P38221
Gene name |
CDS1 (CDG1, YBR029C, YBR0313) |
Protein name |
Phosphatidate cytidylyltransferase |
Names |
CDP-diacylglycerol synthase, CDP-DAG synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CDP-DG synthase, CTP:phosphatidate cytidylyltransferase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBR029C |
EC number |
2.7.7.41: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38221
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38221-F1 | Predicted | AlphaFoldDB |
2 variants for P38221
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-297610 | 45 | P>S | No | SGRP | |
| s02-297606 | 46 | V>A | No | SGRP |
No associated diseases with P38221
No regional properties for P38221
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38221 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.41 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi to plasma membrane transport vesicle | A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidate cytidylyltransferase activity | Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| CDP-diacylglycerol biosynthetic process | The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. |
| phosphatidylinositol metabolic process | The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidylserine metabolic process | The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNC1 | CDS2 | Phosphatidate cytidylyltransferase 2 | Bos taurus (Bovine) | PR |
| P56079 | Cds | Phosphatidate cytidylyltransferase, photoreceptor-specific | Drosophila melanogaster (Fruit fly) | PR |
| Q92903 | CDS1 | Phosphatidate cytidylyltransferase 1 | Homo sapiens (Human) | PR |
| O95674 | CDS2 | Phosphatidate cytidylyltransferase 2 | Homo sapiens (Human) | PR |
| P98191 | Cds1 | Phosphatidate cytidylyltransferase 1 | Mus musculus (Mouse) | PR |
| Q99L43 | Cds2 | Phosphatidate cytidylyltransferase 2 | Mus musculus (Mouse) | PR |
| O35052 | Cds1 | Phosphatidate cytidylyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q91XU8 | Cds2 | Phosphatidate cytidylyltransferase 2 | Rattus norvegicus (Rat) | PR |
| Q1PE48 | CDS3 | Phosphatidate cytidylyltransferase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDNPEMKPH | GTSKEIVESV | TDATSKAIDK | LQEELHKDAS | ESVTPVTKES | TAATKESRKY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NFFIRTVWTF | VMISGFFITL | ASGHAWCIVL | ILGCQIATFK | ECIAVTSASG | REKNLPLTKT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNWYLLFTTI | YYLDGKSLFK | FFQATFYEYP | VLNFIVTNHK | FICYCLYLMG | FVLFVCSLRK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFLKFQFGSL | CVTHMVLLLV | VFQAHLIIKN | VLNGLFWFLL | PCGLVIVNDI | FAYLCGITFG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KTKLIEISPK | KTLEGFLGAW | FFTALASIIL | TRILSPYTYL | TCPVEDLHTN | FFSNLTCELN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PVFLPQVYRL | PPIFFDKVQI | NSITVKPIYF | HALNLATFAS | LFAPFGGFFA | SGLKRTFKVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DFGHSIPGHG | GITDRVDCQF | IMGSFANLYY | ETFISEHRIT | VDTVLSTILM | NLNDKQIIEL |
| 430 | 440 | 450 | |||
| IDILIRFLSK | KGIISAKNFE | KLADIFNVTK | KSLTNHS |