Q8GWA1

PR
Gene name
NDA1 (NDI1, At1g07180, F10K1.11)
Protein name
Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial
Names
Internal alternative NADH dehydrogenase NDA1, Internal non-phosphorylating NAD(P)H dehydrogenase 1, AtNDI1, NADH:ubiquinone reductase (non-electrogenic) NDA1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G07180
EC number
1.6.5.9: With a quinone or similar compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-98 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GWA1

Entry ID Method Resolution Chain Position Source
AF-Q8GWA1-F1 Predicted AlphaFoldDB

21 variants for Q8GWA1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00009783 2 L>F No 1000Genomes
tmp_1_2204486_C_A 25 P>T No 1000Genomes
ENSVATH01020549 45 D>E No 1000Genomes
ENSVATH01020550 46 T>A No 1000Genomes
tmp_1_2204552_G_T 47 V>F No 1000Genomes
ENSVATH01020551 55 N>H No 1000Genomes
ENSVATH10724935 69 K>I No 1000Genomes
tmp_1_2204697_G_C 95 S>T No 1000Genomes
tmp_1_2204700_T_C 96 I>T No 1000Genomes
ENSVATH00009785 158 N>K No 1000Genomes
ENSVATH04533169 175 P>A No 1000Genomes
ENSVATH04533170 176 W>R No 1000Genomes
ENSVATH13859955 206 I>V No 1000Genomes
ENSVATH04533171 236 D>G No 1000Genomes
tmp_1_2205503_A_C 239 K>Q No 1000Genomes
ENSVATH04533172 304 Q>L No 1000Genomes
ENSVATH00009787 337 P>L No 1000Genomes
ENSVATH10724937 367 E>D No 1000Genomes
ENSVATH00009789 388 E>V No 1000Genomes
tmp_1_2206750_G_A 504 G>S No 1000Genomes
tmp_1_2206763_G_A 508 S>N No 1000Genomes

No associated diseases with Q8GWA1

1 regional properties for Q8GWA1

Type Name Position InterPro Accession
domain FAD/NAD(P)-binding domain 75 - 406 IPR023753

Functions

Description
EC Number 1.6.5.9 With a quinone or similar compound as acceptor
Subcellular Localization
  • Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
intrinsic component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

4 GO annotations of molecular function

Name Definition
NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
NADPH dehydrogenase activity Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
cellular response to light stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
NADH oxidation A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
M1BYJ7 NDB1 External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial Solanum tuberosum (Potato) PR
F4JJJ3 NDB3 External alternative NAD(P)H-ubiquinone oxidoreductase B3, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q1JPL4 NDB1 External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q94BV7 NDB2 External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLWIKNLARI SQTTSSSVGN VFRNPESYTL SSRFCTALQK QQVTDTVQAK EDVVNALEPQ
70 80 90 100 110 120
RYDGLAPTKE GEKPRVLVLG SGWAGCRVLK GIDTSIYDVV CVSPRNHMVF TPLLASTCVG
130 140 150 160 170 180
TLEFRSVAEP ISRIQPAISR EPGSYYFLAN CSKLDADNHE VHCETVTEGS STLKPWKFKI
190 200 210 220 230 240
AYDKLVLACG AEASTFGING VLENAIFLRE VHHAQEIRRK LLLNLMLSEV PGIGEDEKKR
250 260 270 280 290 300
LLHCVVVGGG PTGVEFSGEL SDFIMKDVRQ RYSHVKDDIR VTLIEARDIL SSFDDRLRHY
310 320 330 340 350 360
AIKQLNKSGV KLVRGIVKEV KPQKLILDDG TEVPYGPLVW STGVGPSSFV RSLDFPKDPG
370 380 390 400 410 420
GRIGIDEWMR VPSVQDVFAI GDCSGYLEST GKSTLPALAQ VAEREGKYLA NLFNVMGKAG
430 440 450 460 470 480
GGRANSAKEM ELGEPFVYKH LGSMATIGRY KALVDLRESK EGKGISMAGF LSWFIWRSAY
490 500
LTRVVSWRNR FYVAINWLTT FVFGRDISRI