Q91XU8
Gene name |
Cds2 |
Protein name |
Phosphatidate cytidylyltransferase 2 |
Names |
CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:114101 |
EC number |
2.7.7.41: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91XU8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91XU8-F1 | Predicted | AlphaFoldDB |
No variants for Q91XU8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q91XU8 | |||||
No associated diseases with Q91XU8
No regional properties for Q91XU8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q91XU8 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.41 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| lipid droplet formation | A process that results in the assembly, arrangement of constituent parts of a lipid droplet. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38221 | CDS1 | Phosphatidate cytidylyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A0JNC1 | CDS2 | Phosphatidate cytidylyltransferase 2 | Bos taurus (Bovine) | PR |
| P56079 | Cds | Phosphatidate cytidylyltransferase, photoreceptor-specific | Drosophila melanogaster (Fruit fly) | PR |
| Q92903 | CDS1 | Phosphatidate cytidylyltransferase 1 | Homo sapiens (Human) | PR |
| O95674 | CDS2 | Phosphatidate cytidylyltransferase 2 | Homo sapiens (Human) | PR |
| P98191 | Cds1 | Phosphatidate cytidylyltransferase 1 | Mus musculus (Mouse) | PR |
| Q99L43 | Cds2 | Phosphatidate cytidylyltransferase 2 | Mus musculus (Mouse) | PR |
| O35052 | Cds1 | Phosphatidate cytidylyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q1PE48 | CDS3 | Phosphatidate cytidylyltransferase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTELRQRAVR | EDAPPEDKES | ESEAKLDGET | ASDSESRAET | APPPTSIDDT | PEVLNRALSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSSRWKNWWV | RGILTMAMIA | FFFIIIYLGP | MVLMMIVMCV | QIKCFHEIIT | IGYNVYHSYD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPWFRTLSWY | FLLCVNYFFY | GETVTDYFFT | LVQREEPLRI | LSKYHRFISF | TLYLTGFCMF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLSLVKKHYR | LQFYMFGWTH | VTLLIVVTQS | HLVIHNLFEG | MIWFIVPISC | VICNDIMAYM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGFFFGRTPL | IKLSPKKTWE | GFIGGFFATV | VFGLLLSYVM | SGYRCFVCPV | EYNNDTNSFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDCEPSDLFR | LQEYNIPGVI | QSLVGWKTMR | MYPFQIHSAL | STFASLIGPF | GGFFASGFKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFKIKDFANT | IPGHGGIMDR | FDCQYLMATF | VNVYIASFIR | GPNPSKLIQQ | FLTLRPDQQL |
| 430 | 440 | ||||
| HIFNTLKSHL | TDKGILMSAL | EEE |