Q94BV7

PR
Gene name
NDB2 (At4g05020, T32N4.4)
Protein name
External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial
Names
External alternative NADH dehydrogenase NDB2, NADH:ubiquinone reductase (non-electrogenic) NDB2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G05020
EC number
1.6.5.9: With a quinone or similar compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94BV7

Entry ID Method Resolution Chain Position Source
AF-Q94BV7-F1 Predicted AlphaFoldDB

23 variants for Q94BV7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00465549 6 V>A No 1000Genomes
tmp_4_2572810_T_A 20 L>H No 1000Genomes
ENSVATH00465550 23 I>T No 1000Genomes
ENSVATH10762559 50 A>D No 1000Genomes
ENSVATH13945470 51 V>I No 1000Genomes
ENSVATH02664720 57 K>R No 1000Genomes
ENSVATH06479318 60 K>R No 1000Genomes
tmp_4_2573347_C_G 69 A>G No 1000Genomes
tmp_4_2573655_C_A 140 S>R No 1000Genomes
tmp_4_2573687_T_A 151 L>H No 1000Genomes
ENSVATH00465566 151 L>I No 1000Genomes
ENSVATH13945473 156 K>N No 1000Genomes
ENSVATH08231343 160 S>F No 1000Genomes
ENSVATH02664748 216 D>N No 1000Genomes
tmp_4_2574031_A_T 217 E>V No 1000Genomes
ENSVATH10762600 226 V>L No 1000Genomes
ENSVATH06479354 313 K>R No 1000Genomes
tmp_4_2574916_A_C 406 E>D No 1000Genomes
ENSVATH10762662 441 D>N No 1000Genomes
ENSVATH10762705 488 R>S No 1000Genomes
ENSVATH00465589 490 E>V No 1000Genomes
tmp_4_2575328_C_T 511 R>C No 1000Genomes
tmp_4_2576184_A_G 571 R>G No 1000Genomes

No associated diseases with Q94BV7

3 regional properties for Q94BV7

Type Name Position InterPro Accession
domain EF-hand domain 379 - 414 IPR002048
binding_site EF-Hand 1, calcium-binding site 392 - 404 IPR018247
domain FAD/NAD(P)-binding domain 59 - 384 IPR023753

Functions

Description
EC Number 1.6.5.9 With a quinone or similar compound as acceptor
Subcellular Localization
  • Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
NADH oxidation A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32340 NDI1 Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q07500 NDE2 External NADH-ubiquinone oxidoreductase 2, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40215 NDE1 External NADH-ubiquinone oxidoreductase 1, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
M1BYJ7 NDB1 External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial Solanum tuberosum (Potato) PR
F4JJJ3 NDB3 External alternative NAD(P)H-ubiquinone oxidoreductase B3, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q1JPL4 NDB1 External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q8GWA1 NDA1 Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRNFSVFERF SKAFKDHPSL TRILVVSTIS GGGLIAYSEA NASYGANGGA VVETGTKKKK
70 80 90 100 110 120
VVLLGTGWAG TSFLKNLNNS QYEVQIISPR NYFAFTPLLP SVTCGTVEAR SVVEPIRNIG
130 140 150 160 170 180
RKNVDTSYLE AECFKIDPAS KKVYCRSKQG LSSNGKKEFS VDYDYLVIAT GAQSNTFNIP
190 200 210 220 230 240
GVEENCHFLK EVEDAQRIRK TVIDSFEKAS LPELSDEERK RILHFVVVGG GPTGVEFAAE
250 260 270 280 290 300
LHDFVTEDLV SLYPRAKGSV RITLLEAADH ILTMFDKRIT EFAEEKFSRD GIDVKLGSMV
310 320 330 340 350 360
TKVNEKDISA KTKGGEVSSI PYGMIVWSTG IGTRPVIKDF MKQIGQGNRR ALATDEWLRV
370 380 390 400 410 420
EGTDNIYALG DCATINQRKV MEDVSAIFSK ADKDKSGTLT LKEFQEAMDD ICVRYPQVEL
430 440 450 460 470 480
YLKSKRMRGI ADLLKEAETD DVSKNNIELK IEEFKSALSQ VDSQVKFLPA TAQVAAQQGA
490 500 510 520 530 540
YLAKCFDRME ECEKSPEGPI RMRGEGRHRF RPFRYRHLGQ FAPLGGEQTA AQLPGDWVSI
550 560 570 580
GHSSQWLWYS VYASKQVSWR TRVLVVSDWM RRFIFGRDSS SI