Q07500
Gene name |
NDE2 (NDH2, YDL085W) |
Protein name |
External NADH-ubiquinone oxidoreductase 2, mitochondrial |
Names |
External NADH dehydrogenase 2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL085W |
EC number |
1.6.5.9: With a quinone or similar compound as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q07500
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q07500-F1 | Predicted | AlphaFoldDB |
6 variants for Q07500
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-303260 | 17 | F>C | No | SGRP | |
| s04-303361 | 51 | K>E | No | SGRP | |
| s04-303478 | 90 | A>T | No | SGRP | |
| s04-303806 | 199 | S>N | No | SGRP | |
| s04-304549 | 447 | D>Y | No | SGRP | |
| s04-304554 | 448 | M>I | No | SGRP |
No associated diseases with Q07500
1 regional properties for Q07500
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FAD/NAD(P)-binding domain | 99 - 428 | IPR023753 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.6.5.9 | With a quinone or similar compound as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| NADH dehydrogenase (quinone) activity | Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. |
| NADH dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycolytic fermentation to ethanol | The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. |
| NADH oxidation | A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32340 | NDI1 | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P40215 | NDE1 | External NADH-ubiquinone oxidoreductase 1, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| M1BYJ7 | NDB1 | External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial | Solanum tuberosum (Potato) | PR |
| Q9ST62 | NDB1 | External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial | Solanum tuberosum (Potato) | PR |
| F4JJJ3 | NDB3 | External alternative NAD(P)H-ubiquinone oxidoreductase B3, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94BV7 | NDB2 | External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1JPL4 | NDB1 | External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLPRLGFART | ARSIHRFKMT | QISKPFFHST | EVGKPGPQQK | LSKSYTAVFK | KWFVRGLKLT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FYTTLAGTLY | VSYELYKESN | PPKQVPQSTA | FANGLKKKEL | VILGTGWGAI | SLLKKLDTSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YNVTVVSPRS | FFLFTPLLPS | TPVGTIEMKS | IVEPVRSIAR | RTPGEVHYIE | AEALDVDPKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKVMVQSVSE | DEYFVSSLSY | DYLVVSVGAK | TTTFNIPGVY | GNANFLKEIE | DAQNIRMKLM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KTIEQASSFP | VNDPERKRLL | TFVVVGGGPT | GVEFAAELQD | YINQDLRKWM | PDLSKEMKVI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIEALPNILN | MFDKTLIKYA | EDLFARDEID | LQVNTAVKVV | EPTYIRTLQN | GQTNTDIEYG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MLVWATGNEP | IDFSKTLMSR | IPEQTNRRGL | LINDKLELLG | SENSIYAIGD | CTAHTGFFPT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AQVAHQEGEY | LAKILDKKLQ | IEQLEWDMLN | STDETEVSRL | QKEVNLRKSK | LDKFNYKHMG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALAYIGSETA | IADLHMGDSS | YQLKGMFAFL | FWKSAYLAMC | LSIRNRILIA | MDWTKVYFLG |
| RDSSV |