Q86S66
Gene name |
icd-2 |
Protein name |
Nascent polypeptide-associated complex subunit alpha |
Names |
NAC-alpha, Alpha-NAC, Inhibitor of cell death 2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_Y65B4BR.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q86S66
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q86S66-F1 | Predicted | AlphaFoldDB |
No variants for Q86S66
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q86S66 | |||||
No associated diseases with Q86S66
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nascent polypeptide-associated complex | A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| unfolded protein binding | Binding to an unfolded protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of protein localization to endoplasmic reticulum | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum. |
| protein targeting to membrane | The process of directing proteins towards a membrane, usually using signals contained within the protein. |
| regulation of cellular response to heat | Any process that modulates the frequency, rate or extent of cellular response to heat. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9A1 | NACA | Nascent polypeptide-associated complex subunit alpha | Bos taurus (Bovine) | PR |
| Q94518 | Nacalpha | Nascent polypeptide-associated complex subunit alpha | Drosophila melanogaster (Fruit fly) | PR |
| Q13765 | NACA | Nascent polypeptide-associated complex subunit alpha | Homo sapiens (Human) | PR |
| Q9BZK3 | NACA4P | Putative nascent polypeptide-associated complex subunit alpha-like protein | Homo sapiens (Human) | PR |
| Q94JX9 | At3g49470 | Nascent polypeptide-associated complex subunit alpha-like protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q68F90 | naca | Nascent polypeptide-associated complex subunit alpha | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGSTETRQK | EVKEPQVDVS | DDSDNEAVEQ | ELTEEQRRVA | EAAGLGDHID | KQAKQSRSEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KARKLFSKLG | LKQVTGVSRV | CIRKSKNILF | VINKPDVFKS | PGSDTYIIFG | EAKIEDLTQH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQMSAIENLK | PTREAPQLKT | VEEDENEDVE | EDSTGIEEKD | IELVISQANT | TRNKAIRALK |
| 190 | |||||
| EADNDIVNAI | MSLTM |