Q1PE48
Gene name |
CDS3 |
Protein name |
Phosphatidate cytidylyltransferase 3 |
Names |
CDP-DAG synthase 3, CDP-DG synthase 3, CDP-diacylglycerol synthase 3, CDS3, CDP-diglyceride pyrophosphorylase 3, CDP-diglyceride synthase 3, CTP:phosphatidate cytidylyltransferase 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G26770 |
EC number |
2.7.7.41: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1PE48
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1PE48-F1 | Predicted | AlphaFoldDB |
21 variants for Q1PE48
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12248217 | 8 | S>N | No | 1000Genomes | |
| ENSVATH12248219 | 20 | T>N | No | 1000Genomes | |
| ENSVATH02928066 | 20 | T>S | No | 1000Genomes | |
| ENSVATH12248221 | 24 | T>N | No | 1000Genomes | |
| ENSVATH12248222 | 32 | T>S | No | 1000Genomes | |
| ENSVATH06781555 | 39 | H>Y | No | 1000Genomes | |
| tmp_4_13482709_C_G | 44 | P>A | No | 1000Genomes | |
| ENSVATH14300010 | 53 | T>I | No | 1000Genomes | |
| tmp_4_13482739_C_T | 54 | P>S | No | 1000Genomes | |
| tmp_4_13482785_A_G | 69 | E>G | No | 1000Genomes | |
| tmp_4_13483100_C_T | 150 | P>L | No | 1000Genomes | |
| ENSVATH06781559 | 184 | R>T | No | 1000Genomes | |
| tmp_4_13483370_C_A | 215 | T>K | No | 1000Genomes | |
| ENSVATH12248265 | 237 | V>I | No | 1000Genomes | |
| ENSVATH06781568 | 328 | G>S | No | 1000Genomes | |
| tmp_4_13483975_C_T | 336 | P>L | No | 1000Genomes | |
| tmp_4_13484187_G_A | 377 | M>I | No | 1000Genomes | |
| tmp_4_13484191_C_A | 379 | P>T | No | 1000Genomes | |
| ENSVATH06781574 | 448 | G>R | No | 1000Genomes | |
| tmp_4_13484648_A_T | 456 | Y>F | No | 1000Genomes | |
| ENSVATH00540021 | 457 | E>G | No | 1000Genomes |
No associated diseases with Q1PE48
No regional properties for Q1PE48
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q1PE48 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.41 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38221 | CDS1 | Phosphatidate cytidylyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A0JNC1 | CDS2 | Phosphatidate cytidylyltransferase 2 | Bos taurus (Bovine) | PR |
| P56079 | Cds | Phosphatidate cytidylyltransferase, photoreceptor-specific | Drosophila melanogaster (Fruit fly) | PR |
| Q92903 | CDS1 | Phosphatidate cytidylyltransferase 1 | Homo sapiens (Human) | PR |
| O95674 | CDS2 | Phosphatidate cytidylyltransferase 2 | Homo sapiens (Human) | PR |
| P98191 | Cds1 | Phosphatidate cytidylyltransferase 1 | Mus musculus (Mouse) | PR |
| Q99L43 | Cds2 | Phosphatidate cytidylyltransferase 2 | Mus musculus (Mouse) | PR |
| O35052 | Cds1 | Phosphatidate cytidylyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q91XU8 | Cds2 | Phosphatidate cytidylyltransferase 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMEKDLSPN | SPRIRKLRDT | SYPTTPTSRM | NTNNQRDNHY | PNIPNSPRDY | NYTPSSPTAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IRHRRRSSEN | LAEVNRSNVS | RVSNLLLGDK | NKYRSMWIRT | CSSLWMLGGV | VFIIYMGHLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IWAMVVVIQI | FMAKELFFLR | RRAHEERRLP | GFWLLNWHFF | FTAMLFVYGR | IIQQQLVNTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSDRFIYKLV | SGLIKYQMVI | CYFLYIAGLI | WFILTLKNKM | YKYQFGQYAW | THMILIVVFT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QSSFTVANIF | EGIFWFLLPA | ALIAMNDVAA | YFFGFYFGKT | PLIKLSPKKT | WEGFIGASVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TIISAFIFAN | VLGQFQWLTC | PRKDLSTGWL | HCDPGPLFRP | EYYPFPSWIT | PFSPWKGIST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPVQWHAFSL | GLFASIMAPF | GGFFASGFKR | AFKIKDFGDS | IPGHGGFTDR | MDCQMVMAVF |
| 430 | 440 | 450 | 460 | 470 | |
| AYIYIQSFIV | NRDYSVEMIL | DQISRSLGHE | EQKMLYEKLG | DILQHKLQGR | F |