P40215
Gene name |
NDE1 (NDH1, YMR145C, YM9375.14C) |
Protein name |
External NADH-ubiquinone oxidoreductase 1, mitochondrial |
Names |
External NADH dehydrogenase 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR145C |
EC number |
1.6.5.9: With a quinone or similar compound as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P40215
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P40215-F1 | Predicted | AlphaFoldDB |
1 variants for P40215
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-555078 | 466 | A>V | No | SGRP |
No associated diseases with P40215
No regional properties for P40215
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P40215 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.6.5.9 | With a quinone or similar compound as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| NADH dehydrogenase (quinone) activity | Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. |
| NADH dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| glycolytic fermentation to ethanol | The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. |
| NADH oxidation | A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32340 | NDI1 | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q07500 | NDE2 | External NADH-ubiquinone oxidoreductase 2, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| M1BYJ7 | NDB1 | External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial | Solanum tuberosum (Potato) | PR |
| Q9ST62 | NDB1 | External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial | Solanum tuberosum (Potato) | PR |
| F4JJJ3 | NDB3 | External alternative NAD(P)H-ubiquinone oxidoreductase B3, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94BV7 | NDB2 | External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1JPL4 | NDB1 | External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIRQSLMKTV | WANSSRFSLQ | SKSGLVKYAK | NRSFHAARNL | LEDKKVILQK | VAPTTGVVAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSFFKRTGKF | TLKALLYSAL | AGTAYVSYSL | YREANPSTQV | PQSDTFPNGS | KRKTLVILGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GWGSVSLLKN | LDTTLYNVVV | VSPRNYFLFT | PLLPSTPVGT | IELKSIVEPV | RTIARRSHGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VHYYEAEAYD | VDPENKTIKV | KSSAKNNDYD | LDLKYDYLVV | GVGAQPNTFG | TPGVYEYSSF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKEISDAQEI | RLKIMSSIEK | AASLSPKDPE | RARLLSFVVV | GGGPTGVEFA | AELRDYVDQD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRKWMPELSK | EIKVTLVEAL | PNILNMFDKY | LVDYAQDLFK | EEKIDLRLKT | MVKKVDATTI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TAKTGDGDIE | NIPYGVLVWA | TGNAPREVSK | NLMTKLEEQD | SRRGLLIDNK | LQLLGAKGSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FAIGDCTFHP | GLFPTAQVAH | QEGEYLAQYF | KKAYKIDQLN | WKMTHAKDDS | EVARLKNQIV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KTQSQIEDFK | YNHKGALAYI | GSDKAIADLA | VGEAKYRLAG | SFTFLFWKSA | YLAMCLSFRN |
| 550 | |||||
| RVLVAMDWAK | VYFLGRDSSI |