Q3MHG0

PR
Gene name
COG4
Protein name
Conserved oligomeric Golgi complex subunit 4
Names
COG complex subunit 4, Component of oligomeric Golgi complex 4
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533007
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3MHG0

Entry ID Method Resolution Chain Position Source
AF-Q3MHG0-F1 Predicted AlphaFoldDB

130 variants for Q3MHG0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453770647 3 D>A No EVA
rs442662458 9 K>Q No EVA
rs452360901 11 S>* No EVA
rs461118174 11 S>A No EVA
rs452360901 11 S>L No EVA
rs458844265 12 G>S No EVA
rs477479654 14 P>A No EVA
rs470819750 14 P>H No EVA
rs477479654 14 P>T No EVA
rs459801941 16 P>A No EVA
rs459801941 16 P>S No EVA
rs481292041 17 P>H No EVA
rs481292041 17 P>R No EVA
rs482214602 18 D>A No EVA
rs470168816 18 D>N No EVA
rs446355312 20 V>A No EVA
rs446355312 20 V>G No EVA
rs797588198 22 G>E No EVA
rs465890288 25 C>G No EVA
rs436030302 27 E>G No EVA
rs454733607 28 I>V No EVA
rs452351489 30 T>P No EVA
rs470870195 31 E>* No EVA
rs441211758 36 L>Q No EVA
rs459698623 40 Q>E No EVA
rs481330557 40 Q>H No EVA
rs463685546 43 E>A No EVA
rs442113653 43 E>Q No EVA
rs482253225 44 A>P No EVA
rs446211163 45 V>L No EVA
rs480124559 46 Y>* No EVA
rs464840680 46 Y>F No EVA
rs464840680 46 Y>S No EVA
rs447203787 48 R>G No EVA
rs465726754 51 G>C No EVA
rs137429661 53 E>G No EVA
rs472497378 124 Q>* No EVA
rs442787005 139 M>I No EVA
rs461242904 141 G>R No EVA
rs443599553 142 V>I No EVA
rs459695845 179 S>R No EVA
rs474881416 180 M>V No EVA
rs442178742 182 D>E No EVA
rs457368649 194 R>H No EVA
rs463925391 196 K>* No EVA
rs446377016 196 K>N No EVA
rs482470372 196 K>T No EVA
rs458355983 197 A>T No EVA
rs469400461 261 D>H No EVA
rs461106411 263 R>I No EVA
rs875994461 271 T>P No EVA
rs876540797 273 T>P No EVA
rs876083889 277 E>K No EVA
rs460575923 309 E>V No EVA
rs479003074 313 Q>* No EVA
rs449320912 320 K>N No EVA
rs467877411 321 F>V No EVA
rs457432438 359 V>G No EVA
rs475985951 383 V>A No EVA
rs480683045 399 C>G No EVA
rs462844462 455 F>L No EVA
rs441023818 461 C>W No EVA
rs454141533 486 E>* No EVA
rs470581768 492 V>I No EVA
rs440938671 495 H>P No EVA
rs452404953 496 K>E No EVA
rs459437712 497 L>P No EVA
rs381627266 498 R>Q No EVA
rs448165360 500 G>A No EVA
rs463503451 505 T>A No EVA
rs463503451 505 T>S No EVA
rs481961288 506 L>R No EVA
rs434572543 510 Q>H No EVA
rs464571118 512 G>V No EVA
rs434770721 513 V>G No EVA
rs446913748 514 T>N No EVA
rs468648929 524 L>V No EVA
rs435798869 525 Q>K No EVA
rs475986093 528 K>N No EVA
rs457493306 528 K>T No EVA
rs433485179 531 T>P No EVA
rs451975276 533 G>D No EVA
rs440746087 534 I>N No EVA
rs452952976 535 E>G No EVA
rs441653743 542 L>P No EVA
rs441653743 542 L>Q No EVA
rs463413454 544 F>I No EVA
rs464637801 548 L>P No EVA
rs453565073 555 S>G No EVA
rs876402047 558 I>V No EVA
rs135681699 559 S>A No EVA
rs435919902 559 S>F No EVA
rs457618014 560 T>A No EVA
rs454039910 626 T>P No EVA
rs472192802 695 T>P No EVA
rs442382160 697 N>T No EVA
rs436927598 699 L>M No EVA
rs452049568 700 G>V No EVA
rs459499558 714 Y>S No EVA
rs474955642 715 L>P No EVA
rs441890971 716 T>A No EVA
rs441890971 716 T>P No EVA
rs482238623 720 T>N No EVA
rs463809105 720 T>P No EVA
rs446131505 722 T>P No EVA
rs458206310 729 R>L No EVA
rs447110374 740 E>Q No EVA
rs444556555 742 V>E No EVA
rs444556555 742 V>G No EVA
rs463145641 743 T>I No EVA
rs445494456 744 E>* No EVA
rs464001652 749 W>L No EVA
rs479167150 751 A>T No EVA
rs446523890 752 N>K No EVA
rs468213516 753 S>A No EVA
rs457107129 759 R>L No EVA
rs469204454 763 A>T No EVA
rs433087003 764 E>D No EVA
rs451576198 766 R>H No EVA
rs473395358 771 L>P No EVA
rs455832963 773 I>L No EVA
rs474342312 773 I>T No EVA
rs444502540 775 F>L No EVA
rs463154581 778 E>Q No EVA
rs478169658 779 D>Y No EVA
rs439066352 781 K>E No EVA
rs460654989 781 K>R No EVA
rs479230482 782 R>S No EVA
rs446441900 783 L>M No EVA
rs461737373 783 L>Q No EVA

No associated diseases with Q3MHG0

1 regional properties for Q3MHG0

Type Name Position InterPro Accession
domain Conserved oligomeric Golgi complex, subunit 4 188 - 498 IPR013167

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Golgi transport complex A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
Golgi vesicle prefusion complex stabilization The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06096 COG4 Conserved oligomeric Golgi complex subunit 4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q95TN4 Cog4 Conserved oligomeric Golgi complex subunit 4 Drosophila melanogaster (Fruit fly) PR
Q9H9E3 COG4 Conserved oligomeric Golgi complex subunit 4 Homo sapiens (Human) PR
Q8R1U1 Cog4 Conserved oligomeric Golgi complex subunit 4 Mus musculus (Mouse) PR
Q8L838 COG4 Conserved oligomeric Golgi complex subunit 4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADLDSPQKL SGVPRPPDGV GGGSCSEIST ELIRSLTDLQ ELEAVYERLC GEEKVVEREL
70 80 90 100 110 120
DALLEQQNTI ESKMVTLHRM GPNLQLIEGD AKQLAGMITF TCNLAENVSS KVRQLDLAKN
130 140 150 160 170 180
RLYQAIQRAD DILDLKFCMD GVQTALRNED YEQAAAHIHR YLCLDKSVIE LSRQGKEGSM
190 200 210 220 230 240
IDANLKLLQE AEQRLKAIVT EKFAVATKEG DLPQVERFFK IFPLLGLHEE GLSKFSEYLC
250 260 270 280 290 300
KQVASKAEEN LLLVLGTDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLY
310 320 330 340 350 360
TLIKYLQVEC DRQVEKVVDK FIKQRDYRQQ FRHVQSNLMR NSTSEKIEPR ELDPILTEVT
370 380 390 400 410 420
LMNARSELYL RFLRKRISSD FEVGDSMASE EVKQEHQKCL DKLLNNCLLS CTMQELIGLY
430 440 450 460 470 480
ITMEEYFMRE TVNKAVALDT YEKGQLTSSM VDDVFYIVKK CIGRALSSSS IDCLCAMINL
490 500 510 520 530 540
ATTELESDFR DVLCHKLRMG FPATTLQDIQ RGVTSAVSIM HSSLQQGKFD TKGIESTDEA
550 560 570 580 590 600
KLSFLVTLNN VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSGKF
610 620 630 640 650 660
RDLLQEGLTE LNSTAIKPQV QPWINTFLSV SHNIEEEEFS DYEANDPWVQ QFILNLEQQM
670 680 690 700 710 720
AEFKAGLSPV IYDSLTSLMT SLVAVELEKV VLKSTFNRLG GLQFDKELRS LIAYLTTVTT
730 740 750 760 770 780
WTIRDKFARL SQMATILNLE RVTEILDYWG ANSGPLTWRL TPAEVRQVLA LRIDFRSEDI
KRLRL