Q94518

PR
Gene name
Nacalpha (aic, CG8759)
Protein name
Nascent polypeptide-associated complex subunit alpha
Names
NAC-alpha, Alpha-NAC
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG8759
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94518

Entry ID Method Resolution Chain Position Source
AF-Q94518-F1 Predicted AlphaFoldDB

No variants for Q94518

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q94518

No associated diseases with Q94518

2 regional properties for Q94518

Type Name Position InterPro Accession
domain Nascent polypeptide-associated complex NAC domain 70 - 135 IPR002715
domain Nascent polypeptide-associated complex subunit alpha-like, UBA domain 176 - 215 IPR044034

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nascent polypeptide-associated complex A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.

1 GO annotations of molecular function

Name Definition
unfolded protein binding Binding to an unfolded protein.

1 GO annotations of biological process

Name Definition
protein targeting to membrane The process of directing proteins towards a membrane, usually using signals contained within the protein.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9A1 NACA Nascent polypeptide-associated complex subunit alpha Bos taurus (Bovine) PR
Q13765 NACA Nascent polypeptide-associated complex subunit alpha Homo sapiens (Human) PR
Q9BZK3 NACA4P Putative nascent polypeptide-associated complex subunit alpha-like protein Homo sapiens (Human) PR
Q86S66 icd-2 Nascent polypeptide-associated complex subunit alpha Caenorhabditis elegans PR
Q94JX9 At3g49470 Nascent polypeptide-associated complex subunit alpha-like protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q68F90 naca Nascent polypeptide-associated complex subunit alpha Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MPELTEIKSE AAPSTSAEAK PEDVRVEDDG SDSDSDGGMP GLEEAVAATT QLGGGATGLP
70 80 90 100 110 120
IDLVSKAKQS RGEKKARKIM LKLGLKQIQG VNRVTIRKSK NILFVINNPD VYKNPHSDTY
130 140 150 160 170 180
IVFGEAKIED LSQQAQVAAA EKFKAPEAAG AADSVGATTS VAPIAEEDEE DVDDTGVDEK
190 200 210
DIELVITQAN TTRAKAIKAL KNNNNDIVNA IMELTML