AiPD: Autoinhibited Protein Database

Gene name	NDB1 (At4g28220, F26K10.100)
Protein name	External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial
Names	External alternative NADH dehydrogenase NDB1, NADH:ubiquinone reductase (non-electrogenic) NDB1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G28220
EC number	1.6.5.9: With a quinone or similar compound as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-82 (Predicted disordered autoinhibitory region) PR

1-82 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q1JPL4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH06789565	8	G>R	No	1000Genomes
ENSVATH06789566	15	P>T	No	1000Genomes
ENSVATH00542439	17	A>D	No	1000Genomes
tmp_4_13993436_G_A	32	V>M	No	1000Genomes
tmp_4_13993440_C_T	33	A>V	No	1000Genomes
ENSVATH06789572	34	Y>C	No	1000Genomes
ENSVATH00542441	39	E>A	No	1000Genomes
tmp_4_13993459_A_C	39	E>D	No	1000Genomes
ENSVATH00542444	67	D>N	No	1000Genomes
tmp_4_13993583_C_A	81	Q>K	No	1000Genomes
tmp_4_13993584_A_C	81	Q>P	No	1000Genomes
tmp_4_13993819_A_G	129	D>G	No	1000Genomes
tmp_4_13993942_G_A	170	G>D	No	1000Genomes
ENSVATH00542449	175	L>I	No	1000Genomes
ENSVATH12273533	214	K>N	No	1000Genomes
ENSVATH06789576	289	G>E	No	1000Genomes
ENSVATH06789577	293	M>L	No	1000Genomes
ENSVATH06789578	302	V>M	No	1000Genomes
ENSVATH00542452	312	S>R	No	1000Genomes
tmp_4_13994571_G_A	324	V>I	No	1000Genomes
ENSVATH00542454	386	A>V	No	1000Genomes
tmp_4_13994865_C_T	391	T>I	No	1000Genomes
ENSVATH12273606	406	V>L	No	1000Genomes
ENSVATH14305293	411	V>M	No	1000Genomes
ENSVATH06789583	417	S>T	No	1000Genomes
tmp_4_13995029_G_A	446	A>T	No	1000Genomes
ENSVATH00542456	472	A>S	No	1000Genomes
ENSVATH06789588	518	A>E	No	1000Genomes
ENSVATH02934509	540	V>I	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	EF-hand domain	372 - 407	IPR002048
binding_site	EF-Hand 1, calcium-binding site	385 - 397	IPR018247
domain	FAD/NAD(P)-binding domain	50 - 369	IPR023753

		Description
EC Number	1.6.5.9	With a quinone or similar compound as acceptor
Subcellular Localization	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extrinsic component of mitochondrial inner membrane	The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrial intermembrane space	The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
NADH dehydrogenase (quinone) activity	Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
NADPH dehydrogenase activity	Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Name	Definition
NADH oxidation	A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
NADPH oxidation	A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32340	NDI1	Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q07500	NDE2	External NADH-ubiquinone oxidoreductase 2, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P40215	NDE1	External NADH-ubiquinone oxidoreductase 1, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
M1BYJ7	NDB1	External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial	Solanum tuberosum (Potato)	PR
Q9ST62	NDB1	External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial	Solanum tuberosum (Potato)	PR
F4JJJ3	NDB3	External alternative NAD(P)H-ubiquinone oxidoreductase B3, mitochondrial	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GWA1	NDA1	Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94BV7	NDB2	External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial	Arabidopsis thaliana (Mouse-ear cress)	PR