P26309
PR
Gene name |
CDC20 (YGL116W) |
Protein name |
APC/C activator protein CDC20 |
Names |
Cell division control protein 20 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL116W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P26309
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P26309-F1 | Predicted | AlphaFoldDB |
8 variants for P26309
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-289815 | 2 | P>S | No | SGRP | |
| s07-290011 | 67 | A>G | No | SGRP | |
| s07-290100 | 97 | A>T | No | SGRP | |
| s07-290155 | 115 | I>T | No | SGRP | |
| s07-290165 | 118 | E>D | No | SGRP | |
| s07-290563 | 251 | R>K | No | SGRP | |
| s07-290776 | 322 | D>V | No | SGRP | |
| s07-291091 | 427 | T>S | No | SGRP |
No associated diseases with P26309
No regional properties for P26309
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P26309 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anaphase-promoting complex | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitotic checkpoint complex | A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. |
| mitotic checkpoint complex, CDC20-MAD2 subcomplex | A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20. |
| nuclear periphery | The portion of the nuclear lumen proximal to the inner nuclear membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| anaphase-promoting complex binding | Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. |
| ubiquitin ligase activator activity | Binds to and increases the activity of a ubiquitin ligase. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| anaphase-promoting complex-dependent catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| mitotic spindle assembly checkpoint signaling | A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| negative regulation of ubiquitin-protein transferase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. |
| positive regulation of anaphase-promoting complex-dependent catabolic process | Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. |
| positive regulation of mitotic metaphase/anaphase transition | Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
| positive regulation of ubiquitin protein ligase activity | Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of meiotic nuclear division | Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. |
| regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P50082 | AMA1 | Meiosis-specific APC/C activator protein AMA1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q960N3 | cort | Protein cortex | Drosophila melanogaster (Fruit fly) | PR |
| Q12834 | CDC20 | Cell division cycle protein 20 homolog | Homo sapiens (Human) | PR |
| Q9JJ66 | Cdc20 | Cell division cycle protein 20 homolog | Mus musculus (Mouse) | PR |
| Q62623 | Cdc20 | Cell division cycle protein 20 homolog | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPESSRDKGN | AAISGNRSVL | SIASPTKLNI | LSSDWSRNQG | KVSKNSLKRS | SSLNIRNSKR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSLQASANSI | YSRPKITIGA | PPLIRRDSSF | FKDEFDAKKD | KATFSAYSSR | SYPTIGSESV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSQTSLSQPT | TSREVDEQFT | VAADRYIPIL | QGASQNKVDP | ETLHEALPPP | NASPISHLRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QTKIVFKQNV | AEACGLDMNK | RILQYMPEPP | KCSSLRQKSY | IMKKRTHYSY | QQEQKIPDLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLRKINTNPE | RILDAPGFQD | DFYLNLLSWS | KKNVLAIALD | TALYLWNATT | GDVSLLTDFE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NTTICSVTWS | DDDCHISIGK | EDGNTEIWDV | ETMSLIRTMR | SGLGVRIGSL | SWLDTLIATG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SRSGEIQIND | VRIKQHIVST | WAEHTGEVCG | LSYKSDGLQL | ASGGNDNTVM | IWDTRTSLPQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSKKTHTAAV | KALSWCPYSP | NILASGGGQT | DKHIHFWNSI | TGARVGSINT | GSQVSSLHWG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QSHTSTNGGM | MNKEIVATGG | NPENAISVYN | YETKFKVAEV | VHAHEARICC | SQLSPDGTTL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ATVGGDENLK | FYKIFDPRCT | GRSREDGLMD | GMLGLIGKEG | CRTNDKENRS | KNSSEIHTRR |
| PSSTSQYLIR |