O15120
PR
Gene name |
AGPAT2 |
Protein name |
1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
Names |
1-acylglycerol-3-phosphate O-acyltransferase 2, 1-AGP acyltransferase 2, 1-AGPAT 2, Lysophosphatidic acid acyltransferase beta, LPAAT-beta |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:10555 |
EC number |
2.3.1.51: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O15120
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O15120-F1 | Predicted | AlphaFoldDB |
328 variants for O15120
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs886063723 RCV000399921 |
1 | M>missing | Congenital generalized lipodystrophy [ClinVar] | Yes |
ClinVar dbSNP |
|
CA375588437 RCV001174398 rs1284278396 |
10 | A>G | Monogenic diabetes [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
RCV000249797 RCV000346337 RCV001651194 rs745429291 |
17 | L>missing | Congenital generalized lipodystrophy [ClinVar] | Yes |
ClinVar dbSNP |
|
CA16042197 rs1057517651 RCV000412547 |
65 | W>* | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV000445545 CA5343113 rs563539429 RCV001169548 RCV001865409 |
67 | V>M | Monogenic diabetes Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
rs104894093 RCV001701561 CA277942 RCV000007003 |
68 | R>* | Variant assessed as Somatic; 0.0 impact. Congenital generalized lipodystrophy type 1 [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs140995132 RCV002530621 RCV002485514 RCV000664131 CA5343109 |
70 | F>V | Monogenic diabetes Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000116251 rs151053652 CA230857 RCV002483193 |
77 | R>C | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002558770 rs375796317 RCV002497607 CA5343102 RCV001174397 |
77 | R>H | Monogenic diabetes Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs193920848 RCV000149182 |
83 | P>missing | Malignant tumor of prostate [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001169547 rs142176861 RCV000277912 CA5343091 |
90 | R>H | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000664130 CA375583730 rs1554754454 |
92 | C>R | Monogenic diabetes [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
COSM1461207 CA5343086 rs764260414 RCV000412496 |
100 | S>N | Variant assessed as Somatic; 0.0 impact. large_intestine Congenital generalized lipodystrophy type 1 [NCI-TCGA, Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ExAC NCI-TCGA dbSNP gnomAD |
|
CA5343082 RCV000418715 rs746809573 RCV000389300 |
105 | M>I | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs1588263957 RCV001819690 RCV000985088 |
112 | P>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV000412550 rs886063722 CA10633299 |
112 | P>L | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
RCV000969569 RCV000445461 CA5343042 rs142145391 |
114 | R>C | Monogenic diabetes [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002467800 CA5343037 rs114782902 RCV000445386 |
120 | K>R | Monogenic diabetes Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001167655 CA5343036 rs369878933 |
121 | R>G | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs387906355 RCV000007005 |
128 | P>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
|
rs537737741 RCV001167654 CA5343024 |
133 | M>V | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD |
|
CA278000 RCV000193026 VAR_017328 rs797045222 |
136 | G>R | Congenital generalized lipodystrophy type 1 CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt dbSNP gnomAD |
|
rs372935354 CA5343014 RCV001167653 |
139 | F>V | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs387906356 RCV000007007 |
140 | F>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
| VAR_017326 | 140 | F>del | CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity [UniProt] | Yes | UniProt |
|
rs1230993149 RCV001174393 RCV002558769 CA375581980 |
152 | V>A | Monogenic diabetes Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
CA5342999 RCV003163384 rs150530734 RCV003106137 RCV001174396 |
154 | A>D | Monogenic diabetes Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000445508 RCV000883942 rs142993240 RCV001167076 RCV000193694 CA207355 COSM4163570 |
159 | R>C | thyroid Monogenic diabetes Congenital generalized lipodystrophy type 1 [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000354825 rs374919945 CA5342995 |
159 | R>L | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA16043672 RCV000414972 rs1057518714 |
168 | W>* | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
rs1564290914 RCV000754914 |
172 | E>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA5342949 rs748157664 RCV000412645 RCV000494007 |
172 | E>K | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs1057517653 RCV000412491 |
180 | D>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA277952 RCV000007010 rs121908926 |
190 | Y>* | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
CA5342909 rs372408400 RCV000358360 |
202 | V>M | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000754915 rs1564290079 |
208 | S>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA5342897 rs142248792 RCV000445463 RCV000909273 RCV002467799 |
214 | K>E | Monogenic diabetes Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA277949 rs121908925 RCV000007008 |
215 | K>* | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV000412630 rs138994150 CA5342894 RCV000880987 |
216 | K>* | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA5342893 RCV001167074 RCV001397951 rs143244920 RCV002557435 |
216 | K>M | Congenital generalized lipodystrophy type 1 Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA16042193 RCV000412578 rs1057517655 |
226 | Q>* | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
rs104894100 RCV000007006 CA277946 VAR_017327 |
228 | L>P | Congenital generalized lipodystrophy type 1 CGL1; reduced 1-acyl-sn-glycerol-3-phosphate acyltransferase activity [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
CA375577599 RCV000788112 rs536777709 |
233 | T>N | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD |
|
RCV000412633 CA5342848 rs200656731 |
238 | A>G | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000594308 RCV001165478 rs145975461 VAR_017325 RCV002062081 CA5342845 |
239 | A>V | Congenital generalized lipodystrophy type 1 CGL1; 90% of wild-type 1-acyl-sn-glycerol-3-phosphate acyltransferase activity [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA5342829 rs368090654 RCV001165476 RCV002558606 |
250 | R>Q | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA5342830 RCV000390096 rs767338891 |
250 | R>W | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000412504 rs1057517656 |
252 | M>missing | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA5342816 RCV001169501 rs17848858 RCV002557465 |
263 | P>L | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
rs142417583 CA5342808 RCV000445394 RCV000965123 RCV001169500 |
270 | A>V | Monogenic diabetes Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA5342803 rs368902934 RCV000292158 |
274 | V>M | Congenital generalized lipodystrophy type 1 [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA375588548 rs1364637147 |
2 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1364637147 CA375588550 |
2 | E>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1588270266 CA375588512 |
4 | W>* | No |
ClinGen Ensembl |
|
|
CA201641542 rs567515545 |
5 | P>L | No |
ClinGen 1000Genomes |
|
|
CA5343190 rs772720511 |
5 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA375588495 rs1278572636 |
6 | C>R | No |
ClinGen gnomAD |
|
|
rs774927104 CA5343188 |
7 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs769132436 CA5343187 |
8 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA201641519 rs550860290 |
11 | L>P | No |
ClinGen 1000Genomes gnomAD |
|
|
rs550860290 CA375588425 |
11 | L>R | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1403374054 CA375588388 |
13 | L>F | No |
ClinGen TOPMed |
|
|
RCV000722635 rs745429291 |
16 | L>missing | No |
ClinVar dbSNP |
|
|
CA375588353 rs1156772737 |
17 | L>V | No |
ClinGen gnomAD |
|
|
rs745978420 CA5343183 |
17 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs1188776097 CA375588337 |
18 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1188776097 CA375588335 |
18 | V>G | No |
ClinGen TOPMed gnomAD |
|
|
rs758336307 CA5343181 |
18 | V>L | No |
ClinGen ExAC |
|
|
rs1564296483 CA375588332 |
19 | Q>E | No |
ClinGen Ensembl |
|
|
CA201641461 rs974068780 |
21 | S>N | No |
ClinGen Ensembl |
|
|
rs765072538 CA5343175 |
22 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375588297 rs765072538 |
22 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1486389980 CA375588294 |
22 | R>H | No |
ClinGen gnomAD |
|
|
rs1260518080 CA375588281 |
23 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA5343174 rs530668813 |
24 | A>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1024066065 CA201641456 |
24 | A>V | No |
ClinGen gnomAD |
|
|
rs1273212998 CA375588267 |
25 | E>K | No |
ClinGen gnomAD |
|
|
CA5343172 rs766080263 |
29 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1382453793 CA375588187 |
29 | K>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1382453793 CA375588189 |
29 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA375588191 rs1382453793 |
29 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1360933401 CA375588177 |
30 | V>I | No |
ClinGen gnomAD |
|
|
rs1012305332 CA201641451 |
31 | A>S | No |
ClinGen gnomAD |
|
|
CA375588157 rs1438463501 |
31 | A>V | No |
ClinGen gnomAD |
|
|
CA375588129 rs1460980367 |
34 | C>G | No |
ClinGen gnomAD |
|
|
CA5343170 rs138811198 |
35 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375588109 rs1205915727 |
35 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA375588104 COSM1132546 rs1173020252 |
36 | L>Q | Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs767135270 CA5343169 |
37 | C>* | No |
ClinGen ExAC gnomAD |
|
|
CA375588076 rs1588270124 |
38 | F>S | No |
ClinGen Ensembl |
|
|
rs762472184 CA5343168 |
39 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs972288593 CA201641437 |
40 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1254174891 CA375588032 |
42 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1213688450 CA375588027 |
42 | A>V | No |
ClinGen gnomAD |
|
|
rs375485327 CA5343166 |
45 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA375587994 rs1227650315 |
46 | L>F | No |
ClinGen gnomAD |
|
|
CA5343165 rs749691219 |
46 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA375587985 rs1220709454 |
47 | V>I | No |
ClinGen gnomAD |
|
|
CA5343161 rs559044334 |
51 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5343159 rs748131425 |
52 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343160 rs757315738 |
52 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA5343158 rs778789592 |
53 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs754824584 CA5343157 |
54 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754824584 CA375587899 |
54 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375587891 rs1193488029 |
55 | R>Q | No |
ClinGen gnomAD |
|
|
rs1239418038 CA375587868 |
57 | V>E | No |
ClinGen gnomAD |
|
|
CA201641408 rs999677156 |
57 | V>M | No |
ClinGen Ensembl |
|
|
CA5343154 rs755862737 |
58 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs761378691 CA5343152 |
60 | M>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343151 rs761378691 |
60 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761378691 CA375587831 |
60 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343153 rs750090730 |
60 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA375584171 rs772032254 |
62 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772032254 CA5343121 |
62 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773409087 CA5343122 |
62 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs150180733 CA5343119 |
63 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs545434931 CA5343120 |
63 | I>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs781074178 CA5343116 |
64 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs552941425 CA5343117 |
64 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs781074178 CA375584162 |
64 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA375584131 rs1416598711 |
66 | F>S | No |
ClinGen gnomAD |
|
|
CA5343115 rs756970061 |
66 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA375584121 CA5343114 rs563539429 |
67 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5343112 rs753285203 |
68 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs765693486 CA5343111 |
69 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA5343110 rs140995132 |
70 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375584063 rs1214311068 |
71 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA5343107 rs760946018 |
72 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA5343108 rs766725928 |
72 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs773288073 CA5343106 |
73 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs761832220 CA375584012 |
74 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767679550 CA5343105 |
74 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
CA375584010 CA5343103 rs556809277 |
75 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA591184745 rs1328499448 |
76 | L>R | No |
ClinGen gnomAD |
|
|
CA5343101 rs543374987 |
78 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5343099 rs746723029 |
79 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 81 | R>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375583926 rs1167031646 |
81 | R>Q | No |
ClinGen gnomAD |
|
|
CA5343098 rs534706099 |
81 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs758027160 CA5343097 |
82 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA375583919 rs1474296766 |
82 | D>N | No |
ClinGen gnomAD |
|
|
rs1194107841 CA375583897 |
83 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs369342642 CA5343095 |
84 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5343094 rs755548321 |
84 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA375583785 rs1421120588 |
89 | A>S | No |
ClinGen gnomAD |
|
|
COSM1182228 rs754330975 CA5343093 |
90 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs754330975 CA375583777 |
90 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343092 rs142176861 |
90 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1176662324 CA375583744 |
91 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs997858799 CA201630564 |
92 | C>S | No |
ClinGen TOPMed gnomAD |
|
|
CA5343089 rs767657638 |
93 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs886043265 RCV000281033 |
94 | I>missing | No |
ClinVar dbSNP |
|
|
rs1415497065 CA375583578 |
95 | V>I | No |
ClinGen TOPMed |
|
|
rs1301941606 CA375583518 |
96 | S>C | No |
ClinGen gnomAD |
|
|
CA201630554 rs994062536 |
99 | Q>H | No |
ClinGen Ensembl |
|
|
rs1354671151 CA375583402 |
100 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
CA5343084 rs776686392 |
103 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs770888755 CA5343083 |
104 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375583218 rs1349711728 |
106 | G>C | No |
ClinGen TOPMed |
|
|
CA375582959 rs1455703917 |
108 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA5343045 rs765404852 |
110 | V>F | No |
ClinGen ExAC gnomAD |
|
|
rs1268021829 CA375582891 |
111 | L>I | No |
ClinGen TOPMed |
|
|
CA375582883 rs1463201340 |
111 | L>P | No |
ClinGen TOPMed |
|
|
CA5343043 rs750354844 |
113 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA5343041 rs746314526 COSM1461206 |
114 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA375582817 rs1242036472 |
115 | C>R | No |
ClinGen gnomAD |
|
|
rs73668354 CA201630147 |
115 | C>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs371597242 CA5343039 |
116 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA201630131 rs1021163877 |
117 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
CA201630127 rs933473488 |
117 | Q>P | No |
ClinGen TOPMed |
|
|
CA375582728 rs1297327095 |
119 | A>G | No |
ClinGen gnomAD |
|
|
rs1319531981 CA375582740 |
119 | A>T | No |
ClinGen gnomAD |
|
|
CA375582700 rs1295243261 |
121 | R>Q | No |
ClinGen gnomAD |
|
|
CA5343035 COSM1182227 rs369878933 |
121 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
RCV000428956 rs1057522706 CA16605653 |
122 | E>A | No |
ClinGen ClinVar dbSNP gnomAD |
|
|
rs1443022263 CA375582686 |
122 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA5343032 rs747398697 |
126 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA375582555 rs1419266272 |
127 | G>E | No |
ClinGen gnomAD |
|
|
rs758697932 CA5343031 |
127 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758697932 CA5343030 |
127 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755055909 CA5343027 |
129 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs778908749 CA5343028 |
129 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375582480 rs1564291266 |
130 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA5343026 rs753822306 |
132 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343025 rs551034811 |
132 | I>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1487258258 CA375582435 |
132 | I>T | No |
ClinGen gnomAD |
|
|
CA5343023 rs751365084 |
133 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA375582397 rs1588263792 |
134 | Y>S | No |
ClinGen Ensembl |
|
|
CA375582383 rs1343663871 |
135 | L>F | No |
ClinGen TOPMed |
|
|
rs775097208 CA5343020 |
136 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA5343018 rs759115310 |
137 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA201629968 rs759115310 |
137 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA5343016 rs771482666 |
138 | V>I | No |
ClinGen ExAC TOPMed |
|
| rs1181209658 | 138 | V>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs773771905 CA5343013 |
140 | F>I | No |
ClinGen ExAC gnomAD |
|
|
rs200664359 CA201629941 |
141 | I>M | No |
ClinGen 1000Genomes |
|
|
rs748422913 CA5343012 |
142 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748422913 CA5343011 |
142 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343009 rs749401965 |
143 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343008 rs749401965 |
143 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343010 rs779228870 |
143 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1564291192 CA375582176 |
144 | Q>P | No |
ClinGen Ensembl |
|
|
rs55755415 CA5343006 |
145 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5343005 rs200070319 |
145 | R>H | No |
ClinGen ESP ExAC gnomAD |
|
|
rs55755415 CA201629915 |
145 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1252060863 CA375582126 |
146 | S>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1371561893 CA375582135 |
146 | S>P | No |
ClinGen TOPMed |
|
|
CA5343003 rs758156274 |
147 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5343004 rs758156274 |
147 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752391395 CA5343002 |
147 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764964329 CA5343001 |
148 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs759050377 CA5343000 |
149 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA375582008 rs1348403217 |
151 | T>A | No |
ClinGen gnomAD |
|
|
rs150530734 CA201629877 |
154 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5342997 rs747413162 |
155 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1249417092 CA375581886 |
156 | L>V | No |
ClinGen TOPMed |
|
|
CA201629850 rs367594835 |
157 | G>C | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA375581831 rs1588263624 |
158 | E>G | No |
ClinGen Ensembl |
|
|
CA375581839 rs1266548148 |
158 | E>K | No |
ClinGen TOPMed |
|
|
rs374919945 CA5342994 |
159 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs749471921 CA5342992 |
160 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA5342993 rs577846814 |
160 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5342990 rs564197398 |
162 | R>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA201629800 rs200183102 |
163 | E>K | No |
ClinGen 1000Genomes |
|
|
CA201629794 rs1048261547 |
164 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA375581485 rs1289409198 |
166 | K>E | No |
ClinGen gnomAD |
|
|
rs541978825 CA5342954 |
167 | V>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5342952 rs759686675 |
170 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA375581316 rs1252287949 |
171 | P>S | No |
ClinGen gnomAD |
|
|
CA375581294 rs748157664 |
172 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1440988878 CA375581278 |
173 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA5342948 rs774187550 |
175 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375581223 rs1350421406 |
176 | N>D | No |
ClinGen TOPMed |
|
|
CA5342946 rs749052076 |
177 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779132574 CA201629338 |
178 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA375581086 rs1298569587 |
180 | D>E | No |
ClinGen TOPMed |
|
|
CA5342945 rs373343259 |
180 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 184 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 185 | K>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375580941 rs1198278973 |
186 | K>E | No |
ClinGen gnomAD |
|
|
CA375580933 rs1564290861 RCV000722740 |
186 | K>T | No |
ClinGen ClinVar Ensembl dbSNP |
|
|
CA201629300 rs917659244 |
188 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA5342940 rs751036761 |
188 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs917659244 CA201629299 |
188 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA375580797 rs1340565783 |
192 | A>V | No |
ClinGen gnomAD |
|
|
CA375580789 rs1036718579 |
193 | V>F | No |
ClinGen TOPMed |
|
|
rs1036718579 CA201629262 |
193 | V>I | No |
ClinGen TOPMed |
|
|
rs1283019657 CA375580767 |
194 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA201629258 rs373943261 |
195 | A>G | No |
ClinGen Ensembl |
|
| TCGA novel | 195 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs17855341 CA201627695 |
200 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs17855341 CA375578889 |
200 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5342912 rs17855341 |
200 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372408400 CA375578753 |
202 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5342908 rs776425895 |
204 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA5342906 rs746667575 |
206 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA201627675 rs897305145 |
208 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
CA5342904 rs771547310 |
208 | S>P | No |
ClinGen ExAC TOPMed |
|
|
rs748693822 CA5342903 |
209 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs377267603 CA5342902 |
210 | F>S | No |
ClinGen ESP ExAC TOPMed |
|
| TCGA novel | 212 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs754208307 CA5342899 |
212 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5342898 rs780464197 |
213 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA5342895 rs767537103 |
215 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1237838088 CA375578166 |
219 | T>A | No |
ClinGen TOPMed |
|
|
rs1412078301 CA375578150 |
219 | T>I | No |
ClinGen gnomAD |
|
|
CA375577816 rs1381301615 |
221 | G>A | No |
ClinGen gnomAD |
|
|
CA375577775 rs1588261109 |
223 | V>A | No |
ClinGen Ensembl |
|
|
CA375577791 rs200073215 |
223 | V>I | No |
ClinGen 1000Genomes gnomAD |
|
|
CA201626941 rs200073215 |
223 | V>L | No |
ClinGen 1000Genomes gnomAD |
|
|
CA201626932 rs765479536 |
224 | T>R | No |
ClinGen Ensembl |
|
|
rs557103117 CA5342857 |
225 | V>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5342854 rs757623351 |
227 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375577680 rs1255380257 |
229 | E>K | No |
ClinGen gnomAD |
|
|
CA5342853 rs747223219 |
231 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs536777709 CA5342852 |
233 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs138232867 CA5342851 |
235 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766362929 CA5342850 |
236 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 237 | T>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5342847 COSM238729 rs200656731 |
238 | A>V | Variant assessed as Somatic; 5.107e-05 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA375577479 rs145975461 |
239 | A>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs762542535 CA5342843 |
240 | D>A | No |
ClinGen ExAC |
|
|
rs11545228 CA201626880 |
241 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs11545228 CA5342841 |
241 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5342840 rs11545228 |
241 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 241 | V>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777195971 CA5342839 |
242 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs553740204 CA5342837 |
243 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs553740204 CA5342838 |
243 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs778853584 CA375577369 |
245 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5342833 rs778853584 |
245 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs958545912 CA201626858 |
247 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1588260954 CA375577346 |
247 | T>P | No |
ClinGen Ensembl |
|
|
CA375577332 rs1588260943 |
248 | C>G | No |
ClinGen Ensembl |
|
|
CA375577314 rs1588260926 |
249 | H>P | No |
ClinGen Ensembl |
|
|
CA201626841 rs1003229436 |
249 | H>Y | No |
ClinGen Ensembl |
|
|
rs1328715652 CA375577294 |
251 | A>T | No |
ClinGen gnomAD |
|
|
CA375577279 rs1359921826 |
252 | M>I | No |
ClinGen TOPMed |
|
|
RCV000722649 CA375577283 rs1247427045 |
252 | M>T | No |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
|
CA5342828 rs751303704 |
252 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs763816384 CA5342827 |
253 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA5342826 rs147616533 |
254 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA201626821 rs147616533 |
254 | T>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA201626811 rs141456385 |
255 | T>I | No |
ClinGen ESP gnomAD |
|
|
rs764643486 CA5342824 |
256 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1320609779 CA375577243 |
256 | F>L | No |
ClinGen gnomAD |
|
|
rs1164691436 CA375577217 |
258 | H>R | No |
ClinGen gnomAD |
|
|
CA201626809 rs1011578726 |
259 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs760141111 CA5342823 |
260 | S>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5342822 rs777248850 |
261 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs530977763 CA5342821 |
261 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs773653710 CA5342819 |
262 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5342814 rs373878123 |
264 | Q>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375577108 rs370809970 |
266 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs751365063 CA5342811 |
267 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1362416121 CA375577090 |
268 | A>S | No |
ClinGen gnomAD |
|
|
rs528513856 CA5342809 |
268 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1387024488 CA375577074 |
269 | T>I | No |
ClinGen gnomAD |
|
|
rs1387024488 CA375577077 |
269 | T>N | No |
ClinGen gnomAD |
|
|
CA375577060 rs1390698959 |
271 | G>E | No |
ClinGen gnomAD |
|
|
CA201623549 rs1051343001 |
272 | S>C | No |
ClinGen Ensembl |
|
|
rs753350881 CA5342805 |
273 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA375576125 rs1588260774 |
273 | G>S | No |
ClinGen Ensembl |
|
|
CA375576114 rs368902934 |
274 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375576098 rs1452388592 |
275 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA375576097 rs1452388592 |
275 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA5342802 rs773769888 |
276 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375576069 rs1344825112 |
277 | A>V | No |
ClinGen TOPMed gnomAD |
1 associated diseases with O15120
[MIM: 608594]: Congenital generalized lipodystrophy 1 (CGL1)
An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. {ECO:0000269|PubMed:11967537, ECO:0000269|PubMed:15629135}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. {ECO:0000269|PubMed:11967537, ECO:0000269|PubMed:15629135}. Note=The disease is caused by variants affecting the gene represented in this entry.
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.51 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| specific granule membrane | The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| epidermis development | The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| positive regulation of cytokine production | Any process that activates or increases the frequency, rate or extent of production of a cytokine. |
| positive regulation of cytokine-mediated signaling pathway | Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33333 | SLC1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q95JH2 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Bos taurus (Bovine) | PR |
| Q99943 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Homo sapiens (Human) | PR |
| Q8K3K7 | Agpat2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Mus musculus (Mouse) | PR |
| Q9LLY4 | BAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase BAT2, chloroplastic | Brassica napus (Rape) | PR |
| Q8GXU8 | LPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELWPCLAAA | LLLLLLLVQL | SRAAEFYAKV | ALYCALCFTV | SAVASLVCLL | RHGGRTVENM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SIIGWFVRSF | KYFYGLRFEV | RDPRRLQEAR | PCVIVSNHQS | ILDMMGLMEV | LPERCVQIAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RELLFLGPVG | LIMYLGGVFF | INRQRSSTAM | TVMADLGERM | VRENLKVWIY | PEGTRNDNGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLPFKKGAFY | LAVQAQVPIV | PVVYSSFSSF | YNTKKKFFTS | GTVTVQVLEA | IPTSGLTAAD |
| 250 | 260 | 270 | |||
| VPALVDTCHR | AMRTTFLHIS | KTPQENGATA | GSGVQPAQ |