P56079

PR
Gene name
Cds
Protein name
Phosphatidate cytidylyltransferase, photoreceptor-specific
Names
CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7962
EC number
2.7.7.41: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P56079

Entry ID Method Resolution Chain Position Source
AF-P56079-F1 Predicted AlphaFoldDB

No variants for P56079

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P56079

No associated diseases with P56079

2 regional properties for P56079

Type Name Position InterPro Accession
domain Fatty acyl-coenzyme A reductase, NAD-binding domain 130 - 400 IPR013120
domain Fatty acyl-CoA reductase, C-terminal 472 - 562 IPR033640

Functions

Description
EC Number 2.7.7.41 Nucleotidyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
phosphatidate cytidylyltransferase activity Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

11 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
negative regulation of triglyceride biosynthetic process Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
phototransduction The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
positive regulation of phosphatidylinositol biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
regulation of lipid storage Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
rhodopsin mediated signaling pathway A G protein-coupled receptor signaling pathway initiated by the excitation of rhodopsin by a photon, and ending with the regulation of a downstream cellular process.
sperm individualization The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.
terminal branching, open tracheal system Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
thermotaxis The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38221 CDS1 Phosphatidate cytidylyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A0JNC1 CDS2 Phosphatidate cytidylyltransferase 2 Bos taurus (Bovine) PR
Q92903 CDS1 Phosphatidate cytidylyltransferase 1 Homo sapiens (Human) PR
O95674 CDS2 Phosphatidate cytidylyltransferase 2 Homo sapiens (Human) PR
P98191 Cds1 Phosphatidate cytidylyltransferase 1 Mus musculus (Mouse) PR
Q99L43 Cds2 Phosphatidate cytidylyltransferase 2 Mus musculus (Mouse) PR
O35052 Cds1 Phosphatidate cytidylyltransferase 1 Rattus norvegicus (Rat) PR
Q91XU8 Cds2 Phosphatidate cytidylyltransferase 2 Rattus norvegicus (Rat) PR
Q1PE48 CDS3 Phosphatidate cytidylyltransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAEVRRRKGE DEPLEDTAIS GSDAANKRNS AADSSDHVDS EEEKIPEEKF VDELAKNLPQ
70 80 90 100 110 120
GTDKTPEILD SALKDLPDRW KNWVIRGIFT WIMICGFALI IYGGPLALMI TTLLVQVKCF
130 140 150 160 170 180
QEIISIGYQV YRIHGLPWFR SLSWYFLLTS NYFFYGENLV DYFGVVINRV EYLKFLVTYH
190 200 210 220 230 240
RFLSFALYII GFVWFVLSLV KKYYIKQFSL FAWTHVSLLI VVTQSYLIIQ NIFEGLIWFI
250 260 270 280 290 300
VPVSMIVCND VMAYVFGFFF GRTPLIKLSP KKTWEGFIGG GFATVLFGIL FSYVLCNYQY
310 320 330 340 350 360
FICPIQYSEE QGRMTMSCVP SYLFTPQEYS LKLFGIGKTL NLYPFIWHSI SLSLFSSIIG
370 380 390 400 410 420
PFGGFFASGF KRAFKIKDFG DMIPGHGGIM DRFDCQFLMA TFVNVYISSF IRTPSPAKLL
430 440
TQIYNLKPDQ QYQIYQSLKD NLGDMLT