Q812A2
Gene name |
Srgap3 (Arhgap14, Kiaa0411, Srgap2) |
Protein name |
SLIT-ROBO Rho GTPase-activating protein 3 |
Names |
srGAP3, Rho GTPase-activating protein 14, WAVE-associated Rac GTPase-activating protein, WRP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:259302 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q812A2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q812A2-F1 | Predicted | AlphaFoldDB |
No variants for Q812A2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q812A2 | |||||
No associated diseases with Q812A2
No regional properties for Q812A2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q812A2 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5T0N5 | FNBP1L | Formin-binding protein 1-like | Homo sapiens (Human) | PR |
| Q7Z6B7 | SRGAP1 | SLIT-ROBO Rho GTPase-activating protein 1 | Homo sapiens (Human) | PR |
| O94868 | FCHSD2 | F-BAR and double SH3 domains protein 2 | Homo sapiens (Human) | PR |
| Q96RU3 | FNBP1 | Formin-binding protein 1 | Homo sapiens (Human) | PR |
| O75044 | SRGAP2 | SLIT-ROBO Rho GTPase-activating protein 2 | Homo sapiens (Human) | PR |
| Q8CJ53 | Trip10 | Cdc42-interacting protein 4 | Mus musculus (Mouse) | PR |
| Q3USJ8 | Fchsd2 | F-BAR and double SH3 domains protein 2 | Mus musculus (Mouse) | PR |
| Q6PFY1 | Fchsd1 | F-BAR and double SH3 domains protein 1 | Mus musculus (Mouse) | PR |
| Q80TY0 | Fnbp1 | Formin-binding protein 1 | Mus musculus (Mouse) | PR |
| Q8K012 | Fnbp1l | Formin-binding protein 1-like | Mus musculus (Mouse) | PR |
| Q91Z69 | Srgap1 | SLIT-ROBO Rho GTPase-activating protein 1 | Mus musculus (Mouse) | PR |
| Q91Z67 | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2 | Mus musculus (Mouse) | PR |
| D4A208 | Srgap2 | SLIT-ROBO Rho GTPase-activating protein 2 | Rattus norvegicus (Rat) | PR |
| Q8R511 | Fnbp1 | Formin-binding protein 1 | Rattus norvegicus (Rat) | PR |
| Q2HWF0 | Fnbp1l | Formin-binding protein 1-like | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSQTKFKKD | KEIIAEYEAQ | IKEIRTQLVE | QFKCLEQQSE | SRLQLLQDLQ | EFFRRKAEIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEYSRSLEKL | AERFSSKIRS | SREHQFKKDQ | YLLSPVNCWY | LVLHQTRRES | RDHATLNDIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MNNVIVRLSQ | ISEDVIRLFK | KSKEIGLQMH | EELLKVTNEL | YTVMKTYHMY | HAESISAESK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKEAEKQEEK | QFNKSGELSM | NLLRHEDRPQ | RRSSVKKIEK | MKEKRQAKYS | ENKLKCTKAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NDYLLNLAAT | NAAISKYYIH | DVSDLIDCCD | LGFHASLART | FRTYLSAEYN | LETSRHEGLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIENAVDNLD | SRSDKHTVMD | MCSQVFCPPL | KFEFQPHMGD | EVCQVSAQQP | VQTELLMRYH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLQSRLATLK | IENEEVRKTL | DATMQTLQDM | LTVEDFDVSD | AFQHSRSTES | IKSAASETYM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SKINIAKRRA | NQQETEMFYF | TKFKEYVNGS | NLITKLQAKH | DLLKQTLGEG | ERAECGTTRP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PCLPPKPQKM | RRPRPLSVYS | HKLFNGSMEA | FIKDSGQAIP | LVAESCIRFI | NLYGLQQQGI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FRVPGSQVEV | NDIKNSFERG | EDPLVDDQNE | RDINSVAGVL | KLYFRGLENP | LFPKERFQDL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ISTIKLENPA | DRVHPIQQIL | ITLPRVVIVV | MRYLFAFLNH | LSQYSDENMM | DPYNLAICFG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PTLMHIPDGQ | DPVSCQAHVN | EVIKTIIIHH | EAIFPSPREL | EGPVYEKCMA | GGEEYCDSPH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SEPGTIDEVD | HDNGTEPHTS | DEEVEQIEAI | AKFDYVGRSP | RELSFKKGAS | LLLYHRASED |
| 790 | 800 | 810 | 820 | 830 | 840 |
| WWEGRHNGVD | GLIPHQYIVV | QDMDDAFSDS | LSQKADSEAS | SGPLLDDKAS | SKNDLQSPTE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HISDYGFGGV | MGRVRLRSDG | AAIPRRRSGG | DTHSPPRGLG | PSIDTPPRAA | ACPSSPHKIP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LSRGRIESPE | KRRMATFGSA | GSINYPDKKA | LTEGLSMRST | CGSTRHSSLG | DHKSLEAEAL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AEDIEKTMST | ALHELRELER | QNTVKQAPDV | VLDTLEPLKN | PPGPISSEPA | SPLHTIVIRD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| PDAAMRRSSS | SSTEMMTTFK | PALSARLAGA | QLRPPPMRPV | RPVVQHRSSS | SSSSGVGSPA |
| 1090 | |||||
| VTPTEKMFPN | SSSDKSGTM |