
| TCGA novel | 126 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745973446 CA807167 |
127 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1272542089 CA340001372 |
131 | L>F | No |
ClinGen TOPMed |
|
|
CA340001389 rs1227989386 |
134 | S>R | No |
ClinGen TOPMed |
|
|
CA807171 rs747181936 |
135 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs768859460 CA807172 |
137 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA807173 rs141215457 |
138 | Q>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs761551175 CA807174 |
140 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA807175 rs144561572 |
140 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs146697135 CA807178 |
142 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs146697135 CA21619598 |
142 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1203272663 CA340001550 |
143 | G>C | No |
ClinGen gnomAD |
|
|
rs974784687 CA21619735 |
144 | Y>N | No |
ClinGen TOPMed |
|
|
CA21619740 rs946396248 |
145 | Q>R | No |
ClinGen TOPMed |
|
|
rs1306925757 CA340001795 |
150 | V>I | No |
ClinGen TOPMed |
|
| TCGA novel | 152 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1325492757 CA340001902 |
153 | S>N | No |
ClinGen gnomAD |
|
|
rs1331587384 CA340002016 |
156 | A>P | No |
ClinGen gnomAD |
|
|
rs1229392616 CA340002028 |
156 | A>V | No |
ClinGen TOPMed |
|
|
CA807204 rs201827674 |
157 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA807206 rs755057851 |
161 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340002234 rs1228757840 |
161 | S>R | No |
ClinGen gnomAD |
|
|
CA807207 rs781443151 |
162 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA807209 rs200111540 |
162 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA807208 rs781443151 |
162 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777550029 CA807210 CA340002323 |
163 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1570481353 CA340002289 |
163 | K>Q | No |
ClinGen Ensembl |
|
|
rs1570481359 CA340002299 |
163 | K>T | No |
ClinGen Ensembl |
|
|
CA807212 rs200928542 |
164 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs1319447458 CA340002350 |
165 | C>R | No |
ClinGen gnomAD |
|
|
rs774304982 CA807213 |
166 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340002512 rs1450155087 |
168 | I>V | No |
ClinGen gnomAD |
|
|
rs771681686 CA807215 |
169 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA807217 rs760396935 |
173 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1444032610 CA340002679 |
173 | D>G | No |
ClinGen TOPMed |
|
|
CA807216 rs372598188 |
173 | D>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340002750 rs1164813067 |
174 | R>H | No |
ClinGen gnomAD |
|
|
rs750779037 CA340002904 |
178 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763769478 CA807218 |
178 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs750779037 CA807219 |
178 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766839844 CA807221 |
180 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs752085108 CA807222 |
182 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs755109406 CA807223 |
183 | N>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 185 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1474784752 CA340003549 |
186 | Y>* | No |
ClinGen gnomAD |
|
| TCGA novel | 187 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs752794876 CA807243 |
188 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1419610130 CA340003643 |
189 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs202067829 CA21619881 |
189 | L>R | No |
ClinGen Ensembl |
|
|
rs764261591 CA807245 |
193 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1467130660 CA340004141 |
198 | L>V | No |
ClinGen gnomAD |
|
|
CA340004168 rs1313155974 |
199 | A>V | No |
ClinGen gnomAD |
|
|
CA340004212 rs1290632615 |
201 | A>E | No |
ClinGen gnomAD |
|
|
rs758421116 CA807251 |
204 | N>D | No |
ClinGen ExAC TOPMed |
|
|
CA807252 rs780101568 |
204 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768263875 CA807254 |
205 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA21622013 rs1008710834 |
210 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA340006161 rs1253728250 |
211 | A>E | No |
ClinGen gnomAD |
|
|
rs769264787 CA807257 |
212 | S>N | No |
ClinGen ExAC |
|
|
rs1470384075 CA340006223 |
215 | D>E | No |
ClinGen gnomAD |
|
|
CA21622031 rs1018801511 |
215 | D>N | No |
ClinGen TOPMed |
|
|
rs1176619285 CA340006236 |
216 | I>T | No |
ClinGen gnomAD |
|
| TCGA novel | 217 | L>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA807258 rs774793275 |
220 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA21622035 rs928539190 |
222 | M>V | No |
ClinGen Ensembl |
|
|
CA807260 rs759844021 |
225 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA340006384 rs1434451593 |
225 | P>T | No |
ClinGen gnomAD |
|
|
CA340006406 rs768042619 |
226 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA807261 rs768042619 |
226 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1309903090 CA340006411 |
227 | E>Q | No |
ClinGen TOPMed |
|
|
rs1309457938 CA340006422 |
228 | Y>C | No |
ClinGen gnomAD |
|
|
rs775943973 CA807262 |
228 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs959898654 CA21622047 |
229 | I>V | No |
ClinGen Ensembl |
|
|
rs1355546057 CA340006449 |
230 | S>F | No |
ClinGen gnomAD |
|
|
rs1297007617 CA340006467 |
231 | S>F | No |
ClinGen gnomAD |
|
|
rs1372731857 CA340006506 |
234 | W>* | No |
ClinGen TOPMed |
|
|
CA807263 rs760792702 |
235 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs764216014 CA807264 |
237 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 238 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA807265 rs754070636 |
238 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs974498501 CA21622065 |
240 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA807267 rs558607093 |
245 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1203532703 CA340006689 |
245 | T>N | No |
ClinGen gnomAD |
|
|
CA340006725 rs1230917271 |
247 | S>N | No |
ClinGen gnomAD |
|
|
rs750276865 CA807268 |
247 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA340006765 rs1557473674 |
249 | E>D | No |
ClinGen Ensembl |
|
|
rs1273751391 CA340006780 |
250 | V>A | No |
ClinGen gnomAD |
|
|
rs916015486 CA21622073 |
251 | Q>* | No |
ClinGen Ensembl |
|
| TCGA novel | 253 | W>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1459241811 TCGA novel CA340006862 |
253 | W>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen TOPMed gnomAD NCI-TCGA |
| TCGA novel | 254 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1262081199 CA340006895 |
255 | V>M | No |
ClinGen TOPMed |
|
|
CA340006932 rs1209133790 |
257 | Q>* | No |
ClinGen TOPMed |
|
| TCGA novel | 259 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs766272694 CA807288 |
260 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1428906188 CA340006979 |
260 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs754957702 CA807290 |
262 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1238221197 CA340007042 |
264 | M>I | No |
ClinGen TOPMed |
|
| TCGA novel | 264 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340007049 rs1570481963 |
265 | T>P | No |
ClinGen Ensembl |
|
|
rs780944056 CA807292 |
266 | S>R | No |
ClinGen ExAC |
|
|
COSM535135 CA807295 rs755545971 |
268 | S>F | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA807294 rs752281358 |
268 | S>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA807296 rs562509738 |
269 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA807297 rs748924941 |
270 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1039194610 CA21622164 |
270 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA340007190 rs1336259710 COSM909757 |
276 | W>* | endometrium [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA340007187 rs1187709094 |
276 | W>G | No |
ClinGen gnomAD |
|
|
rs545665041 CA807300 |
277 | N>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA340007229 rs1473861847 |
278 | S>N | No |
ClinGen gnomAD |
|
|
rs190674570 CA807301 |
279 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1011295342 CA21622175 |
281 | L>P | No |
ClinGen TOPMed |
|
|
rs151010435 CA807304 |
282 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143180781 CA807305 |
282 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1292450549 CA340007313 |
283 | S>N | No |
ClinGen gnomAD |
|
|
CA807321 rs781752713 |
284 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1453863337 CA340007388 |
284 | G>S | No |
ClinGen gnomAD |
|
|
CA21622236 rs991296026 |
286 | R>C | No |
ClinGen Ensembl |
|
|
rs1236373882 COSM1289260 CA340007417 |
286 | R>H | oesophagus [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1392234522 CA340007447 |
288 | G>V | No |
ClinGen gnomAD |
|
|
CA340007466 rs1462647269 |
289 | H>Q | No |
ClinGen gnomAD |
|
|
rs748600009 CA807322 |
291 | H>D | No |
ClinGen ExAC gnomAD |
|
|
CA807323 rs549920906 |
292 | H>D | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
rs915711344 CA21622256 |
292 | H>Q | No |
ClinGen TOPMed |
|
|
CA807324 rs549920906 |
292 | H>Y | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
CA340007534 rs1422279845 |
293 | H>R | No |
ClinGen TOPMed |
|
|
rs749335066 CA807325 |
295 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1352704478 CA340007582 |
296 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA340007579 rs112630800 |
296 | R>W | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1371181265 CA340007635 |
299 | E>D | No |
ClinGen gnomAD |
|
|
CA340007647 rs1570482221 |
300 | H>P | No |
ClinGen Ensembl |
|
|
CA340007670 rs1439491994 |
301 | H>R | No |
ClinGen gnomAD |
|
|
CA807327 rs774403959 |
302 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA807328 rs759422114 |
303 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767199661 CA807329 |
311 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA340007850 rs1570482250 |
312 | V>G | No |
ClinGen Ensembl |
|
|
rs775560252 CA807330 |
312 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs760534440 CA807331 |
313 | C>S | No |
ClinGen ExAC gnomAD |
|
|
COSM909758 rs763960946 CA807332 |
316 | R>C | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA807333 rs753367774 |
316 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340007909 rs753367774 |
316 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA21622274 rs867593106 |
318 | A>T | No |
ClinGen Ensembl |
|
|
rs1468134484 CA340007928 |
319 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1468134484 CA340007927 |
319 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA807334 rs756714014 |
321 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs372597302 CA807335 |
322 | R>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA807336 rs140305765 COSM1185439 |
322 | R>Q | lung [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA807337 rs755438046 |
323 | H>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 324 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340008010 rs1372348894 |
325 | A>T | No |
ClinGen gnomAD |
|
| TCGA novel | 325 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340008044 rs1557474018 |
327 | G>S | No |
ClinGen Ensembl |
|
|
CA807339 rs748491001 |
332 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs756714435 CA807340 |
333 | V>I | No |
ClinGen ExAC |
|
|
rs1291108935 CA340008189 |
334 | N>S | No |
ClinGen TOPMed |
|
|
rs1460820886 CA340008241 |
337 | P>S | No |
ClinGen gnomAD |
|
|
rs199542353 CA807341 |
338 | S>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1363373189 CA340008283 |
339 | A>V | No |
ClinGen gnomAD |
|
|
rs749421572 CA807342 |
340 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA807343 rs749421572 |
340 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA21622307 rs200047932 |
343 | G>D | No |
ClinGen gnomAD |
|
|
rs1570482360 CA340008399 |
346 | V>G | No |
ClinGen Ensembl |
|
|
CA340008444 rs1570482374 |
352 | T>P | No |
ClinGen Ensembl |
|
|
rs370835580 CA807346 |
353 | Q>P | No |
ClinGen ESP ExAC gnomAD |
|
|
rs370835580 CA340008453 |
353 | Q>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA807365 rs1801456 RCV000950050 |
361 | V>I | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1801456 CA807366 |
361 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA340008565 rs1412642638 |
363 | W>* | No |
ClinGen TOPMed |
|
|
rs1412642638 CA340008569 |
363 | W>C | No |
ClinGen TOPMed |
|
|
rs1436218002 CA340008582 |
364 | C>* | No |
ClinGen gnomAD |
|
|
CA807367 rs776617856 |
364 | C>G | No |
ClinGen ExAC |
|
|
rs1313097986 CA340008585 |
365 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs761743390 CA807368 |
365 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1313097986 CA340008588 |
365 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA807370 rs368676792 |
369 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs11555249 CA340008686 |
375 | G>A | No |
ClinGen gnomAD |
|
|
rs11555249 CA21622456 |
375 | G>E | No |
ClinGen gnomAD |
|
|
rs1447450639 CA340008682 |
375 | G>R | No |
ClinGen gnomAD |
|
| TCGA novel | 376 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 377 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs761176631 CA807375 |
380 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs764546476 COSM1200339 CA807376 |
380 | R>Q | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs754185453 CA807377 |
383 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs879241526 CA21622474 |
383 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs757848486 CA807378 |
385 | W>C | No |
ClinGen ExAC gnomAD |
|
|
CA340008764 rs1323190702 |
386 | N>S | No |
ClinGen TOPMed |
|
|
CA807379 rs779426473 |
391 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs143739422 CA807381 |
394 | S>G | No |
ClinGen ESP ExAC TOPMed |
|
|
rs1172992921 CA340008879 |
396 | V>G | No |
ClinGen TOPMed gnomAD |
|
|
rs376655758 CA21622488 |
396 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376655758 CA807383 |
396 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1469109526 CA340008890 |
397 | D>E | No |
ClinGen TOPMed |
|
|
rs1319743846 CA340008908 |
399 | H>D | No |
ClinGen gnomAD |
|
|
rs1461973885 CA340008916 |
399 | H>L | No |
ClinGen gnomAD |
|
|
VAR_030368 rs45443196 CA807408 |
402 | V>M | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA340009087 rs1178328048 |
405 | I>N | No |
ClinGen TOPMed gnomAD |
|
|
CA807411 rs745320429 |
413 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs774006843 CA807410 |
413 | E>Q | No |
ClinGen ExAC |
|
|
CA807412 rs771468303 |
414 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340009200 rs771468303 |
414 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762132307 CA807414 |
420 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs201154230 CA21622903 |
421 | A>V | No |
ClinGen 1000Genomes |
|
|
rs773384058 CA807416 |
422 | Q>E | No |
ClinGen ExAC |
|
|
rs1253080127 CA340009445 |
427 | I>S | No |
ClinGen TOPMed gnomAD |
|
|
CA340009449 rs1253080127 |
427 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA340009485 rs1164817256 |
429 | K>E | No |
ClinGen gnomAD |
|
|
CA21622909 rs11555250 CA807417 |
429 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340009534 rs1422493454 |
431 | P>S | No |
ClinGen gnomAD |
|
|
CA807418 rs766822161 |
432 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA340009564 rs1319289274 |
432 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA340009677 rs1222189741 |
438 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA340011393 rs1344375624 |
439 | L>R | No |
ClinGen TOPMed |
|
|
rs751670358 CA807419 |
440 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1183146342 CA340011519 |
443 | T>I | No |
ClinGen gnomAD |
|
| TCGA novel | 445 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA807450 rs779630788 |
448 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1387711470 CA340011545 |
448 | S>N | No |
ClinGen TOPMed |
|
|
rs983182236 CA21623213 |
449 | L>M | No |
ClinGen TOPMed gnomAD |
|
|
CA807451 rs746457353 |
449 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768386993 CA807452 |
450 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA807454 rs150849773 |
451 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760038301 CA807457 |
457 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs772507044 CA807458 |
458 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA807460 rs760628470 |
461 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764416148 CA807461 |
464 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 465 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA340011661 rs1254645412 |
467 | L>M | No |
ClinGen gnomAD |
|
|
rs761756771 CA807465 COSM1736946 |
471 | R>C | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA807466 rs761756771 |
471 | R>G | No |
ClinGen ExAC gnomAD |
|
|
COSM1321061 CA807467 rs750186760 |
471 | R>H | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA807468 rs528069998 |
473 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1193576544 CA340011700 |
473 | F>S | No |
ClinGen TOPMed |
|
|
rs779815758 CA807469 |
475 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA340011715 rs1432832386 |
475 | L>S | No |
ClinGen gnomAD |
|
|
rs1432832386 CA340011714 |
475 | L>W | No |
ClinGen gnomAD |
|
|
CA340011721 rs1570484441 |
476 | D>A | No |
ClinGen Ensembl |
|
|
rs751120712 CA807470 |
476 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1375787980 CA340011720 |
476 | D>Y | No |
ClinGen gnomAD |
|
|
CA340011727 rs1430272133 |
477 | P>S | No |
ClinGen TOPMed |
|
|
rs200349485 CA340011734 |
478 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA807471 rs200349485 |
478 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs45461499 CA807474 |
479 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs45461499 CA807475 VAR_030369 |
479 | R>Q | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA807473 rs747796157 |
479 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA807477 rs550872587 |
480 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA807476 rs746179756 |
480 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759288917 CA340011742 |
481 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759288917 COSM188742 CA807479 |
481 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA807478 rs775826244 |
481 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA807484 rs142588666 |
483 | R>P | No |
ClinGen ESP ExAC TOPMed |
|
|
CA807483 rs142588666 |
483 | R>Q | No |
ClinGen ESP ExAC TOPMed |
|
|
CA807481 rs377329238 |
483 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370248113 CA807486 |
484 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340011762 rs1488196803 |
485 | K>E | No |
ClinGen gnomAD |
|
|
rs902070557 CA21623355 |
485 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA340011764 rs902070557 |
485 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
CA21623357 rs1045022120 |
486 | A>V | No |
ClinGen Ensembl |
|
|
CA807489 rs751442023 |
487 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374615123 CA807491 |
487 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA340011804 rs1476810160 |
491 | S>I | No |
ClinGen gnomAD |
|
|
rs376581777 CA21623388 |
493 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376581777 CA807493 |
493 | L>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs777360367 CA807494 |
494 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA340011820 rs1450118185 |
494 | I>V | No |
ClinGen TOPMed |
|
|
rs1386723196 CA340011825 |
495 | H>N | No |
ClinGen gnomAD |
|
|
CA807495 rs371111819 |
499 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA |
No associated diseases with Q12834
7 regional properties for Q12834
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 169 - 210 | IPR001680-1 |
| repeat | WD40 repeat | 215 - 294 | IPR001680-2 |
| repeat | WD40 repeat | 298 - 337 | IPR001680-3 |
| repeat | WD40 repeat | 344 - 386 | IPR001680-4 |
| repeat | WD40 repeat | 389 - 429 | IPR001680-5 |
| repeat | WD40 repeat | 432 - 471 | IPR001680-6 |
| domain | Anaphase-promoting complex subunit 4-like, WD40 domain | 223 - 278 | IPR024977 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| anaphase-promoting complex | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitotic checkpoint complex | A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| anaphase-promoting complex binding | Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| histone deacetylase binding | Binding to histone deacetylase. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| ubiquitin ligase activator activity | Binds to and increases the activity of a ubiquitin ligase. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| anaphase-promoting complex-dependent catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
| mitotic spindle assembly checkpoint signaling | A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| negative regulation of ubiquitin-protein transferase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| positive regulation of anaphase-promoting complex-dependent catabolic process | Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of synapse maturation | Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. |
| positive regulation of synaptic plasticity | A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. |
| positive regulation of ubiquitin protein ligase activity | Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of dendrite development | Any process that modulates the frequency, rate or extent of dendrite development. |
| regulation of meiotic cell cycle | Any process that modulates the rate or extent of progression through the meiotic cell cycle. |
| regulation of meiotic nuclear division | Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. |
| regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P50082 | AMA1 | Meiosis-specific APC/C activator protein AMA1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P26309 | CDC20 | APC/C activator protein CDC20 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q960N3 | cort | Protein cortex | Drosophila melanogaster (Fruit fly) | PR |
| Q9UM11 | FZR1 | Fizzy-related protein homolog | Homo sapiens (Human) | PR |
| Q9R1K5 | Fzr1 | Fizzy-related protein homolog | Mus musculus (Mouse) | PR |
| Q9JJ66 | Cdc20 | Cell division cycle protein 20 homolog | Mus musculus (Mouse) | PR |
| Q62623 | Cdc20 | Cell division cycle protein 20 homolog | Rattus norvegicus (Rat) | PR |
| Q8LPL5 | FZR3 | Protein FIZZY-RELATED 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQFAFESDL | HSLLQLDAPI | PNAPPARWQR | KAKEAAGPAP | SPMRAANRSH | SAGRTPGRTP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GKSSSKVQTT | PSKPGGDRYI | PHRSAAQMEV | ASFLLSKENQ | PENSQTPTKK | EHQKAWALNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NGFDVEEAKI | LRLSGKPQNA | PEGYQNRLKV | LYSQKATPGS | SRKTCRYIPS | LPDRILDAPE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IRNDYYLNLV | DWSSGNVLAV | ALDNSVYLWS | ASSGDILQLL | QMEQPGEYIS | SVAWIKEGNY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAVGTSSAEV | QLWDVQQQKR | LRNMTSHSAR | VGSLSWNSYI | LSSGSRSGHI | HHHDVRVAEH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HVATLSGHSQ | EVCGLRWAPD | GRHLASGGND | NLVNVWPSAP | GEGGWVPLQT | FTQHQGAVKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAWCPWQSNV | LATGGGTSDR | HIRIWNVCSG | ACLSAVDAHS | QVCSILWSPH | YKELISGHGF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AQNQLVIWKY | PTMAKVAELK | GHTSRVLSLT | MSPDGATVAS | AAADETLRLW | RCFELDPARR |
| 490 | |||||
| REREKASAAK | SSLIHQGIR |