P33333
Gene name |
SLC1 |
Protein name |
1-acyl-sn-glycerol-3-phosphate acyltransferase |
Names |
1-AGP acyltransferase, 1-AGPAT, Lysophosphatidic acid acyltransferase, LPAAT, Sphingolipid compensation protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL052C |
EC number |
2.3.1.23: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P33333
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P33333-F1 | Predicted | AlphaFoldDB |
5 variants for P33333
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-363511 | 25 | F>L | No | SGRP | |
| 44 | Q>L | allele suppressor SLC1-1 [UniProt] | No | ||
| s04-363256 | 110 | V>F | No | SGRP | |
| s04-363194 | 130 | R>S | No | SGRP | |
| s04-362864 | 240 | D>E | No | SGRP |
No associated diseases with P33333
1 regional properties for P33333
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SWIRM domain | 266 - 363 | IPR007526 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.23 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| 1-acylglycerophosphoethanolamine O-acyltransferase activity | Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| glycerophospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q95JH2 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Bos taurus (Bovine) | PR |
| Q99943 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Homo sapiens (Human) | PR |
| O15120 | AGPAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Homo sapiens (Human) | PR |
| Q8K3K7 | Agpat2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Mus musculus (Mouse) | PR |
| Q9LLY4 | BAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase BAT2, chloroplastic | Brassica napus (Rape) | PR |
| Q8GXU8 | LPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVIGRFLYY | LRSVLVVLAL | AGCGFYGVIA | SILCTLIGKQ | HLAQWITARC | FYHVMKLMLG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDVKVVGEEN | LAKKPYIMIA | NHQSTLDIFM | LGRIFPPGCT | VTAKKSLKYV | PFLGWFMALS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTYFLDRSKR | QEAIDTLNKG | LENVKKNKRA | LWVFPEGTRS | YTSELTMLPF | KKGAFHLAQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKIPIVPVVV | SNTSTLVSPK | YGVFNRGCMI | VRILKPISTE | NLTKDKIGEF | AEKVRDQMVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLKEIGYSPA | INDTTLPPQA | IEYAALQHDK | KVNKKIKNEP | VPSVSISNDV | NTHNEGSSVK |
| KMH |