AiPD: Autoinhibited Protein Database

Gene name	NACA
Protein name	Nascent polypeptide-associated complex subunit alpha
Names	NAC-alpha, Alpha-NAC
Species	Bos taurus (Bovine)
KEGG Pathway	bta:513312
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-103 (Predicted disordered autoinhibitory region) PR

1-103 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5E9A1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs482490953	4	E>D	No	EVA
rs446379139	7	D>A	No	EVA
rs457624228	8	T>P	No	EVA
rs479463898	9	V>A	No	EVA
rs479463898	9	V>D	No	EVA
rs468286662	11	A>V	No	EVA
rs450570461	12	T>K	No	EVA
rs435283281	12	T>P	No	EVA
rs433006098	13	E>G	No	EVA
rs451498164	15	E>G	No	EVA
rs473331750	16	L>M	No	EVA
rs434767097	18	Q>P	No	EVA
rs453274040	19	P>A	No	EVA
rs480146646	35	V>I	No	EVA
rs450568607	50	Q>H	No	EVA
rs462702702	54	A>S	No	EVA
rs478052106	55	A>S	No	EVA
rs478935667	56	A>E	No	EVA
rs478935667	56	A>G	No	EVA
rs460386920	56	A>S	No	EVA
rs466912760	74	K>*	No	EVA
rs435641201	75	K>Q	No	EVA
rs478309203	79	A>S	No	EVA
rs445329744	80	M>I	No	EVA
rs466948684	81	S>A	No	EVA
rs479003632	81	S>F	No	EVA
rs449428559	85	L>H	No	EVA
rs467885485	86	R>*	No	EVA
rs438306120	86	R>Q	No	EVA
rs464977098	87	Q>R	No	EVA
rs432018340	91	V>A	No	EVA
rs453825064	92	T>N	No	EVA
rs472329842	93	R>T	No	EVA
rs442631462	96	I>S	No	EVA
rs454741729	98	K>*	No	EVA
rs443519979	101	N>K	No	EVA
rs462860232	102	I>F	No	EVA
rs471806693	105	V>F	No	EVA
rs438823450	106	I>S	No	EVA
rs460461070	108	K>Q	No	EVA
rs478940505	110	D>N	No	EVA
rs449367290	115	P>R	No	EVA
rs461395786	125	E>Q	No	EVA
rs442888728	132	S>Y	No	EVA
rs461462532	142	K>N	No	EVA
rs483240692	144	K>R	No	EVA
rs450243277	146	Q>H	No	EVA
rs459231411	149	A>T	No	EVA
rs477788333	156	N>D	No	EVA
rs449261043	171	V>I	No	EVA
rs448180156	207	V>G	No	EVA

Type	Name	Position	InterPro Accession
domain	Nascent polypeptide-associated complex NAC domain	70 - 135	IPR002715
domain	Nascent polypeptide-associated complex subunit alpha-like, UBA domain	176 - 214	IPR044034

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nascent polypeptide-associated complex	A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
unfolded protein binding	Binding to an unfolded protein.

Name	Definition
protein targeting to membrane	The process of directing proteins towards a membrane, usually using signals contained within the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q94518	Nacalpha	Nascent polypeptide-associated complex subunit alpha	Drosophila melanogaster (Fruit fly)	PR
Q13765	NACA	Nascent polypeptide-associated complex subunit alpha	Homo sapiens (Human)	PR
Q9BZK3	NACA4P	Putative nascent polypeptide-associated complex subunit alpha-like protein	Homo sapiens (Human)	PR
Q86S66	icd-2	Nascent polypeptide-associated complex subunit alpha	Caenorhabditis elegans	PR
Q94JX9	At3g49470	Nascent polypeptide-associated complex subunit alpha-like protein 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q68F90	naca	Nascent polypeptide-associated complex subunit alpha	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR