Q8R1U1
Gene name |
Cog4 |
Protein name |
Conserved oligomeric Golgi complex subunit 4 |
Names |
COG complex subunit 4, Component of oligomeric Golgi complex 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:102339 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R1U1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R1U1-F1 | Predicted | AlphaFoldDB |
34 variants for Q8R1U1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389012896 | 63 | L>P | No | EVA | |
| rs3389014096 | 66 | Q>* | No | EVA | |
| rs3389008861 | 79 | R>M | No | EVA | |
| rs3389012922 | 123 | Y>* | No | EVA | |
| rs3389013117 | 141 | G>E | No | EVA | |
| rs3389005112 | 155 | A>T | No | EVA | |
| rs3399598708 | 164 | L>Q | No | EVA | |
| rs3389013088 | 171 | L>F | No | EVA | |
| rs3388988197 | 249 | E>K | No | EVA | |
| rs3389014016 | 273 | T>I | No | EVA | |
| rs3388980318 | 317 | V>I | No | EVA | |
| rs3388999197 | 344 | T>A | No | EVA | |
| rs3388980320 | 357 | T>I | No | EVA | |
| rs3389016985 | 385 | D>H | No | EVA | |
| rs3389005200 | 403 | L>F | No | EVA | |
| rs3389005173 | 411 | C>Y | No | EVA | |
| rs3388988140 | 447 | T>S | No | EVA | |
| rs3388992025 | 449 | S>I | No | EVA | |
| rs3388999271 | 475 | C>S | No | EVA | |
| rs3389016907 | 513 | V>E | No | EVA | |
| rs3389005186 | 522 | S>I | No | EVA | |
| rs3389016975 | 535 | E>K | No | EVA | |
| rs3388999262 | 558 | I>M | No | EVA | |
| rs3389012905 | 581 | Q>* | No | EVA | |
| rs3388988126 | 595 | A>V | No | EVA | |
| rs248090013 | 609 | A>T | No | EVA | |
| rs3388980269 | 630 | V>F | No | EVA | |
| rs3389016949 | 668 | S>F | No | EVA | |
| rs3388988181 | 707 | E>K | No | EVA | |
| rs3389017772 | 754 | G>S | No | EVA | |
| rs3389006075 | 763 | A>D | No | EVA | |
| rs3388999247 | 764 | E>Q | No | EVA | |
| rs3389010796 | 778 | E>D | No | EVA | |
| rs3389017840 | 784 | R>G | No | EVA |
No associated diseases with Q8R1U1
1 regional properties for Q8R1U1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Conserved oligomeric Golgi complex, subunit 4 | 188 - 498 | IPR013167 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi transport complex | A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| glycosylation | The covalent attachment and further modification of carbohydrate residues to a substrate molecule. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| Golgi vesicle prefusion complex stabilization | The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| retrograde transport, vesicle recycling within Golgi | The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06096 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3MHG0 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Bos taurus (Bovine) | PR |
| Q95TN4 | Cog4 | Conserved oligomeric Golgi complex subunit 4 | Drosophila melanogaster (Fruit fly) | PR |
| Q9H9E3 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Homo sapiens (Human) | PR |
| Q8L838 | COG4 | Conserved oligomeric Golgi complex subunit 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEVESPLKL | SGAPPPPEGV | GGGHCSEIST | ELIRSLTELQ | ELEAVYERLC | GEEKAVEKEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DALLEQQNTI | ESKMVTLHRM | GPSLQLIEGD | AKQLAGMITF | TCSLAENVSS | KVRQLDLAKN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLYQAIQRAD | DILDLKFCMD | GVQTALRNED | YEQAAAHIHR | YLCLDKSVIE | LSRQGKEGSM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDANLKLLQE | AEQRLKAIVA | EKFAIATKEG | DLPQVERFFK | IFPLLGLHED | GLSKFSEYLC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KQVASKAEEN | LLLVLGSDMS | DRRAAVIFAD | TLTLLFEGIA | RIVETHQPIV | ETYYGPGRLF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLIKYLQVEC | DTQVEKVVNK | FIKQRDYHQQ | FRLVQSNLMR | NSATEKIEPR | ELDPVLTEVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LMNARSELYL | RFLRKRISAD | FEVGDSMASE | EVKQEHQKCL | DKLLNNCLLS | CTMQELIGFY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ITMEEYFMRE | TVNKAVALDT | YEKGQLTSSM | VDDVFYIVKK | CIGRALSSSN | IDCLCAMINL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ATRELEADFR | DVLCNKLRMG | FPATTLQDIQ | RGVTSAVNIM | HSSLQQGKFD | TKGIESTDEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLSFLVTLNN | VEVCSENIST | LKKTLESDCT | KLFSQGIGGE | QAQAKFDSCL | SDLAAVSNKF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RDLLQEGLAE | LNSSAVKPQV | QPWINTFLSV | SHSIEEEEFN | DYEANDPWVQ | QFILNLEQQM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AEFKASLSPV | IYDSLTGLMT | SLVAVELEKV | VLKSTFNRLG | GLQFDKELRS | LIAYLTTVTT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WTIRDKFARL | SQMATILNLE | RVTEILDYWG | ANSGPLTWRL | TPAEVRQVLA | LRIDFRNEDI |
| KRLRL |