Q68F90
Gene name |
naca |
Protein name |
Nascent polypeptide-associated complex subunit alpha |
Names |
NAC-alpha, Alpha-NAC |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:493239 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q68F90
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q68F90-F1 | Predicted | AlphaFoldDB |
No variants for Q68F90
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q68F90 | |||||
No associated diseases with Q68F90
17 regional properties for Q68F90
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NGN domain | 183 - 265 | IPR005100 |
| domain | KOW | 273 - 300 | IPR005824-1 |
| domain | KOW | 425 - 452 | IPR005824-2 |
| domain | KOW | 477 - 522 | IPR005824-3 |
| domain | KOW | 601 - 628 | IPR005824-4 |
| domain | KOW | 712 - 739 | IPR005824-5 |
| domain | KOW | 988 - 1015 | IPR005824-6 |
| conserved_site | Ribosomal protein L24/L26, conserved site | 429 - 446 | IPR005825 |
| domain | NusG-like, N-terminal | 181 - 268 | IPR006645 |
| domain | Spt5 transcription elongation factor, N-terminal | 90 - 177 | IPR022581 |
| domain | NGN domain, eukaryotic | 183 - 266 | IPR039385 |
| domain | Spt5, KOW domain repeat 1 | 277 - 314 | IPR041973 |
| domain | Spt5, KOW domain repeat 2 | 426 - 476 | IPR041975 |
| domain | Spt5, KOW domain repeat 3 | 477 - 527 | IPR041976 |
| domain | Spt5, KOW domain repeat 4 | 605 - 647 | IPR041977 |
| domain | Spt5, KOW domain repeat 5 | 711 - 758 | IPR041978 |
| domain | Spt5, KOW domain repeat 6 | 982 - 1039 | IPR041980 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nascent polypeptide-associated complex | A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| unfolded protein binding | Binding to an unfolded protein. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein targeting to membrane | The process of directing proteins towards a membrane, usually using signals contained within the protein. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9A1 | NACA | Nascent polypeptide-associated complex subunit alpha | Bos taurus (Bovine) | PR |
| Q94518 | Nacalpha | Nascent polypeptide-associated complex subunit alpha | Drosophila melanogaster (Fruit fly) | PR |
| Q13765 | NACA | Nascent polypeptide-associated complex subunit alpha | Homo sapiens (Human) | PR |
| Q9BZK3 | NACA4P | Putative nascent polypeptide-associated complex subunit alpha-like protein | Homo sapiens (Human) | PR |
| Q86S66 | icd-2 | Nascent polypeptide-associated complex subunit alpha | Caenorhabditis elegans | PR |
| Q94JX9 | At3g49470 | Nascent polypeptide-associated complex subunit alpha-like protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGEATETVP | AAEQELHQPQ | AETGSGTESD | SDDSPPELEQ | DSTQTTTQQA | QLAAAAEIDE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPVSKAKQSR | SEKKARKAMS | KLGLRQVTGV | TRVTIRKSKN | ILFVITKPDV | YKSPASDTYI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFGEAKIEDL | SQQAQLAAAE | KFKVQGEAVS | NIQENTQTPT | VQEESEEEEV | DETGVEVKDI |
| 190 | 200 | 210 | |||
| ELVMSQANVS | RAKAVRALKN | NSNDIVNAIM | ELTM |