Q91Z69
PR
Gene name |
Srgap1 (Arhgap13) |
Protein name |
SLIT-ROBO Rho GTPase-activating protein 1 |
Names |
srGAP1, Rho GTPase-activating protein 13 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:117600 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q91Z69
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2GNC | X-ray | 180 A | A/B | 725-776 | PDB |
| AF-Q91Z69-F1 | Predicted | AlphaFoldDB |
63 variants for Q91Z69
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389131903 | 23 | E>G | No | EVA | |
| rs3389131941 | 44 | Q>* | No | EVA | |
| rs3389140767 | 46 | L>F | No | EVA | |
| rs3389102051 | 50 | Q>H | No | EVA | |
| rs3401371171 | 62 | E>A | No | EVA | |
| rs3401777991 | 62 | E>D | No | EVA | |
| rs3389140792 | 85 | Q>H | No | EVA | |
| rs3389128105 | 109 | R>G | No | EVA | |
| rs3389139894 | 157 | V>D | No | EVA | |
| rs3401724214 | 199 | P>S | No | EVA | |
| rs3401729255 | 203 | I>L | No | EVA | |
| rs3401626475 | 204 | R>M | No | EVA | |
| rs3401870612 | 204 | R>S | No | EVA | |
| rs47231761 | 273 | Y>F | No | EVA | |
| rs3389122835 | 304 | N>I | No | EVA | |
| rs3389131935 | 310 | E>D | No | EVA | |
| rs3389107529 | 314 | D>E | No | EVA | |
| rs3389095059 | 333 | E>K | No | EVA | |
| rs3389130907 | 349 | Q>H | No | EVA | |
| rs3389130882 | 356 | M>I | No | EVA | |
| rs3389139963 | 393 | I>N | No | EVA | |
| rs3389132670 | 404 | H>N | No | EVA | |
| rs3389128254 | 404 | H>R | No | EVA | |
| rs3389140826 | 407 | S>A | No | EVA | |
| rs3389095083 | 442 | K>E | No | EVA | |
| rs3389069592 | 470 | G>V | No | EVA | |
| rs3389128069 | 481 | G>E | No | EVA | |
| rs3389095090 | 494 | Q>H | No | EVA | |
| rs3389122908 | 500 | V>M | No | EVA | |
| rs3389140805 | 509 | L>I | No | EVA | |
| rs3389117070 | 509 | L>P | No | EVA | |
| rs3389126481 | 521 | S>C | No | EVA | |
| rs3389122877 | 522 | G>D | No | EVA | |
| rs3389126473 | 524 | Q>L | No | EVA | |
| rs3389126473 | 524 | Q>R | No | EVA | |
| rs3389130863 | 551 | N>K | No | EVA | |
| rs3389130873 | 553 | V>L | No | EVA | |
| rs3401110291 | 571 | K>* | No | EVA | |
| rs3389128293 | 590 | A>T | No | EVA | |
| rs3389095117 | 616 | N>S | No | EVA | |
| rs3389117100 | 638 | P>L | No | EVA | |
| rs3389140802 | 659 | I>N | No | EVA | |
| rs3389134292 | 660 | V>E | No | EVA | |
| rs3389069604 | 686 | M>T | No | EVA | |
| rs3389122906 | 690 | D>G | No | EVA | |
| rs3389095115 | 691 | Y>H | No | EVA | |
| rs3389128128 | 698 | E>* | No | EVA | |
| rs252890342 | 707 | Q>H | No | EVA | |
| rs3389095079 | 714 | H>Q | No | EVA | |
| rs3389102078 | 792 | D>N | No | EVA | |
| rs3401706152 | 829 | G>R | No | EVA | |
| rs3401985357 | 865 | N>S | No | EVA | |
| rs46546576 | 880 | N>K | No | EVA | |
| rs3389132727 | 949 | E>D | No | EVA | |
| rs3389117089 | 958 | T>I | No | EVA | |
| rs247979974 | 962 | A>T | No | EVA | |
| rs3389122839 | 975 | N>I | No | EVA | |
| rs3401777404 | 1001 | I>F | No | EVA | |
| rs3401720971 | 1001 | I>T | No | EVA | |
| rs3389117085 | 1010 | E>K | No | EVA | |
| rs3389130898 | 1022 | R>L | No | EVA | |
| rs3389128277 | 1024 | G>S | No | EVA | |
| rs3401720985 | 1053 | Q>* | No | EVA |
No associated diseases with Q91Z69
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| small GTPase binding | Binding to a small monomeric GTPase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| Rho protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5T0N5 | FNBP1L | Formin-binding protein 1-like | Homo sapiens (Human) | PR |
| O94868 | FCHSD2 | F-BAR and double SH3 domains protein 2 | Homo sapiens (Human) | PR |
| Q96RU3 | FNBP1 | Formin-binding protein 1 | Homo sapiens (Human) | PR |
| O75044 | SRGAP2 | SLIT-ROBO Rho GTPase-activating protein 2 | Homo sapiens (Human) | PR |
| Q7Z6B7 | SRGAP1 | SLIT-ROBO Rho GTPase-activating protein 1 | Homo sapiens (Human) | PR |
| Q8CJ53 | Trip10 | Cdc42-interacting protein 4 | Mus musculus (Mouse) | PR |
| Q3USJ8 | Fchsd2 | F-BAR and double SH3 domains protein 2 | Mus musculus (Mouse) | PR |
| Q6PFY1 | Fchsd1 | F-BAR and double SH3 domains protein 1 | Mus musculus (Mouse) | PR |
| Q80TY0 | Fnbp1 | Formin-binding protein 1 | Mus musculus (Mouse) | PR |
| Q8K012 | Fnbp1l | Formin-binding protein 1-like | Mus musculus (Mouse) | PR |
| Q91Z67 | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2 | Mus musculus (Mouse) | PR |
| Q812A2 | Srgap3 | SLIT-ROBO Rho GTPase-activating protein 3 | Mus musculus (Mouse) | PR |
| Q8R511 | Fnbp1 | Formin-binding protein 1 | Rattus norvegicus (Rat) | PR |
| Q2HWF0 | Fnbp1l | Formin-binding protein 1-like | Rattus norvegicus (Rat) | PR |
| D4A208 | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTPSRFKKD | KEIIAEYESQ | VKEIRAQLVE | QQKCLEQQTE | MRVQLLQDLQ | DFFRKKAEIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEYSRNLEKL | AERFMAKTRS | TKDHQQFKKD | QNLLSPVNCW | YLLLNQVRRE | SKDHATLSDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLNNVIMRFM | QISEDSTRMF | KKSKEIAFQL | HEDLMKVLNE | LYTVMKTYHM | YHSESISAES |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLKEAEKQEE | KQIGRSGDPV | FHIRLEERHQ | RRSSVKKIEK | MKEKRQAKYS | ENKLKSIKAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NEYLLTLEAT | NASVFKYYIH | DLSDLIDCCD | LGYHASLNRA | LRTYLSAEYN | LETSRHEGLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IIENAVDNLE | PRSDKQRFME | MYPAAFCPPM | KFEFQSHMGD | EVCQVSAQQP | VQAELMLRNQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLQSRLATLK | IESEEVKKTT | EATLQTIQDM | VTIEDYDVSE | CFQHSRSTES | VKSTVSETYL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SKPSIAKRRA | NQQETEQFYF | MKLREFLEGS | NLITKLQAKH | DLLQRTLGEG | HRAEYMTTSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GRRNSHARHQ | DSGQVIPLIV | ESCIRFINLY | GLQHQGIFRV | SGSQVEVNDI | KNSFERGENP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LSDEQSNHDI | NSVAGVLKLY | FRGLENPLFP | KERFTDLISC | IRIDNLYERA | LHIRKLLLTL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PRSVLIVMRY | LFAFLNHLSQ | YSDENMMDPY | NLAICFGPTL | MPVPEIQDQV | SCQAHVNEIV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KTIIIHHETI | FPDAKELDGP | VYEKCMAGGD | YCDSPYSEHG | TLEEVDQDAG | TEPHTSEDEC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EPIEAIAKFD | YVGRSARELS | FKKGASLLLY | HRASEDWWEG | RHNGIDGLVP | HQYIVVQDMD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DTFSDTLSQK | ADSEASSGPV | TEDKSSSKDM | NSPTDRHSDS | YLARQRKRGE | PPPPGRRPGR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TSDGHCPLHP | PHALSNSSID | LGSPNLASHP | RGLLQNRGLN | NDSPERRRRP | GHGSLTNISR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HDSLKKIDSP | PIRRSTSSGQ | YTGFNDHKPL | DPETIAQDIE | ETMNTALNEL | RELERQSTVK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| HAPDVVLDTL | EQVKNSPTPA | TSTESLSPLH | NVALRGSEPQ | IRRSTSSSSE | TMSTFKPMVA |
| 1030 | 1040 | 1050 | 1060 | ||
| PRMGVQLKPP | ALRPKPAVLP | KTNPTMGPAA | PSQGPTDKSC | TM |