Q95TN4
Gene name |
Cog4 |
Protein name |
Conserved oligomeric Golgi complex subunit 4 |
Names |
COG complex subunit 4, Component of oligomeric Golgi complex 4 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG7456 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q95TN4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q95TN4-F1 | Predicted | AlphaFoldDB |
No variants for Q95TN4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q95TN4 | |||||
No associated diseases with Q95TN4
1 regional properties for Q95TN4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Conserved oligomeric Golgi complex, subunit 4 | 166 - 497 | IPR013167 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi transport complex | A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| Golgi vesicle prefusion complex stabilization | The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06096 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3MHG0 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Bos taurus (Bovine) | PR |
| Q9H9E3 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Homo sapiens (Human) | PR |
| Q8R1U1 | Cog4 | Conserved oligomeric Golgi complex subunit 4 | Mus musculus (Mouse) | PR |
| Q8L838 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVLEQLGAL | DIGTNEQVDE | TLQRIADEEA | KVNEKLESLL | AKQCQIEAKM | SGIGRSLSLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HTVDSDSNKL | NDQIVNTAQL | AESVSAKVRR | LDLARCRASE | CQQRVHDLID | LHLCSQGVVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIGEEDYEKS | ATHIARFLAM | DQQLLRRTAD | DVQGSITSVS | DAVKTLEDAT | EKTRVLIAKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FDEAVKADDL | ASVERFFKIF | PLVGCHRTGI | EKFSLYICQK | LANKAQKELR | NAQDIAKAES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLQLAYADRL | TAILENFARV | VEVNQPIIEA | FYGQASSSLI | DMVSILQHEC | DTEVKNLLME |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FNKNRQIQYR | SKQVNESTQR | SAGGGNLGSN | SIQALGHYRK | PSGGSVDKLN | PKEIDAIIAE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITVMHARVEL | YFRFMRRRLQ | VHVETCVPEK | EQFDIMERYE | KIMKNSDLRR | QMQEILSTYL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLERYFMEES | VLKAIGLDTY | ESGQQCSSMV | DDVFFILRKS | IRRALTTQSI | NGTCAVINNV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AACLDGDFVN | ALKAPLKSGY | PSGYIDLAQA | YNAIQTSLQQ | GKLHSSDADR | GRANFLVQLN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NADISTEYIE | TLCQTMEQEI | AGTFPQTTQV | ERQMLDSCLT | ELKAVRDALK | ATVDFGMQQL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RSSVIKPRLN | PWINQFLNYS | HNLNEEELAA | YEAGETFVQF | FIVQLDGLLN | SFKNSLSPRN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YDALVSILAT | EVTIQLERAI | KKISFNRLGG | LVLDQEVRAL | GSYLTGATSW | SVRDKMTRIS |
| 730 | 740 | 750 | 760 | 770 | |
| QIATLLNLDK | ITELSEYWNP | ENNKEMSSWH | LTPNEVRTFL | TLRNDFRIED | IKRLQL |