P98191

PR
Gene name
Cds1
Protein name
Phosphatidate cytidylyltransferase 1
Names
CDP-DAG synthase 1, CDP-DG synthase 1, CDP-diacylglycerol synthase 1, CDS 1, CDP-diglyceride pyrophosphorylase 1, CDP-diglyceride synthase 1, CTP:phosphatidate cytidylyltransferase 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74596
EC number
2.7.7.41: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P98191

Entry ID Method Resolution Chain Position Source
AF-P98191-F1 Predicted AlphaFoldDB

23 variants for P98191

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3395904964 16 A>V No EVA
rs3388761414 67 R>K No EVA
rs3388773275 92 L>F No EVA
rs3388744092 98 S>P No EVA
rs3388755516 137 Y>F No EVA
rs3388777189 137 Y>H No EVA
rs3395782161 144 T>W No EVA
rs3388755575 148 Y>* No EVA
rs3388771266 200 L>P No EVA
rs3388779841 217 T>K No EVA
rs3388773582 236 F>Y No EVA
rs3388744082 259 F>I No EVA
rs3388770194 265 R>I No EVA
rs3388774175 270 K>M No EVA
rs3388755541 287 T>A No EVA
rs3388770217 288 V>L No EVA
rs3388773801 302 Q>R No EVA
rs3388761455 306 C>Y No EVA
rs3395972909 366 I>T No EVA
rs3395932048 367 G>S No EVA
rs3388766676 407 A>V No EVA
rs3388761441 437 Q>H No EVA
rs3388777177 441 I>F No EVA

No associated diseases with P98191

2 regional properties for P98191

Type Name Position InterPro Accession
domain Mediator complex, subunit Med25, PTOV domain 42 - 188 IPR021394-1
domain Mediator complex, subunit Med25, PTOV domain 214 - 358 IPR021394-2

Functions

Description
EC Number 2.7.7.41 Nucleotidyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
phosphatidate cytidylyltransferase activity Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

4 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
lipid droplet formation A process that results in the assembly, arrangement of constituent parts of a lipid droplet.
phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38221 CDS1 Phosphatidate cytidylyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A0JNC1 CDS2 Phosphatidate cytidylyltransferase 2 Bos taurus (Bovine) PR
P56079 Cds Phosphatidate cytidylyltransferase, photoreceptor-specific Drosophila melanogaster (Fruit fly) PR
O95674 CDS2 Phosphatidate cytidylyltransferase 2 Homo sapiens (Human) PR
Q92903 CDS1 Phosphatidate cytidylyltransferase 1 Homo sapiens (Human) PR
Q99L43 Cds2 Phosphatidate cytidylyltransferase 2 Mus musculus (Mouse) PR
Q91XU8 Cds2 Phosphatidate cytidylyltransferase 2 Rattus norvegicus (Rat) PR
O35052 Cds1 Phosphatidate cytidylyltransferase 1 Rattus norvegicus (Rat) PR
Q1PE48 CDS3 Phosphatidate cytidylyltransferase 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLELRHRGGC PGPGGAGAPP PREGEAAGGD HETESTSDKE TDIDDRYGDL DARGDSDVPE
70 80 90 100 110 120
VPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMISLF FLIIYMGSFM LMLLVLGIQV
130 140 150 160 170 180
KCFHEIITIG YRVYHSYDLP WFRTLSWYFL LCVNYFFYGE TVADYFATFV QREEQLQFLI
190 200 210 220 230 240
RYHRFISFAL YLAGFCMFVL SLVKKHYRLQ FYMFAWTHVT LLITVTQSHL VIQNLFEGMI
250 260 270 280 290 300
WFLVPISSVI CNDITAYLFG FFFGRTPLIK LSPKKTWEGF IGGFFSTVIF GFIAAYVLSK
310 320 330 340 350 360
YQYFVCPVEY RSDVNSFVTE CEPSELFQLQ NYSLPPFLQA VLSRETVSLY PFQIHSIALS
370 380 390 400 410 420
TFASLIGPFG GFFASGFKRA FKIKDFANTI PGHGGIMDRF DCQYLMATFV HVYITSFIRG
430 440 450 460
PNPSKVLQQL LVLQPEQQLN IYRTLKIHLT EKGILQPTLK V