Q8GXU8
Gene name |
LPAT1 |
Protein name |
1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic |
Names |
Lysophosphatidyl acyltransferase 1, Protein EMBRYO DEFECTIVE 1995 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G30580 |
EC number |
2.3.1.51: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GXU8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GXU8-F1 | Predicted | AlphaFoldDB |
16 variants for Q8GXU8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02944859 | 46 | T>K | No | 1000Genomes | |
| ENSVATH00545584 | 47 | S>N | No | 1000Genomes | |
| tmp_4_14933969_T_A | 53 | H>L | No | 1000Genomes | |
| tmp_4_14933692_T_C | 65 | R>G | No | 1000Genomes | |
| tmp_4_14933640_C_G | 82 | R>T | No | 1000Genomes | |
| tmp_4_14933632_C_A | 85 | D>Y | No | 1000Genomes | |
| ENSVATH00545583 | 87 | K>Q | No | 1000Genomes | |
| ENSVATH08371651 | 101 | R>K | No | 1000Genomes | |
| ENSVATH12319447 | 104 | L>F | No | 1000Genomes | |
| tmp_4_14933293_G_A | 154 | L>F | No | 1000Genomes | |
| ENSVATH06803893 | 158 | Y>C | No | 1000Genomes | |
| ENSVATH06803891 | 182 | N>S | No | 1000Genomes | |
| ENSVATH00545581 | 327 | R>K | No | 1000Genomes | |
| tmp_4_14932570_G_A | 339 | A>V | No | 1000Genomes | |
| tmp_4_14932523_C_T | 355 | D>N | No | 1000Genomes | |
| ENSVATH02944853 | 356 | L>F | No | 1000Genomes |
No associated diseases with Q8GXU8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.51 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast membrane | Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
| phosphatidylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33333 | SLC1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q95JH2 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Bos taurus (Bovine) | PR |
| Q99943 | AGPAT1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Homo sapiens (Human) | PR |
| O15120 | AGPAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Homo sapiens (Human) | PR |
| Q8K3K7 | Agpat2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta | Mus musculus (Mouse) | PR |
| Q9LLY4 | BAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase BAT2, chloroplastic | Brassica napus (Rape) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDVASARSIS | SHPSYYGKPI | CSSQSSLIRI | SRDKVCCFGR | ISNGMTSFTT | SLHAVPSEKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MGETRRTGIQ | WSNRSLRHDP | YRFLDKKSPR | SSQLARDITV | RADLSGAATP | DSSFPEPEIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSSRLRGIFF | CVVAGISATF | LIVLMIIGHP | FVLLFDPYRR | KFHHFIAKLW | ASISIYPFYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INIEGLENLP | SSDTPAVYVS | NHQSFLDIYT | LLSLGKSFKF | ISKTGIFVIP | IIGWAMSMMG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVPLKRMDPR | SQVDCLKRCM | ELLKKGASVF | FFPEGTRSKD | GRLGSFKKGA | FTVAAKTGVA |
| 310 | 320 | 330 | 340 | 350 | |
| VVPITLMGTG | KIMPTGSEGI | LNHGNVRVII | HKPIHGSKAD | VLCNEARSKI | AESMDL |