Q95JH2
PR
Gene name |
AGPAT1 |
Protein name |
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha |
Names |
1-acylglycerol-3-phosphate O-acyltransferase 1, 1-AGP acyltransferase 1, 1-AGPAT 1, Lysophosphatidic acid acyltransferase alpha, LPAAT-alpha |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282137 |
EC number |
2.3.1.51: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q95JH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q95JH2-F1 | Predicted | AlphaFoldDB |
87 variants for Q95JH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs441511870 | 9 | T>A | No | EVA | |
| rs481625021 | 10 | L>V | No | EVA | |
| rs461089671 | 20 | L>P | No | EVA | |
| rs449700987 | 24 | T>P | No | EVA | |
| rs464941045 | 27 | F>V | No | EVA | |
| rs432228344 | 31 | S>I | No | EVA | |
| rs447500572 | 36 | F>V | No | EVA | |
| rs436194852 | 43 | G>S | No | EVA | |
| rs454875375 | 45 | I>V | No | EVA | |
| rs476770484 | 46 | L>P | No | EVA | |
| rs452453129 | 47 | F>C | No | EVA | |
| rs437295654 | 47 | F>L | No | EVA | |
| rs460073827 | 50 | V>E | No | EVA | |
| rs475195706 | 52 | A>P | No | EVA | |
| rs442269484 | 53 | I>L | No | EVA | |
| rs460989647 | 56 | C>G | No | EVA | |
| rs482737598 | 56 | C>W | No | EVA | |
| rs453907051 | 57 | A>D | No | EVA | |
| rs449724020 | 58 | V>E | No | EVA | |
| rs469696151 | 68 | I>F | No | EVA | |
| rs469696151 | 68 | I>L | No | EVA | |
| rs433355809 | 68 | I>S | No | EVA | |
| rs469696151 | 68 | I>V | No | EVA | |
| rs451776440 | 70 | R>L | No | EVA | |
| rs434405650 | 74 | L>V | No | EVA | |
| rs474404777 | 75 | H>L | No | EVA | |
| rs463649685 | 77 | K>* | No | EVA | |
| rs475673767 | 78 | Y>F | No | EVA | |
| rs475673767 | 78 | Y>S | No | EVA | |
| rs439507073 | 79 | L>R | No | EVA | |
| rs457885586 | 84 | V>G | No | EVA | |
| rs479616565 | 86 | V>G | No | EVA | |
| rs446955173 | 89 | A>V | No | EVA | |
| rs462292263 | 90 | H>P | No | EVA | |
| rs480631653 | 91 | H>P | No | EVA | |
| rs480631653 | 91 | H>R | No | EVA | |
| rs450832741 | 99 | V>L | No | EVA | |
| rs469420004 | 101 | V>A | No | EVA | |
| rs469420004 | 101 | V>G | No | EVA | |
| rs433423526 | 108 | L>P | No | EVA | |
| rs472414292 | 112 | G>E | No | EVA | |
| rs443074292 | 113 | M>L | No | EVA | |
| rs461706837 | 115 | E>G | No | EVA | |
| rs450300251 | 116 | V>G | No | EVA | |
| rs483250872 | 116 | V>L | No | EVA | |
| rs459099104 | 118 | P>Q | No | EVA | |
| rs466557585 | 120 | R>P | No | EVA | |
| rs449062407 | 121 | C>S | No | EVA | |
| rs467724318 | 121 | C>W | No | EVA | |
| rs456284592 | 123 | P>T | No | EVA | |
| rs471412662 | 124 | I>F | No | EVA | |
| rs471412662 | 124 | I>L | No | EVA | |
| rs432410503 | 128 | E>Q | No | EVA | |
| rs472401857 | 139 | C>G | No | EVA | |
| rs442808783 | 142 | A>V | No | EVA | |
| rs476906914 | 144 | V>G | No | EVA | |
| rs443916943 | 148 | D>Y | No | EVA | |
| rs454892584 | 203 | V>G | No | EVA | |
| rs476628652 | 225 | T>P | No | EVA | |
| rs439462249 | 231 | V>G | No | EVA | |
| rs457947066 | 233 | V>G | No | EVA | |
| rs462081493 | 237 | V>G | No | EVA | |
| rs480693165 | 238 | P>T | No | EVA | |
| rs469541254 | 241 | G>W | No | EVA | |
| rs478323089 | 252 | D>G | No | EVA | |
| rs445371949 | 253 | R>S | No | EVA | |
| rs467003946 | 254 | V>G | No | EVA | |
| rs453022330 | 259 | L>P | No | EVA | |
| rs468141969 | 262 | F>I | No | EVA | |
| rs435202154 | 263 | R>G | No | EVA | |
| rs457156532 | 263 | R>P | No | EVA | |
| rs439554801 | 265 | I>M | No | EVA | |
| rs475665254 | 265 | I>T | No | EVA | |
| rs380643365 | 267 | T>A | No | EVA | |
| rs473205258 | 268 | D>G | No | EVA | |
| rs440487056 | 270 | R>G | No | EVA | |
| rs445522757 | 278 | K>M | No | EVA | |
| rs478261528 | 278 | K>Q | No | EVA | |
| rs436193604 | 279 | P>A | No | EVA | |
| rs479288196 | 279 | P>L | No | EVA | |
| rs468337396 | 281 | G>R | No | EVA | |
| rs435288604 | 282 | V>A | No | EVA | |
| rs435288604 | 282 | V>G | No | EVA | |
| rs450471296 | 283 | G>C | No | EVA | |
| rs433013389 | 285 | A>V | No | EVA | |
| rs451651072 | 286 | G>V | No | EVA | |
| rs473170599 | 288 | L>G | No | EVA |
No associated diseases with Q95JH2
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.51 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| positive regulation of cytokine production | Any process that activates or increases the frequency, rate or extent of production of a cytokine. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33333 | SLC1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O15120 | AGPAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Homo sapiens (Human) | PR |
| Q99943 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Homo sapiens (Human) | PR |
| Q8K3K7 | Agpat2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Mus musculus (Mouse) | PR |
| Q9LLY4 | BAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase BAT2, chloroplastic | Brassica napus (Rape) | PR |
| Q8GXU8 | LPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELWPGAGTL | LLLLFLLLLL | LLPTLWFCSP | SAKYFFKMAF | YNGWILFLAV | LAIPVCAVRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RNVENMKILR | LMLLHIKYLY | GIRVEVRGAH | HFPPSQPYVV | VSNHQSSLDL | LGMMEVLPGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CVPIAKRELL | WAGSAGLACW | LAGVIFIDRK | RTGDAISVMS | EVAQTLLTQD | VRVWVFPEGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNHNGSMLPF | KRGAFHLAVQ | AQVPIVPIVM | SSYQDFYCKK | ERRFTSGRCQ | VRVLPPVPTE |
| 250 | 260 | 270 | 280 | ||
| GLKPDDVPAL | ADRVRHSMLT | VFREISTDGR | GGGDYLKKPG | GVGEAGL |